383例阴道念珠菌感染菌群鉴定及药敏分析.doc

383例阴道念珠菌感染菌群鉴定及药敏分析【关键词】念珠菌性阴道炎；,菌种鉴定；,药物敏感试验【摘要】目的分析念珠菌性阴道炎的临床分离菌特点及抗念珠菌药物的耐药情况。方法按NCCLS推荐的M27A方案（肉汤微量稀释法）检测氟康唑等6种抗真菌药对6种共52株深部致病念珠菌临床分离株在体外的抗真菌活性。结果383例标本中以白色念珠菌居多9609，其次为光滑念珠菌261，较少的有热带念珠菌104与克柔念珠菌026。药物敏感试验显示制霉菌素、两性霉素Ｂ的敏感性均在90以上，耐药率以伊曲康唑为最高358，其次为氟康唑175。结论念珠菌性阴道炎的临床分离菌除了白色念珠菌外，尚有光滑念珠菌、热带念珠菌及克柔念珠菌等菌种，制霉菌素与两性霉素Ｂ对念珠菌的敏感性较好，而伊曲康唑与氟康唑的耐药率比较高，应引起临床医师的重视。【关键词】念珠菌性阴道炎；菌种鉴定；药物敏感试验【ABSTRACT】OBJECTIVETOANALYZETHECLINICSEPARABLECHARACTERISTICSANDCOMPARETHEACTIVITIESOFFLUCONAZOLEWITHOTHER5ANTIFUNGALAGENTSIN383CASESOFCANDIDAVIGINITISMETHODSMICROBIALPOPULATIONWASDETERMINEDBYTHEMETHODGUIDEDTOTHESTANDARDM27ARECOMMENDEDBYTHENATIONALCOMMITTEEFORCLINICALLABORATORYSTANDARDSRESULTSRANKEDFROMTHEHIGHESTTOTOTHELOWESTASCALBICANS9609,CGLABRATA261,CTROPTICAL104,CKRUSEI026CANDISTATINANDAMPHOTERICINBWEREMOSTEFFECTIVEAGAINSTALLTHETESTEDCLINICALCANDIDAISOLATESGT；90THERATESOFDRUGFASTWEREITRACONAZOLE358,FLUCONAZOLE175CONCLUSIONCALBICANS,CGLABRATA,CTROPTICAL,ANDCKRUSEIWEREIDENTIFIEDINALLTHE383CASESOFCANDIDAVIGINITI