TNF superfamily_Wallchart 2013

Fas CD95 6 FasL CD95L; CD178 TRAIL-R1 DR4; CD261 10A TRAIL Apo-2L; CD253 10 TNF-R1 CD120a 1A TNF- 1LT TNF- 2 TNF-R2 CD120b 1B TRAIL-R2 DR5; CD262 10B TRAIL-R3 DcR1; CD263 TRAIL-R4 DcR2; CD26410D 6 DR3 TRAMP 12 CD137 4-1BB 9 OX40 CD134 4 CD30 Ki-1 8 CD27 GITR AITR; CD357 18 BCMA CD269 17 15TL1A VEGI HVEM CD270 14 OPG RANK CD265 11B BTLA CD272 11RANKL TRANCE; CD254 DcR3 6B14LIGHT CD258 12 TWEAK CD40 5 TACI CD267 13B BAFF-R BR3; CD268 13C XEDAR 27 EDAR NGFR p75; CD27116 7 IGFLR1 TMEM149 11A 3LT LT12LTR 7CD27L CD70 8CD30L CD153 5CD40L CD154 9CD137L 4-1BBL 4OX40L CD134L; CD252 18GITRL AITRL; TL6 13APRIL CD256 13B 20 BAFF BLyS; THANK; CD257 EDA-A2 EDA-A1 RELT 19L TROY TAJ 19? ? NGF IGFLs TRAF1 binding TRAF2 binding TRAF3 binding TRAF4 binding TRAF5 binding TRAF6 binding Death domain 10 16 Matrilysin Metalloproteinase (TACE) Furin TNFSF number TNFRSF number GPi Inhibition 10C DR6 CD35821N-APP Death domain truncated Fn14 TWEAK-R; CD26612A TNF homology domain (THD) Cysteine rich domain (CRD) 3 TNF Superfamily Ligands & Receptors Adipogen International Schtzenstrasse 12 ? CH-4410 Liestal ? Switzerland TEL: +41-61-926-60-40 ? FAX: +41-61-926-60-49 E-Mail: ? JUL 2013 SPECIES CROSS-REACTIVITIES TNF LIGANDSLIGANDS TRAIL Apo-L2 FasL CD95L TNF-? LT? TNF-? TL1A VEGI TWEAK LIGHT LT?LT?1? BTLA RANKL TRANCE CD27L CD70 CD30L CD153 CD40L CD154 CD137L 4-1BBL OX40L CD134L GITRL AITRL APRIL BAFF EDA-A2 EDA-A1 NGF N-APP IGFLs hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms hu ms TNF RECEPTORS TRAIL-R1 DR4 hu TRAIL-R2 DR5 hu ms TRAIL-R3 DcR1 DcTRAIL-R1 hu ms TRAIL-R4 DcR2 DcTRAIL-R2 hu ms Fas CD95 hu ms TNF-R1 hu ms TNF-R2 hu ms DR3 TRAMP hu ms Fn14 TWEAK-R hu ms DcR3 hu ms LT?R hu ms HVEM hu ms OPG hu ms RANK hu ms CD27 hu ms CD30 Ki-1 hu ms CD40 hu ms CD137 4-1BB hu ms OX40 CD134 hu ms GITR AITR hu ms BCMA hu ms TACI hu ms BAFF-R BR3 hu ms XEDAR hu ms EDAR hu ms NGFR p75 hu ms DR6 hu ms IGFLR1 hu ms =