西酞普兰与米安舍林治疗老年抑郁症的对照研究.pdf

中国实用医药2010年1月第5卷第2期CHINAPRACMED，JAN2010．VO1．5．NO．2西酞普兰与米安舍林治疗老年抑郁症的对照研究贾金鼎郭平【摘要】目的比较西酞普兰与米安舍林治疗老年抑郁症的疗效及安全性。方法选择符合人组条件的78例抑郁症患者，随机分为两组，分别给予西酞普兰与米安舍林治疗，疗程8周，采用汉密尔顿抑郁量表HAMD及汉密尔顿焦虑量表HAMA在治疗前及治疗的2468周评定药物疗效；用副反应量表TESS评定不良反应。结果西酞普兰组与米安舍林组总体疗效相当，疗后HAMD和HAMA总分均有显著减少，西酞普兰组起效快，不良反应轻，安全性好。结论西酞普兰治疗老年抑郁症安全有效，并且起效快。不良反应轻。【关键词】西酞普兰；米安舍林；老年抑郁症COMPARATIVESTUDYOFCIRALOPRAMANDMIANSERININTHETREATMENTOFDEPRESSIONJIAJINDING，GUOPING．ZHUMADIANCITYSMENTALHOSPITAZ．HENAN463000，CHINA【ABSTRACT】0BJECTIVETOEXPLORECLINICALEFFICACYANDSAFELYOFCITALOPRAMANDMIANSERININTHETREATMENTOFDEPRESSION．METHODSSIXTYEIGHTPATIENTSWITHDEPRESSIONWERETREATEDRANDOMLYWITHCITALOPRAMORMIANSERINFORSIXWEEKS，ANDMEASUREDWITHHAMILTONDEPRESSIVESCALEHAMD，HAMILTONANXIETYSCALEHAMAANDTREATMENTEMERGENTSYMPTOMSCALETESSBEFORETREATMENTAND，2，4，6，8WEEKSAFTERTREATMENT．RESUITSTHEBOTHDRUGSWERESIMILARINEFFICACY．THESIDEEFFECTSOFBOTHWERELESS．CONCLUSIONSCITALOPRAMANDMIANSERINAREBOTHEFFECTIVEANDSAFEANTIDEPRESSANTS．【KEYWORDSCITALOPRAM；MIANSERIN；SENILEDEPRESSION为探讨