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常用中药及复方制剂的肝毒性.pdf

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常用中药及复方制剂的肝毒性.pdf

2007M4nullnullnullnull»28null»2ùnullnullnullnûDSvÐÐJournalofCapitalMedicalUniversitynullnullnullApr.2007Vo.l28nullNo.2null5¡null常用中药及复方制剂的肝毒性王秀娟null许利平null王null敏nûDSvÐÏD0ÐýK1nullÏ0îÁÉýŸ¥5VCÐÈnÉhM»,VCŸÉåaÉÿsÈaÓb¼½6ÚaÉÖvaÛia‰¬¾a¤ŸÉô8»ÄaÉ—ÄaŸɚ°ÉÖ©òÕhØMÄbT0ª,”ÉåVI¥bÈn¥µÉýŸ†Å0µÛ00a›90aÂ,aÛam0aI©Èn¥ÉýŸ¯ZÅ4µ1«™agÛa¯Z™aX™al¸±©bÏ0¥øÏ0ó†¨0VÁÉýŸ¥3Ï0¥0ŸÐÉýŸ9µ1„ÉýŸ¥ðyÐÏ0¥ýŸµ1“,ÐD€¨04„¨0HWÐÑ€8É9µ1,1«a¹©yÍ9„ÉýŸ¥1ðybºµÏD0؂/,O£Í,4ÚDŒ,†Ø¨0,Œ¸Ï0¯ZÅ4„ÉýŸ¥µrnb1oMnullÏ0¯ZÅ4ÉýŸÏmsË|nullR285HepatotoxicityCausedbyCommonlynullusedChineseMedicinalHerbsandCompoundPreparationWangXiujuan,XuLiping,WangMinSchoolofTraditionalChineseMedicine,CapitalMedicalUniversityABSTRACTnullThemanifestationsofhepatotoxicitycausedbyChinesemedicinalherbsaresimilarwithordinaryliverdisease.Manypathologicalalterationsofhepatotoxicitycanbeseen,suchashepatocellulardamage,liverdisfunction,increasedserumtransaminase,hepatomegalia,jaundice,cholestasis,chronichepatitiscomplicatedwithfibrosis,hepaticcirrhosisafulminatinghepaticfailure,livertumor,andetc.Inmostcases,theliverdamageisreversibleafterdiscontinuation.ThecommonlynullseenherbswhichmaycausehepatotoxicityareHuangYaoZiTuberDioscoreaeBulbiferaeaCangErZiFructusXanthiiSibiriciaLeiGongTengRadixTripterygumaKuLianZiFructusMeliaeAzedarach,etc.,andthecompoundpreparationsareZhuangGuGuanJIeWanThePillforAsthritis,KeYinWanThePillforPsoriasis,XiaoChaiHuTangXiaoBupleuriDecoction,andsoon.Inaddition,theimpropercombinationofWesternmedicationandChinesemedicinalherbsmayalsobringabouthepatotoxicity.Exceptthetoxicityofherbsthemselves,theotherfactorsincludethedosage,time,thebodyconstitutionofpatients,sensitivity,seasons,andgeographicregions,etc.Therefore,themedicinalherbsandtheirpreparationsshouldbeusedrationallyundertheguidanceofthetheoryoftraditionalChinesemedicineanddifferentiationofsymptoms,andthemedicalskillshouldbeimproved,whicharetheeffectivemeasuresforavoidinghepatotoxicity.KEYWORDSnullChinesemedicinalherbscompoundpreparationhepatotoxicitynullnullÉT¹0þ}†¥ö12,¸sž0þ¥å,7Ϥ0®òÕÄÐîsîFî,ƒtîs8è0r¥H,9µ3‚Q‹¥VŸ,.ÀÉ/îýŸåbjƒñÙ5iɛƥùî,¿£¨0½†,h„0÷ŸÉhµ¥ilb1null†ÅÏ0„¥ÉåϤ0îÁ¥ÉåÀµsŸ1,5VCÐÈnÉhM»,T0ª,”ÉåVIbÓD¡2,„Éå¥È¨†ÅÏ0µÛ00aÂ,a›90aÛanéam0a0a›ŒaÁ‚ÐaIaÂ73©bÈnÏ0ÉýŸ¥5¡Â/Û00Ȩ¿ÍJGaJFaŸ8»©bÉÏýVCË»hýŸÉ36,ö1VC¹0a|sa²HaUÛ,ÉÿsÈbÊë¼Ö¼½SGOTad¼Ö¼¼½ALT„‰£Í6Úb„É奰¨¹1536g,9¹903500gbhHW¹›0ª6d14ÛbÛ00„Éå¥.™ùhf¥Ð0þ¥4µ1,4v,.™ù,hfb”Ñ€›09»2ù¦®©È¨Ï0¯ZÅ4¥ÉýŸr5001500gªhbhªÉ¡,Ð͇h¥Ï0„¥ÉåM»,iµµ§hè¡bÂ,7,8„Éå¥5VC»ŸhýŸÉ,µCïa,µa0a|saUÛaۙ©¡,ÉÖv,µâe,Ób¼½6Ú,‰¬|üAb5µµ§hè¡,ö1µyÉÿå,H†iµìhb¡,Â,ËÂ,øË÷„Éåb›90Ïý¥.™ùÿ110db5VC¹0a|sa´ea´LÝhehaa_¤aP©hÄdÐÜd¡,­CÉu.eaÉÖvaÛiaALT6ÚÓ†®,iVCa7a/©LÉ¥åbÚÅ4¥½†ŸÙ5,ÍMŸX„‡S0Ö„rÖ5ØMHRA1ÿ,MHRA̸cµÚ‹›0Ö¥grb2003M3,Á1ÏS¥ã0ˇSgÆgr„MHRA¥ÿibã0ËcµÚ¥Ïî0Å4,ÚÚ‹±þÕËîô,¾‹±þcµýŸ¥‚„6ÚJË3þaPAs,íÂÚaaÚcaaÚaNnullÄþaÚcaNnullÄþ,Äв˻7ä†ab‚„6ÚJË3þaPAsöÉ/îøå,Á¦ËÉláÖ¡VOD,³1É›ÉM±iVÁµ§25bÚ26îc¥6ÚJ3þaX©¥Kö1¥±þŸÉýîs,Ïý¡VC¹ÂCíïa0a|sa´naÛiaUa´£©,ÎVÁÉ´ak´ø©b³ýû2¥“¨Ï¤0ýŸùî27Vü,c£³˜ÏÉ¥0þÉøå,ƒtϤ0ia¹ÁaFÃaÛžaÖôÃaô0a‡„0©bµÓD¡27,28,„¥ÉýŸ¥Ï0,µ¹Ÿa¦Ûa›90aþa¹aÊMa¹1aa60arØþaä‰0a⽕ajæ7ä†aaôä¼aàParÒav„0avâä¤cÚ3þaa½xaÊk¤aؘbLi_°Éå¹ö,Œ‚CALP„¼ÿM½nullnullGTüA6Ú¥‰¬¾˜Éb¯ZÅ4„¥Éå1«™¡,QÍÑh¥X™ah™ahËahËa©,ðÈnÏ0¯Z24,29,30Âl¸±a¯Z™a¿„/™avŽ™a„i™a™aΑ™a7½am7aa7ïšahFa¯ZU0Ûaľ™a¾ÐmÉ™aüöZahW™ahFa™anéËahU0a½Ž™a¿„/™avŽ™adÛ³ýË©µ¡b1«™2„Éå¥hqÚ,Ü.™ù¹46.8d,oŸn,ÜM57.1ß,ö1‚Q‹¹Ã‘„avLçâ„Ûi,aŸÖ½ALT„nullnull¼ÿt½GGTüA6Ú,5‰¬¾˜ÉnbdÛ³ý™ËÏ¥¦ÛýŸKÝ.Ï0Ïýг÷M.ØÏSD0S/ñ,1991106110,133137,122127.10¦Z.Ϥ0„ÏýŸÉh¥hØMÄJ.5ɉh½,1997,131619.11Ƀ,¦a3.SD0ÐùáÛ,¦–,çÖ.50è0÷ŸÉå¥54³ÐsJ.ÏSDý0н,1996,16379380.29¬¡œ,°/.116è0÷ŸÉåsJ.0þ›hн,1998,7142145.30Ij–,¦âV,È£,©.77èÏ0‚Q‹áÐsJ.0þ‚Q‹½,2003,5231234.31uÁY,¸cö.Ïî0dÛ³ý™Ë¥‚Q‹SnJ.ªÏ0½,2001,1563.32³B.¯Z™Á0þŸÉ2èJ.ÏSÏD²†½,1994,14539.33fë,ÊZ‚.¯Z™ÁÉÿåBèJ.ϿÑS½,1993,2628.34¦a,Ü,½µ.±þ0¥ÉýŸJ.ÏDÐýÐ,2004,167880.35çrö.¤0l¸±„¥ÉåJ.S“DÐnullhÄdhs¨,1996,1661.36ÝV.kÏ0îÁ0þŸÉåJ.ÏD²†Éh½,2001,116365.37_ê.B™Á0þŸÉ1è¡J.óqDн,1995,1938.38¦qç,¦æ.Ϥ0Ál8Éå18èáJ.„ÏDÐýÐ,1996,2019.39Ûi,uy¿.0BtÏî0¥‚Q‹J.„5DÐ,2002,4337.40u.ê.Ï0‚Q‹yÍÏ0¥øÌ£j,f¹,¦£¼.kÏ0†¨3‚Q‹¥ØJ.L¨ÏD0½,2001,1745.42ÃeÆ,È3.ÉýŸÏ0Ð0Ÿ„µrîs¥1J.öÏDÐýÐ,2001,21819.43Ùr,¦©,I6,©.0÷ŸhÄhM.ØSÐ/Œñ,2001408409.44¦öá,çrö.Ë0þFÖT¨¥ùîÉZJ.©M,1996,33361366.45­.ÏS0¨JìS¥÷I³Ðæ¨J.Ð,1995,38324331.46ƒë,ÅÝ,¦§,,©.ØÄÍâÓh¥N´J.ÏSDý0н,2000,203233.là°ù20070116224

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