Toll-likeReceptors(TLRs)InteractivePathway

Kinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-protein Acetylase Deacetylase Ribosomal subunit Direct Stimulatory Modification Direct Inhibitory Modification Multistep Stimulatory Modification Multistep Inhibitory Modification Tentative Stimulatory Modification Tentative Inhibitory Modification Separation of Subunits or Cleavage Products Joining of Subunits Translocation Transcriptional Stimulatory Modification Transcriptional Inhibitory Modification CELL SIGNALING TECHNOLOGY Pathway Diagram Keys E n d o s o m e MD-2 TRAM TRIF TIRAPMyD88 TIRAP MyD88 TIRAP MyD88 MyD88MyD88 IRAK-4 IRAK-M IRAK-1IRAK-2 TLR4 TLR4 CD14 TLR5 TLR5 TLR11 TLR11 TLR1 TLR2 TLR6 TLR2 IKK IKK TBK1 IKK/ NEMO IKK IB ub MyD88 TLR9 TLR9 MyD88MyD88 TLR7 TLR8 TLR3 TLR3 TRIF p65/RelA NF-B IRF-7 IRF-7 IRF-3 IRF-3 ECSIT A20 TOLLIP RIP1 RIG-I MAVS TRAF3 ST2L SOCS1 TRIAD3A TAK1 TAB1/2 JNK p38 MAPK MKK 3/6 MKK 4/7 FADDCasp-8 MEKK-1 TRAF6 Ubc13 UEV1A LPS CpGdsRNA dsRNA or 5-triphosphate RNA ATP Flagellin Uropathogenic Bacteria, Profilin Diacyl Lipopeptide Triacyl Lipopeptide Proteasomal Degradation Apoptosis Transcription Factors Inflammation, Immune Regulation, Survival, Proliferation Nucleus Anti-viral Compounds, ssRNA Anti-viral Compounds, ssRNA Cytoplasm T