ICP-MS 研究中药炮制前后18 种微量元素总量和溶出特性的变化.pdfICP-MS 研究中药炮制前后18 种微量元素总量和溶出特性的变化.pdf

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RS5B2009B032;3†D5BJNULL2008NULL117T€EF,3,PVNULLZ_0SNULLNULLYT€‹,3,0NULLNULLZ_D0NULLNULLTEL01085133636NULLNULLENULLMAILHUXINBJYY126NULLCOMICPNULLMS0›189„ŸM金鹏飞1,宋丽洁2,胡欣1,邹定1,吴学军1,孙春华11NULL3†D0†,100730;2NULL†S/Z,102206K1NULL应用电感耦合等离子体质谱ICPNULLMS技术对中药炮制前后18种微量元素的总量及溶出特性的改变进行考察BZENULL应用ICPNULLMS技术建立中药中18种元素的同时测定方法,并用该方法对黄芪A大黄A黄芩A何首乌A地黄等5种中药材炮制前后元素总量和水煎过程中溶出特性的改变进行比较和分析BTNULL测定方法中所有元素的线性相关系数R都大于0NULL9990,检出限在0NULL00010NULL0689NULLGNULLL1之间,重复性和稳定性的相对标准偏差RSD都小于10,药材的加标回收率在70NULL89122NULL4之间,水煎液的加标回收率在74NULL65130NULL0之间,标准物质茶叶GBW07605的测定值和其标定值之间有良好的吻合性B测定结果显示,炮制后,微量元素总量的变化因中药品种和炮制方法而异,但各元素的溶出率总体呈现上升的趋势B‚NULL中药炮制可改变微量元素的总量和溶出特性B1OM电感耦合等离子体质谱;中药;炮制;微量元素MS|R284NULLNULLNULLDS’ANULLNULLNULLCI|10012494201012089305EFFECTOFPROCESSINGONCONTENTANDDISSOLUTIONOF18TRACEELEMENTSINTRADITIONALCHINESEMEDICINESBYICPNULLMSJINPENGNULLFEI1,SONGLINULLJIE2,HUXIN1,ZOUDING1,WUXUENULLJUN1,SUNCHUNNULLHUA11NULLPHARMACEUTICALSCIENCEDEPARTMENT,BEIJINGHOSPITAL,BEIJING100730,CHINA;2NULLBEIJINGHUAXIPHARMCONULL,LTD,BEIJING102206,CHINAABSTRACTOBJECTIVENULLTOINVESTIGATECONTENTANDDISSOLUTIONFEATURECHANGESOF18TRACEELEMENTSINCRUDEANDPROCESSEDTRADINULLTIONALCHINESEMEDICINESTCMSBYINDUCTIVELYCOUPLEDPLASMAMASSSPECTROMETRYICPNULLMSNULLMETHODSNULLANICPNULLMSMETHODFORSIMULTANEOUSDETERMINATIONOF18TRACEELEMENTSINTCMSWASESTABLISHED,ANDTHECONTENTSANDDISSOLUTIONFEATURESOF18TRACEELEMENTSIN5CRUDEANDPROCESSEDTCMS,RADIXASTRAGAL,IRADIXETRHIZOMARHE,IRADIXSCUTELLARIAE,RADIXPOLYGONIMULTIFLORIANDRADIXRENULLHMANNIAE,WERECOMPAREDANDANALYZEDNULLRESULTSNULLTHEVALIDATEDMETHODINDICATEDTHATTHECORRELATIVECOEFFICIENTSRFORALLELENULLMENTSWEREABOVE0NULL9990NULLTHELIMITSOFDETECTIONSWEREINTHERANGEOFFROM0NULL0001TO0NULL0689NULLGNULLL1NULLTHEREPRODUCIBILITYANDSTABILITYWERESATISFACTORYWITHALLRSDSBELOW10NULLTHESPIKEDRECOVERIESFORTCMSWEREBETWEEN70NULL89AND122NULL4NULLTHESPIKEDRECOVERIESFORTHEIRWATEREXTRACTSOLUTIONSRANGEDFROM74NULL65TO130NULL0,THEDETERMINEDVALUESOFTEAREFERENCEMATERIALGBW07625WEREINACCORDANCEWITHTHOSECERTIFIEDNULLTHECHANGESOFELEMENTCONTENTSDEPENDEDONTHETCMSPECIESANDPROCESSINGMETHNULLODS,WHILETHEDISSOLUTIONRATEOFELEMENTSWEREGENERALLYINCREASEDAFTERPROCESSINGNULLCONCLUSIONNULLPROCESSINGTCMCOULDCHANGEITSCONTENTSANDDISSOLUTIONFEATURESOFELEMENTSNULLKEYWORDSICPNULLMS;TRADITIONALCHINESEMEDICINE;PROCESS;TRACEELEMENTNULLNULL0R,ABŸ,ŒYST00R›,7S5{BC}D„0Z,„Mž00R“VMS„SXT1NULL2BYN,0C,00R1ILB›D01B0V›,0ŸA0RAŸZ3M,4U3MBI0›C,M1•INBXG›0D0ZTB0XAŒ‡ž8,YN,IXVŸ091ILBL‹†08ICPNULLMS/Œ,Y0MGAALAVACRAMNAFEACOANIACUANULL893NULLS02010M64512NULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLCHINPHARMJ,2010JUNE,VOLNULL45NONULL12ZNAASASEAMOACDASNABAAHGAPB18HZE,IZEAVAANA50‹›C„Ÿ›D,ƒT04•IB1NULLNK0†08NICPNULLMSAGILENT7500AAGILENTTECHNOLOGIESCONULLLTD,USA,BABINGTON,„|BWX4000EOYHDZSNKBBDESMILLIPORE,SYNTHENULLSISBMETTLERTOLEDOXP2050B101A2˜„2QZLN9BRT02A˜X€/ŒKBMGAALAVACRAMNAFEACOANIACUAZNAASASEAMOACDASNABAAHGAPB†SA,I1000MGNULLL1,1SESBSSEBS|02163,€†OOBAL,IY,CE,T,LCO†ANULL10NULLGNULLL1,AGILENT,I|5184NULL3566BSAAGILENT†SA6LIA45SCA72GEA89YA115INA159TBA209B,INULL10MGNULLL1,I|5183NULL4680BIBMOS30H2O2SBBBMILLIPOREBDB2NULLZNULLE2NULL1NULLICPNULLMS工作参数RFQ1300W;7NULL8MM;1NULL12LNULLMIN1;,6RNULLMIN1;I2;ZEPA200NULL8;TSPECNULLTRUM,†;18€„7S;SHW0NULL1S,Q”3Q;,4618RNULLMIN1,46HW30S;,™6RNULLMIN1,™HW35SB2NULL2NULL中药样品,;0K,|06011704;V,‚K3,|601000032;,‚K3,|601000325;N„,;0K,|0601018;,‚K3,|601000017B|,VE3‚TM,BƒV|VV,VE3“‘,B|,VE3,BN|N,‘V•E3•“5,,M,2;100GN,‘10GBƒ|3,VE3,|,“AH,M,2;100G3,40GBXX,V700,Q702,2B2NULL3NULL中药水煎液的制备|010G,FB300MLž1H,MM40MINB,4ƒRB,20MLB23QBRF200ML,MM20MIN,VRTB†I2QRA,HI,BD20G,B2NULL4NULL标准溶液的制备|18€SAA,510BAA,8S”10BAM‹IV1B2FSA†BF,17BFB8S”10BATBABV1NULL标准曲线质量浓度系列NULLNULLGNULLL1TABNULL1NULLCONCENTRATIONOFCALIBRATIONCURVESNULLNULLGNULLL1ELEMENTMG∀104A,LFE∀103VCRMNCO,SEAS,SNNICUZNMOCDBA∀102HGPBBLANK00000000000000STD11051550055105010205052STD215122010011020100504114STD322550150215501501008228STD4154151003004301003005015410STD530103020060086020060010021020NULL894NULLCHINPHARMJ,2010JUNE,VOLNULL45NONULL12NULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLNULLS02010M645122NULL5NULL供试品溶液的制备|0X0NULL2GXA0NULL4G,H7,FIB3ML,30H2O2A2ML,,HVBFIB2ML,|/V2›H,€H›†,|žAM20MLY,B,,B2NULL6NULL内标溶液的制备|AGILENT†SAA,8S”10BADI0NULL1MGNULLL1†A,,B2NULL7NULL供试品溶液的分析测定和计算NS5SSA,GQ|N5ISA“BA›,BI3Q”US,M‹I˜USTSWLB|5KA,|3Q”,}SWL,9M‹IB3NULLT‚3NULL1NULL方法学验证3NULL1NULL1NULLLŸ„_KNULL€„S9”1US,I˜US,18SWL,IILŸM1”RBRV0NULL9990V3BZE_K/T9_KNULLGNULLL13/SB∀NULLBTBA9”SN11;NULLSAI;S„BSYSA„BA9”B_K1NULLGNULLL1/V3B3NULL1NULL2NULLŸ„ŸNULLLXA}VIZEŸŸB|X0NULL2GXA0NULL4G,2NULL5∃/T,›L5Z,,9CRSDBL3D,93DCRSDBRSDL10,Ÿ„ŸZV3,4B3NULL1NULL3NULLFLQNULLLXA}VIFSLQB|X0NULL2GXA0NULL4GH7,I7FAAA,2NULL5∃/T,›L5Z,,FSC9LQV4B0‹LQ70NULL89122NULL4W,XALQ74NULL65130NULL0WBV2NULL供试品的消解程序TABNULL2NULLMICROWAVEDIGESTIONPROCEDUREFORSAMPLESSTEPSTEMPNULL/PRESNULL/KPAHOLDTIME/MIN1601NULL01∀103521001NULL21∀103531501NULL52∀1031042002NULL03∀10310V3NULL18种微量元素线性A检出限和稳定性NULLN3TABNULL3NULLLINEARITY,LOD,ANDSTABILITYOF18TRACEELEMENTSSNULLN3ELEMENTINTERNALISOTOPECALIBRATIONCURVERRLOD/NULLGNULLL1STABILITYRSD/24MG6LIY11NULL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