NF-κBSignalingInteractivePathway

Kinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-protein Acetylase Deacetylase Ribosomal subunit Direct Stimulatory Modification Direct Inhibitory Modification Multistep Stimulatory Modification Multistep Inhibitory Modification Tentative Stimulatory Modification Tentative Inhibitory Modification Separation of Subunits or Cleavage Products Joining of Subunits Translocation Transcriptional Stimulatory Modification Transcriptional Inhibitory Modification CELL SIGNALING TECHNOLOGY Pathway Diagram Keys ub TRADD TRAF6 TRAF6 Pellino -TrCP TAK1 JNK ub TAB1/2 ub A20 RNF11 MyD88 IL-1R IKK IKK/ NEMO IKK IKK/ NEMO RIP Tax cIAP1/2 -TrCP GF-Rs TRAF2/5 TNFR Ras Cot Akt PI3K PDK1 ub TRAF3 LTR, CD40, BR3 NIK TRAF2 TRAF2/6 IKK IKK ub RelB NF-B2 p100 ub IKK IKK RelB NF-B2 p52 RelB NF-B2 p52 H3 PARP1 IKK IKK NAP1 PCAF ac IKK/ NEMO ATM SUMO SUMO IKK/ NEMO NAK HDAC PIAS CBP/ p300 RSK1 PKA CCK2 NF-B p50/52 p65/ RelA NF-B p50/52 p65/ RelA GSK-3 MSK1 IKK/ PKC RelA/cRel NF-B1 p50 IB/IB NF-B2 p52 p65/ RelA ub p38 CK2 NF-B1 p50 RelA/cRel IB/ NF-B p50/52 NF-B p50/52 Bcl-3 CYLD ub ub ub ub ub ub ITCHTAX1BP1 TAK1 TAB2/3 ELKS ubc13 IB IRAK1/4 Ubc13 LUBAC UEV1A Proteasomal Degradation Survival, Proliferation, Inflammation, Immune Regulation Lymphogenesis, B Cell Maturation Proteasomal Processing Genotoxic Stress Stress: ROIs, UV, metals, ischemia, shear K48-ubiquitin K63-ubiquitin ub IL-1 LT, CD40L, BAFF/BLys Growth Factors: BMP, EGF, HGH, Insulin, NGF, TGF- TNF UV Nucleus Cytoplasm ub Nuclear-cytoplasmic shuttling of non- phosphorylated forms For detailed signaling, see BCR Pathway. BCR Ag TCR Ag-MHC For detailed signaling, see TCR Pathway. TLRs LPS, CpG, ssRNA, dsRNA For detaile