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外文资料--Multi-objective Optimization Research for Effective.PDF

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外文资料--Multi-objective Optimization Research for Effective.PDF

MULTIOBJECTIVEOPTIMIZATIONRESEARCHFOREFFECTIVECONSTITUENTSOFQILIQIANGXINCAPSULEOFCHINESEFORMULAHONGTAOWANG,JIMINGJIA,SIWENTANG,DENGFENGXU,YAJIEZHENG,HUIXINZHANG,YILINGWU#PHARMACOLOGYLABORATORYTHEINTEGRATIONOFTRADITIONALANDWESTERNMEDICALRESEARCHACADEMYOFHEBEIPROVINCESHIJIAZHUANG,CHINA#CORRESPONDINGAUTHORRENQUANLIUBEIJINGUNIVERSITYOFCHINESEMEDICINEBEIJING,CHINAAABSTRACTTHESYSTEMATICEFFECTSFROMMANYACTIVEINGREDIENTSINCHINESEMEDICINEPREPARATIONARETHEHIGHLIGHTTOEVALUATECURATIVEEFFECTSANDOPTIMIZETHEFORMULATHECOMMONDESIGNCOULDGETTHEIDEALOPTIMIZATIONQILIQIANGXINQLQXCAPSULEEXERTSITSEFFECTSONCHRONICHEARTFAILURETHROUGHCARDIACANDDIURESISANDDILATINGVESSELINOURPREVIOUSRESEARCH12SAMPLESWEREOBTAINEDBYWATERANDALCOHOLEXTRACTINGANDMACROPOROUSRESINPURIFYINGTHEACTIVESITESWERESCREENEDWITHTHEEXPERIMENTSOFISOLATEDFROGHEARTANDAORTAPERFUSIONANDDIURESISTHERESULTSSUGGESTEDTHATW3,W4,E2,E3,E4WEREMAJORACTIVESITESHERETHELARSWASADOPTEDTODESIGNTHEEXPERIMENTOFHEARTFAILUREINRATSANDOPTIMIZEDIFFERENTINDEXINTHERESULTSTHESTUDYWASTOEXPLOREANOVELMETHODTOOPTIMIZECHINESEMEDICINEFORMULAKEYWORDSEFFECTIVECONSTITUENTS;MULTIOBJECTIVEOPTIMIZATION;DATAMINING;CHINESEMEDICINEINTRODUCTIONFORMULAINTRADITIONALCHINESEMEDICINEHAVEHELPEDCHINESEANCIENTSTOFIGHTWITHDISEASESDURINGPASTTHOUSANDSYEARSANDVALIDATEDBYMOREANDMORECLINICALEXPERIENCEQILIQIANGXINCAPSULEQLQXISANEFFECTIVEFORMULATOTREATCHRONICHEARTFAILURECHFINCLINICS1MANYCLINICALEVIDENCESHAVEDEMONSTRATEDTHEEFFICIENCYOFITHOWEVER,THEMATERIALBASISOFTHEFORMULAFORTREATINGTHEDISEASEREMAINSUNCLEARRELATIONSHIPBETWEENCHEMICALINGREDIENTSOFQLQXANDBIOLOGICALPARAMETERSTHATSIGNIFICANTLYASSOCIATEDWITHTHECHFISABETTERAVENUETOUNCOVERTHEMATERIALBASISOFTHEFORMULABASEDONTHERELATIONSHIPBUILT,THEOPTIMALPROPORTIONOFHERBALSTHATCONSTITUTETHEFORMULACANBECALCULATEDFROMTHEPROPERPROPORTIONOFHERBALSMEANSTHATEACHHERBALHASITSDIFFERENTROLETOPLAYINCONSTITUTINGAFORMULA,WHICHISANIMPORTANTTHEORYANDVIEWPOINTINTCMTHEFIVEHERBALSINTHEQLQXCANBESEENASA“TEAM’TOFIGHTWITHCHFSINCETHEREARESEVERALBIOLOGICALPARAMETERSTOEVALUATECHF,THEREFORE,THEOPTIMALPROPORTIONOFHERBALSSHOULDBECOMPUTEDBYMULTIOBJECTIVEOPTIMIZATIONALGORITHMINTHISPAPER,WEPRESENTEDANOVELMETHODTOESTABLISHRELATIONSHIPBETWEENCHEMICALINGREDIENTSOFQLQXANDBIOLOGICALPARAMETERSOFCHFANDPREDICTTHEOPTIMALPROPORTIONOFHERBALSWEFIRSTLYCARRIEDOUTAUNIFORMDESIGNTOCOMBINETHEDIFFERENTCONCENTRATIONOFFIVEINGREDIENTSTHENANIMALSMODELWITHCHFWEREBUILTTOEVALUATETHECOMBINATIONTHENTHELEASTANGLEALGORITHMWASUSEDTOESTABLISHRELATIONSHIPBETWEENFIVEHERBALSANDBIOLOGICALPARAMETERSFINALLY,MULTIOBJECTIVEOPTIMIZATIONALGORITHMWEREPRESENTEDTOCALCULATETHEOPTIMALPROPORTIONITMATERIAL11ANIMAL280SDRATS,FEMALEANDMALE,WEIGHT140160G,BEIJINGVITALRIVEREXPERIMENTALANIMALTECHNIQUECO12TESTEDARTICLETESTEDARTICLEW3、W4、E2、E3、E4WASSUPPLIEDBYHEBEIYILINGMEDICINALINSTITUTEEVERYSAMPLEWASPREPAREDFOR11DIFFERENTCONCENTRATIONRESPECTIVELYAND11NEWSAMPLESWASOBTAINEDBYEVERY5SAMPLECOMBINATIONFOLLOWINGTABLE11TABLE11THEEXPERIMENTALDESIGNOF11LEVELSWITH5INGREDIENTSNOW3W4E3E4E2112357224610333694104481965510432661789773102588527199751810109864111111111111TABLE12COMPOSITIONWITHACTIVESITES(UNITMG/ML)NOW3CONW4CONE3CONE4CONE2CONQLQX10034804346081962306227200QLQX20069512072238957037806531QLQX30139033533696641844979299QLQX40278093146040165630319040QLQX505560258740117081475904571QLQX61112002608341354504255509QLQX72224007243995201180813328QLQX844480201200573736034032009781424447138/10/25002010IEEEQLQX98896055888167260944638857QLQX1017792155244487652882709329QLQX113558443123314217879731132813REAGENTTRIPHENYLTETRAZOLIUMCHLORIDEPURCHASEDFROMSINOPHARMCOLTDBATCHNUMBERF20040531。14INSTRUMENTSBL420EBIOLOGICALSIGNALACQUISITIONSYSTEM,CHENDOUTAIMENGSCIENCEANDTECHNOLOGYCOLTD2METHODSANDRESULTS21SURGICALPREPARATIONSDRATSWASANESTHETIZEDWITHCHLORALHYDRATE350MG/KGTHELEFTTHORACOTOMYWASPERFORMEDINTHEFOURTHINTERCOSTALSSPACEANDTHEPERICARDIUMWASOPENEDTOEXPOSETHEHEARTA0SILKSUTUREWASPASSEDAROUNDTHELEFTANTERIORDESCENDINGCORONARYARTERYAPPROXIMATELY12MMFROMITSORIGINANDLIGATEDTHEARTERYTOOCCLUDETHEBLOODFLOWTHESHAMGROUPUNDERWENTTHESAMEPROCEDUREWITHOUTLIGATINGTHECORONARYARTERY22MEASUREMENTOFCARDIACFUNCTIONTHELEFTVENTRICULARINTUBATIONWASADOPTEDTODETERMINESYSTOLICBLOODPRESSURESBP,DIASTOLICBLOODPRESSUREDBP,MEANARTERIALPRESSURESMAP,LEFTVENTRICULARPRESSURE(LVP,LEFTVENTRICULARENDDIASTOLICPRESSURE(LVEDP),MAXIMALRISINGANDFALLINGRATEOFLEFTVENTRICULARPRESSURE(LVDP/DTMAXANDHEARTRATEHR23INFARCTSIZEDETERMINATIONPETTYMA,DOWJ,GRISARJM,JONGWDEEFFECTOFACARDIASELECTIVEALFATOCOPHEROLANALOGUEONREPERFUSIONINJURYINRATSINDUCEDBYMYOCARDIALISCHEMIAEURJPHARMACOL1991;192383388HAYASHIN,FUJIMURAY,YAMAMOTOS,KOMETANIM,NAKAOKPHARMACOLOGICALPROFILEOFVALSARTAN,ANONPEPTIDEANGIOTENSINIITYPERECEPTORANTAGONISTARZNEIMITTELFORCHUNG1997;47625629THEFRESHHEARTWASEXCISED,RINSED,FROZENFORABOUT1HOUR,ANDSLICEDINTO5SECTIONSFROMAPEXTOBASETHESLICESWEREINCUBATEDIN1TRIPHENYLTETRAZOLIUMCHLORIDEPHOSPHATEBUFFERSOLUTIONAT37℃FOR15MINTHEINFARCTIONAREAWASSEPARATEDFROMWHOLEHEARTANDWEIGHTEDTHEINFARTIONSIZEWASCACULATEDWITHTHEFORMULATHEINFARTIONSIZEWEIGHTOFINFARCTIONSIZE/WEIGHTOFWHOLEHEART23DATAMININGMETHODSLARSISAKINDOFREGRESSIONALGORITHMTHEAIMOFITISTOSOLVETHEFOLLOWINGEQUATIONS220111MINPNIIJIJPJJYXSTCΒΒΒΒ−−≤∑∑∑INGENERAL,THEREGRESSIONALGORITHMISPERFORMEDBYFOURSTEPSSTARTWITHALLCOEFFICIENTSJΒEQUALTOZEROFINDTHEPREDICTORJXMOSTCORRELATEDWITHYINCREASETHECOEFFICIENTJΒINTHEDIRECTIONOFTHESIGNOFITSCORRELATIONWITHYTAKERESIDUALSRYY’ALONGTHEWAYSTOPWHENSOMEOTHERPREDICTORKXHASASMUCHCORRELATIONWITHRASJXHASINCREASEJΒ,KΒINTHEIRJOINTLEASTSQUARESDIRECTION,UNTILSOMEOTHERPREDICTORMXHASASMUCHCORRELATIONWITHTHERESIDUALRCONTINUEUNTILALLPREDICTORSAREINTHEMODELRESULTSBYOPTIMIZATION,THEBESTPROPORTIONOFFIVEINGREDIENTSISW3W4E3E4E252989FIGURE12,TABLE24FIGURE1THEREGRESSIONCOEFFICIENTSOFCHEMICALINGREDIENTSFORTABLE23BYDATAMININGMETHODSTABLE2THEBLOODPRESSUREANDHROFRATSSUFFEREDFROMCORONARYARTERYLIGATIONGROUPSBP(MMHG)DBP(MMHG)MAP(MMHG)HR(BEAT/MIN)SHAM992521096293197375041909421415327MODEL928327354477170360791871349035363QLQX18104106141675765479738377452263QLQX2950719605346183467321617387713214QLQX3989620414915176765761722380883735QLQX48053230247551758585418353337611908QLQX5111387487041117084071023427692681QLQX6966724325068204366012079367735155QLQX71037112845547132471551211375227291QLQX81066915985774188074051664365145328QLQX91011314485434154669941326378264011QLQX10841619354581100258601231380303149QLQX11886923114040153556501658340636213TABLE3THELVP、LVEDP、LVDP/DTMAXOFRATSSUFFEREDFROMCORONARYARTERYLIGATIONGROUPLVP(MMHG)LVEDP(MMHG)LVDP/DTMAX(MMHG/MS)LVDP/DTMAX(MMHG/MS)SHAM104622780399323343102278094MODEL111702622811343319068277063QLQX18568997504198282058214024QLQX2108382378618326330086277060QLQX3108022397599375334097255083QLQX486962899388161273094211073QLQX512391557586399414022332016QLQX6104872703595366335082270086QLQX7110451469724163352037276035QLQX8118041936816409372069298072QLQX9114191838769348355058307063QLQX1096432478650386298089249076QLQX1197622662620464295093250080FIGURE2THEREGRESSIONCOEFFICIENTSOFCHEMICALINGREDIENTSFORTABLE4BYDATAMININGMETHODSTABLE4INFARCTIONSIZEOFRATSSUFFEREDFROMCORONARYARTERYLIGATIONGROUPINFARCTIONSIZE()SHAM155213VEHICLE820416QLQX1972530QLQX2705563QLQX3417224QLQX4655492QLQX5704378QLQX6620364QLQX7749265QLQX8605488QLQX9906368QLQX101011422QLQX11851571CONCLUSIONW3、W4、E2、E3ANDE4ISEFFECTIVEANDACTIVEINGREDIENTSOFQLQWITHTHEIRACTIVITIESONHEARTSTRENGTH,BLOODVESSELDISTENTIONBYUSINGUNIFORMDESIGNANDDATAMININGMETHODS,THEASSOCIATIONSBETWEENCHEMICALINGREDIENTSANDBIOACTIVITIESWEREESTABLISHEDANDTHECORRESPONDINGBIOACTIVITIESWEREOPTIMIZEDTHESTRATEGYPRESENTEDINTHEPAPERPAVESABASISFORREDEVELOPINGTCMHERBALSANDHERBALCOMBINATIONSFORMULAACKNOWLEDGEMENTTHEWORKWASSUPPORTEDBYTHEPROJECTFUNDOFNATIONALSCIENTIFICANDTECHNICALSUPPORTPLANDURINGTHE11THFIVEYEARPLAN(NO2006BAI08B0409)ANDTHENATIONALBASICRESEARCHPROGRAMOFCHINA973PROGRAMUNDERGRANTNO2005CB523301REFERENCE1WUYILING,COLLATERALDISEASETHEORYINPRACTICE,MBEIJINGCHINASCIENCEANDTECHNOLOGYPRESS,20042832842BRADLEYEFRON,TREVORHASTIE,IAINJOHNSTONE,ETCLEASTANGLEREGRESSION,THEANNALSOFSTATISTICS,2004,VOL32,NO2,407–451

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