北大神经生物学课件2绪论.ppt

Threshold (mA) of afferent fibers activated by EA (HANS) at different frequencies,A,0,1,2,3,4,5,6,7,2 Hz 0.6 ms,15 Hz 0.3 ms,100 Hz 0.2 ms,Types of nerve fibers,*,Threshold of excitation,(mA),A,A,C,Effect of HANS on heart rate of heroin addicts,Day of treatment,1,2,3,4,5,6,7,8,9,10,CRAVING: the most difficult issue,一朝吸毒，终身想毒。,1 Month,0,50,100,Relapse Rate (%),*,*,* P0.05, compared with BPN group,92%,78%,57%,71%,100%,100%,HANS Decreases Heroin Relapse Rate of the Heroin addicts,2 Month,3 Month,BPN (n=12),HANS+BPN (n=14),*,Morphine-induced conditioned place preference (CPP) Dose-dependent effect,No relapse over 1 year,No relapse over 1 year 一年不复吸,Aim: HANS detox. + HANS ready in the pocket 30% success over 1 year,Opiate craving,Suppression of drug craving by HANS,Cocaine craving,2 Hz 100 Hz,100 Hz 2 Hz,Electroacupuncture treatment for drug addiction,A,100 bp,2000 bp,1000 bp,750 bp,500 bp,250 bp,DL 2000,NS,CPP,2 Hz,100 Hz,restrain,GAPDH (532 bp),PPD (250 bp),Effect of 100Hz EA on the level of PPD mRNA in NAc of CPP rats,B,Effect of 2Hz EA on the level of PPE mRNA in NAc of CPP rats,2000 bp,1000 bp,750 bp,500 bp,250 bp,100 bp,DL2000,CPP,2 Hz,100 Hz,restrain,GAPDH（532 bp）,PPE（402 bp）,NS,美国权威性“物质滥用”教科书 Joyce Lowinson 等主编 第4版，2004 “针刺戒毒”一章 由韩济生编写,肥胖的发展趋势,肥胖发病机理,Genes,Environmental factors,HANS治疗肥胖症：人体研究结果,梁门，一对。 天枢，一对。 水道，一对。 梁丘，公孙。 频率：2/100 Hz 每周3次 每次30 分钟,大鼠实验结果（高能食物引起肥胖）,Diet-induced Obesity (DIO) After 14 weeks,促进摄食和抑制摄食的神经肽,大鼠实验结果（体重%）,大鼠实验结果（体重差值）,* P0.001 vs. DIO; # p0.01, # P0.001 vs. Restriction,大鼠实验结果（ACTH）,大鼠实验结果（能量摄取）,CART -MSH,Control,Diet induced Obesity,Diet Resistant,Restrain,100Hz,2Hz,CART immunoreactivity in hypothalamus,大鼠实验结果（免疫组化）,n = 5,国际神经科学领域：英国TiNS杂志（2003） 国际针灸领域：德国SEIRIN针灸奖（2002） 国际戒毒理论：美国“物质成瘾”经典教科书 临床戒毒实践：韩氏戒毒一年以上不复吸20例,36年针灸研究，12年戒毒研究 所获成绩,Trends in Neuroscience, 2003; 26: 17-22,International SIERIN Acup