TAC, TEC 方案新辅助化疗治疗乳腺癌效果比较[J].pdf

TACaTECZFrT1Y,_*,fnull,!null(天津医科大学附属肿瘤医院,天津300060)nullnullK1:null1TACaTECZFrbZEnull139?F,sTACF71TECF68,sYTAC(+1+)Z#TEC(+V1+)Z46,4?a?%M#Q?3fbTnullTACF9rq(RR)ahq(pCR)a5q(cCR)a5sq(cPR)#hf(SD)qsY88.7%a11.3%a28.2%a60.6%11.3%,TECFsY86.8%a10.3%a26.5%a60.3%13.2%,FM1P(0.05bVF%/alhaLa#a/?s?3qM1P(0.05bTACFQ(0|s)?3q46.5%,TECF66.2%(P0.05).Insideeffects,includingleukopenia,thrombocytopenia,constipation,cardiotoxity,abnormalityandhepatorenaldysfunction,therewasalsonosignificantdifference(P0.05).Onlythegastroentericreactionincludingnauseaandvomiting,theTACgroup(46.5%)lowertoTECgroup(66.2%)(P80s,-YV#BaXL&amaAs#/?_,)M#aa/#?pbsTACF71TECF68b1.2nullZEnullTACF75mg/m2aTHP40mg/m2aCTX500mg/m2,bTECF75mg/m2aEPI60mg/m2aCTX500mg/m2,b21d1,46bV?,-/?mbC%hH%Oy0(GnullCSF)bWC0a|sQ5)b-m-5rQb461014d,r%mb1.3nullrQSnullUICCrS1r,5N|8_()mb?h5(cCR),?KvKvh50%5s(cPR),?KvKvhl50%9Fl25%hf(SD),?KvKv0.05bTACF59-%M44(74.6%)%|,TECF55-%M42(76.4%)%|,F%|qM1P0.05bF1393=(F,mMq100%bTACF?3Q(0|s)33(C23d,i12d)；TECF?3Q45,O?VC,aVr34d,FM1P0.05b3null)FB&%h,*V?3l,AY$&b；?l?,ehM,-s,V?P.lMe,h)M；yymh,-Ve?Z1b6YV4-rTV,#4GbV,?%,7O?%r#3iq1M2bYVrpCR1rpCRDh3iq93iq3,4bx0$FKr0B,ADM#,5svKbTHPxF?0,ADMQ3,bmMqr100%bTACaTECZFr7ibOx0#21D02011M516QVs,TECF0|saHWb#3TACaTECZF?#?%M1(r,OQV0s,THPEPIVTF?0bID:1f.FJ.?,2003,25(5):209null211.2ChuthapisithS,BeanBE,CowleyG,eta.lAnnexinsinhumanbreastcancer:PossiblepredictorsofpathologicalresponsetoneoadnulljuvantchemotherapyJ.EurJCancer,2009,45(7):1274null1281.3vanderHageJA,vandeVeldeCJ,JulienJP,eta.lPreoperativechemotherapyinprimaryoperablebreastcancer:resultsfromtheeunullropeanorganizationforresearchandtreatmentofcancertrial10902J.JClinOnco,l2001,19(22):4224null4237.4RastogiP,AndersonSJ,BearHD,eta.lPreoperativechemotheranullpy:updatesofNationalSurgicalAdjuvantBreastandBowelProjectProtocolsBnull18andBnull27J.JClinOnco,l2008,26(5):778null785.5SpielmannM,KerbratP,DelozierT,eta.lPirarubicininadvancedbreastcancer:aFrenchcooperativephasenullstudyJ.EurJCancer,1990,26(7):821null823.6BermanE.Newdrugsinacutemyelogenousleukemia:areviewJ.JClinPharmaco,l1992,32(4):296null309.(l:2010null12null15)25#*2?40r4,null,Unull(开封市第一人民医院,河南开封475000)nullnull2009M52010M5,25#*2?40,rTzbC/b5:#*2?80,33l,o49；M-2560,(40.54；hN3,(S*psS1#*2?SbYVa8_2amh%ha#5d%h,2_k3haha#h#?,PkaVP43/#Pi/_,H*pb|sFvF,40bZE:F(?$g,ba1bFF25(5c2)0.33g),3Q,Q3,30minb(8b,(,FF*h0bT:FAr(5a-u.eaC#hh)27,r(5a-u.eaC#hA,?Tqh,HW；sh,)11,r(5a-u.eaC#hA)2,9rq95.0%；vFsY14a17a9#77.5%bF9rq1,P0.05bF-q:V(HAMD)s(16.74#6.25)a(5.62#5.13)s,vF(17.14#5.91)a(9.42#3.97)s,F-1,P0.05；F1,P0.05bFV?3ga0aaahe1,vF?3gahe1,(S+y)bF?a/?-(AMb):l4ws7,FnaFy+bs8F4,v41Fl(s8,?；l41Tl(-1&s8(D2s8),db,Pl(W#c9FbwVl(-J/F(NE)#5nullHT|T,4l(W#cbyN,0T14l(W#aNE#5nullHT*c,w*d?；VFwFaT,hQb251s2)x,s?2)M,*