会员注册 | 登录 | 微信快捷登录 支付宝快捷登录 QQ登录 微博登录 | 帮助中心 人人文库renrendoc.com美如初恋!
站内搜索 百度文库

热门搜索: 直缝焊接机 矿井提升机 循环球式转向器图纸 机器人手爪发展史 管道机器人dwg 动平衡试验台设计

   首页 人人文库网 > 资源分类 > PDF文档下载

ICP-MS 研究中药炮制前后18 种微量元素总量和溶出特性的变化.pdf

  • 资源星级:
  • 资源大小:215.16KB   全文页数:5页
  • 资源格式: PDF        下载权限:注册会员/VIP会员
您还没有登陆,请先登录。登陆后即可下载此文档。
  合作网站登录: 微信快捷登录 支付宝快捷登录   QQ登录   微博登录
友情提示
2:本站资源不支持迅雷下载,请使用浏览器直接下载(不支持QQ浏览器)
3:本站资源下载后的文档和图纸-无水印,预览文档经过压缩,下载后原文更清晰   

ICP-MS 研究中药炮制前后18 种微量元素总量和溶出特性的变化.pdf

ÁÏrSù5ùb2009B032Ï3†ØDýý5BJnull2008null117T€eºÁµf,3,pVnullùîZ_0þsnullnullYßT€±‹,3,ö©0nullnullùîZ_Dý0ÐnullnullTel01085133636nullnullEnullmailhuxinbjyy126nullcomICPnullMSùîÏ0›Åª18Õ±íÍ9„Ÿ¥MÄ金鹏飞1,宋丽洁2,胡欣1,邹定1,吴学军1,孙春华11nullÏ3†ØDý0І,Ø1007302nullØ¿ó†S/Z³,Ø102206K1¥null应用电感耦合等离子体质谱ICPnullMS技术对中药炮制前后18种微量元素的总量及溶出特性的改变进行考察bZEnull应用ICPnullMS技术建立中药中18种元素的同时测定方法,并用该方法对黄芪a大黄a黄芩a何首乌a地黄等5种中药材炮制前后元素总量和水煎过程中溶出特性的改变进行比较和分析b²Tnull测定方法中所有元素的线性相关系数r都大于0null9990,检出限在0null00010null0689nullgnullL1之间,重复性和稳定性的相对标准偏差RSD都小于10,药材的加标回收率在70null89122null4之间,水煎液的加标回收率在74null65130null0之间,标准物质茶叶GBW07605的测定值和其标定值之间有良好的吻合性b测定结果显示,炮制后,微量元素总量的变化因中药品种和炮制方法而异,但各元素的溶出率总体呈现上升的趋势b²‚null中药炮制可改变微量元素的总量和溶出特性b1oM电感耦合等离子体质谱中药炮制微量元素ÏmsË|R284nullnullnullÓDS½’AnullnullnullÓcI|10012494201012089305EffectofProcessingonContentandDissolutionof18TraceElementsinTraditionalChineseMedicinesbyICPnullMSJINPengnullfei1,SONGLinulljie2,HUXin1,ZOUDing1,WUXuenulljun1,SUNChunnullhua11nullPharmaceuticalScienceDepartment,BeijingHospital,Beijing100730,China2nullBeijingHuaxipharmConull,Ltd,Beijing102206,ChinaABSTRACTOBJECTIVEnullToinvestigatecontentanddissolutionfeaturechangesof18traceelementsincrudeandprocessedtradinulltionalChinesemedicinesTCMsbyinductivelycoupledplasmamassspectrometryICPnullMSnullMETHODSnullAnICPnullMSmethodforsimultaneousdeterminationof18traceelementsinTCMswasestablished,andthecontentsanddissolutionfeaturesof18traceelementsin5crudeandprocessedTCMs,RadixAstragal,iRadixetRhizomaRhe,iRadixScutellariae,RadixPolygoniMultifloriandRadixRenullhmanniae,werecomparedandanalyzednullRESULTSnullThevalidatedmethodindicatedthatthecorrelativecoefficientsrforallelenullmentswereabove0null9990nullThelimitsofdetectionswereintherangeoffrom0null0001to0null0689nullgnullL1nullThereproducibilityandstabilityweresatisfactorywithallRSDsbelow10nullThespikedrecoveriesforTCMswerebetween70null89and122null4nullThespikedrecoveriesfortheirwaterextractsolutionsrangedfrom74null65to130null0,thedeterminedvaluesofteareferencematerialGBW07625wereinaccordancewiththosecertifiednullThechangesofelementcontentsdependedontheTCMspeciesandprocessingmethnullods,whilethedissolutionrateofelementsweregenerallyincreasedafterprocessingnullCONCLUSIONnullProcessingTCMcouldchangeitscontentsanddissolutionfeaturesofelementsnullKEYWORDSICPnullMStraditionalChinesemedicineprocesstraceelementnullnullÏ0­îµr,AµþÉbÉùŸ,Ќ¸YÈܵîsT¹Ï00r¥þÉÉ›ùî,7íîs5ªª­{bÛC}DЄ0þÐ¥Z,¦ÌMžÏ0¥0r“V¤m¿µîs„íîs¥xT¨1null2byN,ùîÏ0ÏííÍ¥c,ÂüÏ00r¥þɵ1ilb›ÅÏD¨0¥1Äb¸Ï0ÜV›Åª,0Ÿa0raýŸ©Zëû3¿M,4UþÉ3MÄbI³Ï0›ÅªííÍ¥c,¿ÂüþÉ¥Mĵ1¥•IN´b£Xg›Ï0¥.dó0ZTbÏ0£XAÏ¥þÉŒ‡žÉÆ8¥þÉ,yN,I³£XVñÏòíÍ¥Ÿ¿ùîÏ0¥þÉ9µ1ilbL‹¨ÈËÒ†©Ö08ÉöICPnullMS/Œ,yëÏ0ÏMgaAlaVaCraMnaFeaCoaNiaCuanull893nullÏS0н2010M6»45»12ùnullnullnullnullnullnullnullnullnullnullnullnullnullnullChinPharmJ,2010June,Volnull45Nonull12ZnaAsaSeaMoaCdaSnaBaaHgaPb©18ÕíÍ¥H©çZE,i¨¾ZEÛüavÛaÛùanéa¹Û©5ÕÏ0‹›ÅªíÍc„ŸÉ›dùî,¹ƒtÏ0¥þÉùî4•Ib1nullNÐk0ÈËÒ†©Ö08ÉöNICPnullMSAgilent7500aAgilentTechnologiesConullLtd,USA,BabingtonüÄ,„©|bWX4000Ñâeá±oyÎh³dZsNµK³bÑB£ØdESMILLIPORE,SynthenullsisbMETTLERTOLEDOXP205È0ܼÀ³b101A2˜È£„Ä2QZLN9ÌbRT02A˜xÞØÌðí€/ŒµK³bMgaAlaVaCraMnaFeaCoaNiaCuaZnaAsaSeaMoaCdaSnaBaaHgaPb†íÍSA,Éi1000mgnullL1,1SESþÉùîϏbSþÉSEBSþɯ»|02163,¹ɀÁ†¹oþعoÄаùîîbØAL,iY,Ce,T,lCo†Anull10nullgnullL1,Agilent³ÁÖ,I|5184null3566bSAAgilent†SA6Lia45Sca72Gea89Ya115Ina159Tba209B,inull10mgnullL1,I|5183null4680bibÖMOS30H2O2sBb£¹ÑB£MILLIPOREÑB£dŤb2nullZnullE2null1nullICPnullMS工作参数RFÿq1300W7null8mmÎ1null12Lnullmin1¿î,Î6rnullmin1üÄiÑ2ÄZñEPA200null8TSpecnulltrum,†çíÍ18Õ€©íÍ„7ÕSíÍíÍ¥sHW0null1s,¯Q”3Q¿î,46Î18rnullmin1,46HW30s¿î,Ü™Î6rnullmin1,Ü™HW35sb2null2null中药样品ÛüÁ¹ö,Ø0h³,€h³›†ª,|¤ž¥ÖAMÀ20mLYÖÞÏ,¨ÑB£ç¸ª,,¤b2null6null内标溶液的制备Úá|Agilent†SAa,8s”10bÖAïdîÉi¹0null1mgnullL1¥†A,,¤b2null7null供试品溶液的分析测定和计算N¥S5SÔ¬SAÏ,GQ|N¥Ö5¬Æòñi¥SA“bâAÏÉ›©ç,ÄBi3Q”¥Ü´¹US,M‹¥i¹˜USTSwLb|Ö5¬ÆkÖAÏ,|3Q”¥Ü´,}ÆSwLÏ,9ØM‹¥ib3null²TЂ3null1null方法学验证3null1null1nullLŸ„_Knull€©íÍ„SíÍ¥9”1´¹US,i¹˜US,ûÅ18ÕíÍ¥SwL,iI³LŸM1”rbîµíÍ¥rûv¿0null9990V3bZE_K/T9Ø_KnullgnullL13/SB∀nullbTϹbâAÏòíÍÄð9”´¥Sʵn11null¹òíÍSA¥iS„BsY¹òíÍSA„bâA¥Äð9”´bîµíÍ¥_Kû1nullgnullL1/V3b3null1null2null¯Ÿ„çŸnullLÛü£XA¹}VI³ZE¯ŸÐçŸbÚáë|Ûüxÿ0null2gÛü£XAÿ0null4g,¿2null5∃/¥çT,Ü›L5z,©ç,9ØòíÍc¥Ü´RSDbÛüÖõÃL3d,9Ø3dòíÍcÜ´¥RSDbîµRSDûl¿10,¯Ÿ„çŸzV3,4b3null1null3nullFílqnullLÛü£XA¹}VI³FSílqbÚáë|Ûüxÿ0null2gÛü£XAÿ0null4g¿h³7,iÄ7ÏÚáFÆa¥òíÍAa,¿2null5∃/¥çT,Ü›L5z,©ç,FSª©ç¥cÜ´9ØòíÍ¥ílqV4b0‹ÏòíÍ¥ílq70null89122null4­W,£XAÏòíÍ¥ílq74null65130null0­WbV2null供试品的消解程序Tabnull2nullMicrowavedigestionprocedureforsamplesStepsTempnull/Presnull/kPaHoldtime/min1601null01∀103521001null21∀103531501null52∀1031042002null03∀10310V3null18种微量元素线性a检出限和稳定性nulln3Tabnull3nullLinearity,LOD,andstabilityof18traceelementssnulln3ElementInternalisotopeCalibrationcurverrLOD/nullgnullL1StabilityRSD/24Mg6LiY11null10null11370null99990null06892null2427Al6LiY8null204null85null090null99990null00251null5051V72GeY0null533null0null2770null99990null00026null4053Cr45ScY25null82null0null2670null99980null00264null6755Mn45ScY4null000null9null8090null99940null00053null1957Fe45ScY191null2null288null70null99930null01902null7559Co45ScY3null534null0null1390null99970null00073null4560Ni72GeY15null74null0null8490null99980null00032null3563Cu72GeY1null193null0null6740null99990null00161null4166Zn72GeY8null242null16null580null99900null00285null4675As72GeY6null623null0null0780null99990null00116null3382Se72GeY101null9null2null5450null99970null01494null3695Mo89YY19null89null0null4850null99960null00022null64111Cd115InY37null01null0null0070null99930null00024null37118Sn115InY11null60null0null1801null00000null00033null60137Ba159TbY44null53null18null790null99930null00022null67202Hg209BiY16null57null0null0600null99930null00302null24208Pb209BiY7null574null0null8090null99950null00011null48null895nullÏS0н2010M6»45»12ùnullnullnullnullnullnullnullnullnullnullnullnullnullnullChinPharmJ,2010June,Volnull45Nonull12V4null18种微量元素重复性和准确度Tabnull4nullReproducibilityandaccuracyof18traceelementElementReproducibilityRSD/Recovery/TeareferencematerialTCMWaterextractTCMWaterextractCertified/nullgnullg1n5,xsFound/nullgnullg1Mg4.022.24107.8112.717002001650Al3.59UD93.56108.0300012260V3.785.3977.99102.50.8610.85Cr3.805.9170.8986.630.80.030.828Mn4.322.8686.4574.651240701224Fe3.42UD92.78113.626415250Co4.954.2790.53113.90.180.020.16Ni4.412.1496.69111.34.60.54.7Cu4.073.2385.2797.3617.31.819.0Zn5.453.4185.8895.3426.32.024.7As5.375.2995.51130.00.280.040.26Se8.367.51102.8101.10.07210.118Mo7.034.0480.25104.40.0380.0070.041Cd6.076.6778.1886.030.0570.0100.052Sn4.036.8996.06107.8ND0.281Ba7.57UD122.4125.258655Hg8.908.5079.54114.40.01310.021Pb2.394.7283.63101.04.40.34.3ÿUDÃ_NDÃç1A,lV,Se,Hg¥c¹•I´NoteUDundetectableNDnotdefined1ThevaluesforA,lV,Se,Hgwerenotcertifiedvalues,butreferencevalues3null1null4nullSþÉ£null¨SEBSþɯGBW07605ZE’É›ÉB„£bÚáë|Sþɯÿ0null2g,¿2null5∃/¥çT,Ü›L5z,©ç,9ØòíÍc¥Ü´V4bòíÍ¥©ç´ûS´ç¥S¶b3null2null样品测定及结果分析‹¨yë¥ZEÛüavÛaÛùanéa¹Û©5ÕÏ0‹›ÅªíÍc¥MÄ„£XªòíÍ¥ŸÉ›ùîbÄñÖÜ›L5zn5,|Ü´b©ç²TnV5,6b18ÕíÍÏ,AsaCdaHgaPbaCu¦8¥²v,òSEÉgÏ0‹Ïƒ5ÕíÍ¥KÚ¸cûµü’¥çb0¨±þÅ4sä›Sç4ÉgÏ0Å4ÏAs¥c‹∋2nullgnullg1,Cd¥c‹∋0null3nullgnullg1,Hg¥c‹∋0null2nullgnullg1,Pb¥c‹∋5nullgnullg1,Cu¥c‹∋20nullgnullg1bVÛüavÛaÛùanéa¹Û¥ð0›ÅÖ¥©ç²TŸA,5ÕíÍ¥cû˜†1pbné›Åª,¬îµíÍ¥cûC9Ú¹ۛŪ,”íÍ¥cC9ÚvÛ„Ûù›Åª,c9Ú„†®¥í͔M’7Ûü›Åª,”íÍ¥cûC/†bƒü4U,Ï0›Åª,òíÍc¹3MÄ,Œ‚¥Ï0ÖÕ,‚¥›ÅZE,MÄt9ò‚MbµÓD5null6¡,›ÅªíÍc¥MÄV„0Ÿ­WµM1ŸíÍc9F,0Ÿüt¿Ñ£ŸíÍch,0Ÿüt¿eŸbL¥Ï0ÖÕµK,y79íE¾Ø‚É›ÉB„¥£bVíÍŸŸAîµÖÏAlaVaCraFeaBa¥qû“®,4UƒtíÍV£‚Ÿíÿi,9V„«ŸµÄÐîs™î£‚Ÿ¥Ž†þb‚ÖÏNiaCuaZnaSeaMo¥qµY“v,4UƒtíÍ‚Ï0Ï¥i™T‚b∗Ûü›ÅªHgaCu©ñYíÍ“,ðíÍ¥qûC6Ûù„¹ۛŪ,q6¥í͔¿q/†¥í͔vÛ„né›Åª,q9Ú„†®¥í͔M’bƒüªü,Ï0›Åª,íÍ¥q98ïC6tbnull896nullChinPharmJ,2010June,Volnull45Nonull12nullnullnullnullnullnullnullnullnullnullnullnullnullÏS0н2010M6»45»12ùV5null元素总量测定结果nullnullgnullg1Tabnull5nullResultsofelementcontentsnullnullgnullg1ElementRadixAstragaliRadixetRhizomaRheiRadixScutellariaeRadixPolygoniMultifloriRadixRehmanniaeCrudeProcessedCrudeProcessedCrudeProcessedCrudeProcessedCrudeProcessedMg162012262808165448435775732949925882Al24613930057987339999.4169765744V0.390.220.400.851.910.820.100.261.191.24Cr2.621.122.204.494.342.660.951.613.054.82Mn13.79.4727.915.322.516.17.559.7313.515.4Fe27427834758166332471.3195570631Co0.210.120.220.300.500.290.100.160.330.38Ni2.791.932.174.332.871.500.621.362.133.41Cu5.654.764.052.937.227.823.044.032.783.52Zn24.629.615.28.8313.313.510.022.98.9113.7As0.150.101.280.370.470.100.040.110.810.52Se0.120.040.560.250.070.030.010.030.670.83Mo3.605.410.090.050.040.130.060.280.030.02Cd0.030.010.090.050.020.020.030.040.030.02Sn0.040.040.060.200.070.060.100.060.090.10Ba5.852.8612968.960.364.64.969.049.729.84Hg0.050.040.060.040.100.100.020.030.030.01Pb0.470.390.510.870.920.920.480.721.181.53V6null元素溶出率测定结果nullTabnull6nullResultsofelementdissolutionratesnullElementRadixAstragaliRadixetRhizomaRheiRadixScutellariaeRadixPolygoniMultifloriRadixRehmanniaeCrudeProcessedCrudeProcessedCrudeProcessedCrudeProcessedCrudeProcessedMg56.583.166.780.768.365.647.689.369.470.3AlUD1.1716.310.80.910.687.4519.45.079.67V4.727.603.931.781.400.538.982.326.1017.5Cr16.926.620.612.47.9915.321.922.313.59.88Mn38.855.837.850.333.648.158.774.743.043.5FeUD8.525.9615.21.332.158.6615.317.921.2Co41.454.244.029.421.636.947.968.842.947.4Ni57.571.974.730.617.620.875.751.841.222.4Cu82.356.358.242.729.137.984.045.057.761.3Zn37.438.790.994.638.966.710488.569.866.5As52.482.578.590.159.174.487.489.478.482.9Se35.346.413.45.2025.582.584.767.023.023.4Mo10584.37.895.269.506.2717.39.5384.577.0Cd23.446.528.145.320.033.526.543.326.638.7Sn73.878.284.029.663.576.782.788.154.442.6BaUDUD3.854.7928.236.729.848.214.611.5Hg37.623.376.620.047.434.561.121.143.054.5Pb37.466.636.665.236.850.953.238.719.231.0ÿUDÃ_NoteUDundetectableREFERENCES1nullCHAOZQnullRecentprogressandprospectofthestudyontraceelnullementsintraditionalChinesemedicineJnullGuangdongTraceElenullmentsSciê±íÍSÐ,1997,479null16null2nullCHAOZQ,WANGXP,CHAOGZ,etalnullStudiesonrelationbetweenbiologicalactivityandspeciationoftraceelementsintranullditionalChinesemedicineJnullGuangdongTraceElementsSciê±íÍSÐ,1995,21018null26null3nullChnullP2005VolÏS0Å2005MñnullB†Snull2005appendix20null21null4nullWM/T2null2004.Greenstandardsofmedicinalplantsandpreparanulltionsforforeigntradeandeconomy0¨±þÅ4sä›SSnull20041null2null5nullQIJS,XUHB,ZHOUJY,etalnullStudiesontheamountoftraceelementsandfourcharacteristicsinprescriptionsofChinesemedinullcineJnullJAnalScisSÐÐ,1998,144283null287null6nullWUZX,HUKF,MAWnullStudiesontherelationshipsbetweeneffectoftraditionalChinesemedicineandtraceelementsbeforeandafterprocessingJnullStudTraceElementsHealth±íÍÐrBùî,2003,20135null36nulllà°ù2009null09null11null897nullÏS0н2010M6»45»12ùnullnullnullnullnullnullnullnullnullnullnullnullnullnullChinPharmJ,2010June,Volnull45Nonull12

注意事项

本文(ICP-MS 研究中药炮制前后18 种微量元素总量和溶出特性的变化.pdf)为本站会员(abaodong)主动上传,人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对上载内容本身不做任何修改或编辑。 若此文所含内容侵犯了您的版权或隐私,请立即通知人人文库网([email protected]),我们立即给予删除!

温馨提示:如果因为网速或其他原因下载失败请重新下载,重复下载不扣分。

copyright@ 2015-2017 人人文库网网站版权所有
苏ICP备12009002号-5