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HPLC 测定抗癫痫中药! 中四种西药成分血药浓度.pdf

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HPLC 测定抗癫痫中药! 中四种西药成分血药浓度.pdf

¡,•Y3É,ó¦Ì{Ÿv¥embÏD0;hZëµüA¥rª,¦b©nullD¿pnullϪí´,A‚r¿Ó5bÓ´í,AT7|b´.Ï„­,|E7L.Ï„­SbÏ„ªL¡‹´SL­£,´´a|´a|´¹,SLÓ|Ì,¹b´´¹K,SLÓ|¹K,„É7Y‹5®Ûüa•a’Baèa£½aÄPaÀ0aI¥a¹Ca†va£©16ÅÏ0Fî,µmÓaÄ|YŽaœ77LƸe­ÿrbZÏÛüv€ÁÇ­í,7«Ó›,|€ŽY£a¹Ca†v0Ÿÿ¿,»ç,£.ÓÄ|0µrîsŒÓŸ7å¥ÍT¨.ÏSB¯Ø‚ÐLl,2003,912726HPLC©çF–uÏ0ϹÕ0îsÓ0iÿ»»1,Ùòo2,©öV11.Ãg̵Dý,Ã∀300060∀2.Ãg8Dý8ùî,Ã∀300074K∀1∀¥¨ÚrAMäöEH©çF–uÏ0ϹÕ0îsØ1ˆa5”Üaˆ‡„½çÓ0i,5½†aµra†Ø¨0bZE‹¨ÚrAMäöE,¨SymmtryC18äöø,Ö÷ÏAY–6436¹îM,,“_©oÉ214nmb±ÓÏY–æΑâ,bAÉsb²TØ1ˆa5”Üaˆ‡„½çäösÖØX,sY5.050.0a1.012.0a5.025.0„0.102.00mg/LS¶LŸ1z,°„°WÚá5,ÜMílq¹98.65102.64b²‚ZEeLayÎaÚáa’,¨Ó,a¨¿5Í0þS©,¹5¨0¥†Øaµra½†4£b1oM∀HPLC,F–uÏ0,Ó0i,Ø1ˆ,5”Ü,ˆ‡,½çÏmsË|R97∀∀∀ÓDSM’A∀∀∀ÓcI|1006null5687201004null0032null03DeterminationofblooddruglevelsoffourchemicalcomponentsofantiepilepticTraditionalChineseMedicinesbyHPLCYanWeiwei1,LiHuifen2,RenHuiqin11.TianjinHuanhuHospita,lTianjin3000602.TianjinChildren∃sHospita,lTianjin300074ABSTRACTObjectiveTosimultaneouslydeterminetheblooddruglevelsoffourchemicalcomponents,phenobarbita,lcarbamaznullepine,diphenylhydantoinanddiazepam,ofantiepileptictraditionalChinesemedicinepreparationsbyhighperformanceliquidchromatographyHPLC,soastorealizerationalutilizationofthemedicine.MethodsSymmtryC18columnwasemployedasstanulltionaryphaseandthesolutionofphosphatebufferandacetonitrile6436asmobilephase.Thewasdetectedatthewavelengthof214nm.Theproteininbloodwasprecipitatedwithacetonitrile.ResultsPhenobarbita,lcarbamazepine,diphenylhydantoinanddiazepamwerewellseparatedandshowedideallinearcorrelationintherangeof5.050.0,1.012.0,5.025.0and0.102.00mg/Lrespectively.Thedifferencesofprecisionwithinadayandbetweendayswerelowerthan5.Theaveragerelativerenull32Ã0Ð∀Tianjin∀Pharmacy∀2010M∀»22»4ùlà°ù2010null03null11coverywasbetween98.65and102.64.ConclusionThisapproachisconvenient,rapid,sensitive,preciseandaccurate,benullingsuitablefortherapeuticdrugmonitoringTDMandguidingclinicalrationaluseofthedrug.KEYWORDSHPLC,antiepileptic,TraditionalChineseMedicine,blooddruglevels∀∀,áSÿµ–uÑ€600£,ÄMhè65£70£1b–uhö1|0þÍ,“Ñ€E‹ª¹Ï0ý¬T¨l7÷ûiʨÏ0É›Íb–7,Í–u¥BtÏ0Å4ÏÈÈcµ0îs,Ñ€›¨ª,µtÁ3‚Q‹,Oóð5D3F0{Ÿ‚LbyN,îÌBÏ0ɛͥр,ªª³_©ÓAÏBÕÕ0¥0þi,ZL5ÉB„ÍbKȨ¥_©ZE¹ÚrAMäöEbB,50ÐLiÏYȺ¥BûÚrAMäöN,©çÓ0iH,òñZEW¥MÐnHanï,°¤•Yž²h¦¥÷„h¦¨0¥,iO9F‚ýTb¹N,yëBHq/,©çØ1ˆa5”Üaˆ‡„½çÓ0i¥ZE,V¹54eLayÎa’¥çŸç²Tb1∀NÐk01null1∀N∀ÅSWaters³ÚrAMäöN,¥600E˜,,486˜VMoÉ_©,pc800ýT_b1null2∀0Ö„k4∀Ø1ˆ171222200605a5”Ü100142199503aˆ‡100210200401„½ç171225200302vÖÏS0Ö3þÅÖ_çî,5Å5YØ1ˆÖÅSSigma³,Y–aJ¹äöB,ðk4¹sBk4b2∀ZEвT2null1∀äöHq∀äöøSymmtryC18Ñø4.6mm150mm,5nullmîMÖ÷ÏApH6.9ÐY–81¹6436Î1.2ml/min,,“_©oÉ214nmbøÑiÑ,É10nulllb2null2∀ÓbÖØ∀|S€©Ób50null,lFÆ80nulllcSþ5Å5YØ1ˆÖ10mg/L¥Y–A,æΑâ,áÂ,10000r/min֏5min,|bA10nulllÉb¿SE9ØScb2null3∀A¥¥Å2.3.1∀vA¥¥Å∀GQÚáë|Ø1ˆa5”Üaˆ‡„½çvÖ50a25a50„10mg,¨JsY縹1.0a0.5a1.0„0.2g/L¥vA,4ib2.3.2∀vÖ¥Å∀|bâÓbsYFÆØ1ˆa5”Üaˆ‡„½çvA,¥ÅØ1ˆ5.0a10.0a20.0a30.0a40.0„50.0mg/L5”Ü1.0a2.0a4.0a8.0„12.0mg/Lˆ‡5.0a10.0a15.0a20.0„25.0mg/L½ç0.10a0.25a0.50a1.00„2.00mg/Li¥vÓbÖb2null4∀Äk∀äöHq/,Ø1ˆa5”Üaˆ‡a½ç„Sþäö‚sÖrTz,HWsY¹2.98a4.82a5.68a17.63„4.21minbÓbÏ÷ŸþÉ©çí•Y,nm1bäöHq/,YÈ¥ø¥0þ­–aadûÖay.áabºaobºa³aôaØ©É›s,‚ÄØ1ˆa5”Üaˆ‡„½ç¥©çb1.Ø1ˆ∀2.Sþ∀3.5”Ü∀4.ˆ‡∀5.½çm1∀ÓbØ1ˆa5”Üaˆ‡a½çHPLCäöm2null5∀SwL_©K∀|2.3.2/A,vÖÐSþ¥‚Ú1¹USY,i¹˜USXÉ›LŸíBb²TÓbØ1ˆa5”Üaˆ‡„½çsY5.050.0a1.012.0a5.025.0„0.102.00mg/LiS¶LŸ1z,íBZñsY¹Ø1ˆY0.04936X0.009753,r0.99975”ÜY0.08198X0.0007091,r0.9997ˆ‡Y0.04086X0.001901,r0.9996½çY0.07092X0.0009930,r0.9994bÓbØ1ˆa5”Üaˆ‡„½çK®_©isY¹0.1a0.1a0.2„0.05mg/Lb2.6∀Úá„ílq∀k|Ø1ˆ10.0a20.0a40.0mg/L,5”Ü4.0a8.0a12.0mg/L,ˆ‡5.0a10.0a20.0mg/L,½ç0.50,1.00,1.50mg/Lò3Õi¥ÓbS6z,’°©ç,p¤°ÚáE,|ÓbS6z,8d©ç,p¤°WÚáb|BÓbS,FÆ‚¥Ø1ˆa5”Üa33Ã0Ð∀Tianjin∀Pharmacy∀2010M∀»22»4ùˆ‡„½çvÖTílk,¤Ø1ˆa5”Üaˆ‡„½ç¥Mílq,nV1b°„°WÚál¿5,ÜMílq¹98.65102.64,˜†ZEÐ1pbV1∀Úá„ílqk0þimg/L°Úákn6L©´mg/LRSD°WÚákn6L©´mg/LRSDMílqn3L©´mg/LRSDØ1ˆ10.010.06∋0.181.7910.05∋0.232.29101.87∋1.311.2920.019.84∋0.381.9219.88∋0.482.4199.65∋1.511.5240.040.12∋0.521.3140.02∋0.731.8299.54∋0.460.465”Ü4.04.06∋0.051.233.94∋0.061.5298.65∋1.821.828.08.30∋0.131.567.95∋0.101.2698.77∋2.212.2312.012.76∋0.141.1011.81∋0.201.69101.11∋1.881.86ˆ‡5.05.04∋0.112.275.01∋0.122.40101.20∋2.982.9510.010.03∋0.151.4910.10∋0.212.0899.97∋2.762.7620.020.08∋0.271.3519.86∋0.452.27100.18∋2.732.72½ç0.500.53∋0.023.770.49∋0.024.08102.64∋4.124.011.001.01∋0.021.981.01∋0.032.97100.44∋3.443.421.501.51∋0.042.651.43∋0.064.1999.17∋3.323.342.7∀F–uÏ0ϹÕ0îs¥Ó0i_fƒ∀2007M32009M2ýÜSü¥›¨grF–uÏ0Í¥–uÑ€32è,î›Ï0ÃSµF–uÄÐ0Öîs,îµÑ€œñÍùWÛ¨©BÕF–uÄÐ0Ö,É›¹Õ0îs¥Ó0i©ç,_0fƒnV2bV2∀F–uÏ0Ï0îsÓ0i_©²T0Öëè”K®Ó0img/LKÚÓ0img/LØ1ˆ234.541.85”Ü151.77.8ˆ‡80.712.1½ç30.050.163∀‚3null1∀–uh¹ÜS¥Ènh,7080¥–uhVYV†ØaȹóÍBLF–u0þ¤žeÅ1b,F–uÏ0Å4»µ0îsC1ÈnbϤ¥Ñ€µ¨Ï0Í¥,‹n5W³î¨Ï0¥8fƒ,¨0H1InÏ0Ð0¥MºT¨,Ï0ÏVcµ¥0îsb›¨c0îs¥F–uÏ0Ñ€,A¶_©Ó0ib³îc0ÕËŽržÍi,£¨0½†,¹Øœ¨0SbH¬3ÁF–uÏ0¥ÌE,Sü3Á¥0þÏîc0îs,¹5„Ñ€†Øʨ0þ2b3ÁÌE΋InžÏ0Ð0­WVC¥MºT¨,†ØFZ,NÖ–u¥0þÍð5,ÐEç‚A1¥ó†¨0b3null2∀ñÊäöHqH,îMpH¥’çEs1o,’pH†®0.1H,Sþa5”Ü„ˆ‡äö‚†sß,sÖ‚›†b3null3∀Sþ5Å5YØ1ˆÖ,ÄПÉç,Ѐ©þɲM»,»d5Í0þ,BÕØX¥Sþb3null4∀Ø1ˆa5”Üaˆ‡„½çÓ0i©çZEÚáa’asŸ,ílqÚ,äösÖrTz,­ÓD¡¥_©ZE3,4«84|î³µk4,»eÄPë¥4|Vñ,e†ayÎa¨Ó©Äb,¾ZEX¨¿5Í0þS©,¹5¨0¥†Øaµra½†4£b•IÓD1∀¦»ÍöI.ÜhÐ.»4ñ.ئöÏ3ñ,20022242382∀¸Žï,ñ¥¦öI.†Ø¨0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