淀粉样变治疗学研究的最新进展.pdf淀粉样变治疗学研究的最新进展.pdf

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CLINICALOUTCOMEOFPATIENTSWITHADVANCEDNONSMALLCELLLUNGCANCERTREATEDWITHEPIDERMALGROWTHFACTORRECEPTORTYROSINEKINULLNASEINHIBITORSJINTJCANCER,2008,122112612262017NULLOHARAG,KURISHIMAK,ISHIKAWAH,ETALKL6ANDPOORPROGNOSISINNSCLCPATIENTSTREATEDWITHGEFITINIBJLUNGCANCER,2008,591818718NULLMATSUMURAK,NIKII,TIANH,ETALRADIOIMMUNOSCINTIGRAPHYOFPANCREATICCANCERINTUMORBEARINGATHYMICNUDEMICEUSING99MTECHNETIUMLABELEDANTIKL6/MUC1ANTIBODYJRADIATMED,2008,26313313919NULLTOKIYAR,HIRATSUKAJ,YOSHIDAK,ETALEVALUATIONOFSERUMKL6ASAPREDICTIVEMARKEROFRADIATIONPNEUMONITISINPATIENTSWITHBREASTCONSERVATIONTHERAPYJINTJCLINONCO,L2004,9649850220NULLMATSUNOY,SATOHH,ISHIKAWAH,ETALSIMULTANEOUSMEASURENULLMENTSOFKL6ANDSPDINPATIENTSUNDERGOINGTHORACICRADIONULLTHERAPYJMEDONCO,L2006,231758221NULLKONGFM,AOX,WANGL,ETALTHEUSEOFBLOODBIOMARKERSTOPREDICTRADIATIONLUNGTOXICITYAPOTENTIALSTRATEGYTOINDIVIDUALIZETHORACICRADIATIONTHERAPYJCANCERCONTRO,L2008,152140150编校田媛淀粉样变治疗学研究的最新进展王学文RECENTPROGRESSOFRESEARCHONTHERAPEUTICSOFAMYLOIDOSISWANGXUEWENDEPARTMENTOFHEMATOLOGY,NANJINGGENERALHOSPITALOFNANJINGMILITARYCOMMAND,NANJING210002,CHINANULLABSTRACTNULLDURINGTHEPAST10TO15YEARS,THEREHASBEENSUBSTANTIALPROGRESSINDEVELOPINGNEWTREATMENTSFORTHESYSTEMICAMYLOIDOSISTHESEADVANCESHAVEIMPROVEDPATIENTOUTCOMESBUTHAVEALSORAISEDNEWQUESTIONSWITHDIRECTCLINICALIMPLICATIONSFOREXAMPLE,DEVELOPMENTOFLESSINTENSIVETREATMENTSFORALAMYLOIDOSISHASMADELESSCERTAINTHEROLEOFAUTOLOGOUSSTEMCELLTRANSPLANTATION,ANDNEWQUANTITATIVEASSAYSSHOULDNOWALLOWDETERMINATIONOFTHEIMNULLPORTANCEOFFULLYELIMINATINGAMYLOIDOGENICLIGHTCHAINPRODUCTIONINALDISEASEADDITIONALLY,OBSERVATIONSFROMACLINICALTRIALINAAAMYLOIDOSISHAVEGENERATEDHYPOTHESESABOUTTHERELATIVECONTRIBUTIONSOFAMYLOIDPRECURSORSANDMATUREFIBRILSTOAMYLOIDOSISASSOCIATEDKIDNEYDISEASENULLKEYWORDSNULLAMYLOIDOSIS;FREELIGHTCHAIN;MELPHALAN/DEXAMETHASONEMEL/DEX;STEMCELLTRANSPLANTATION;TARGETEDTHERAPYMODERNONCOLOGY2011,190101720176NULLUŸK1NULL;1015MDŸXMZ|LŸZBƒTZ€B,ŒG{Ÿ55B,XALXM18/MT‚\,Nž7WO„4KDBCX8„ƒ8\PXMM12HM,AU›†BALXM€\XAMYLOIDOGENIC31Ÿ,HTX8‘„2HMSSBNULL1OMNULLXM;;E;;18M;_NULLMS|NULLR73021NULLNULLNULLNULLDSM’NULLANULLNULLNULLNULLDOI103969/JISSN1672499220110164NULLCI|NULL16724992201101017205NULLNULLXMHN/„BŸXM‚IB,NPH€Bž,–5‚CB‚„XMS˜„2AQ‹S,NULLLNULLNULL20100322NULLT€†NULLNULL2U29DAS,NULL2NULL210002NULLT€ENULLNULL1940,3,,Q,D,1VYAH5TBEMAILXUEWENWANG1939SINACOMZ5B1NULLXMS˜„2AQ‹S40MX8SšP5,†XHO‘H„XMW1‚BX8S‘F,Œ‚9B˜,„XM8‘25BXMS„XM8‘T,‚˜XM8‘„2‚NV11BŒ‚XM˜›M‹BTXMS„_NULL172NULLMODERNONCOLOGY,JANNULL2011,VOINULL19,NONULL01–|‚BXMˆQ10/NULLM,“1015IALXMŸMMFO‘WM€2BAL€30NULL32SA/A/„“D,V”1221,3V1B73˜JF‘TTR„XMNMDŸXMSSA,GLM˜TTRXMLŸXMKNY3B4‘Z{LMTTRY,122S9}VAL122LLEBTTR1,ŽW3BLMPTTR8‘,79FS\XMAMYLOIDOGENIC†8I4BI73˜TTR™X8,ISSAB33ŸG–‚3BYVY73˜TTR†LM˜ATTR„SSAB0DIFLUNISAL„FX1006A8“„88„ATTRTž5KBS2ALXM2„Q‹SNV25BA„5Q‹SAMEL/DEXNULL3,SCT3I3€B2NULLXMKDKALXMDŸXMKN„ZK3,6B15MHQPEMELPHALAN,MELFDMPZBEHN›†BHŸ†XHFO‘3,A•Y3IBS1990M}NB4E140200MG/M218MAUTOSCT,XB›†AQ‹NM’1€7BV1NULLDŸXMN˜XM˜8‘†XALNULLNULLA/A/GIAPNSAFJF‘XMATTRLM˜JF‘APNSMD˜73˜JF‘AAKAPNSXA8AABXA8/8‘XMAFIBLM8‘A/AAPOA1XMAPO‘A1A/A/GIAPNSA‘注GI胃肠道;PNS外周神经系统;AA很罕见,但仍发生在慢性感染A严重痛风A溃疡性结肠炎和转移性肾癌BV2NULL2A2„AQ‹S52NULL/24HU‘05G/D,‘NULLUIC12MM,HVDNULL915CMšFƒ/,BAŸ15žKNULL/Ÿ“HMA†BPALŸEA21†BSNULL„_’NULLK„_’,W˜ŸB˜NULLF9VA1HA‘,”AHLŸGV_LAA58†˜2Q‹NULLIWH2MMAS”20A2GXS7‚9FU4„CNULL/24HU‘H50H05G/D05G/D,„•BQ0‚25NULLSAH50,B•UVLH2CMNULLMHNAHFQ‹›†Q‹F_B„U†XH‘|ŸA/FLC1žABFLCž/‚†€NULL†SQ‹BMS05G/DL„H50;U‚100MG/D„H50;FLC10MG/DL„H50NULL›†Q‹ZV†XH‘FLC1QSNULL†SQ‹Q‹ZBM‘9F5005G/DLUM‘9F50‚200MG/D;FLC9F5010MG/DLNULL›†Q‹A†SQ‹ZNULLNULL2S˜€‹FHM1ŸP5DžPBALXM€V4„AUTOSCTM1QTAM1MM0Ÿ€8BXM/ŒWIV4E„SCTHDM/SCTT4Ÿ€BL9BHDM/SCT9}G›E022MG/KGNULLDV440MG/DMEL/DEX4DB6BMEL/DEXY†XH3„YHN7UTBNP,€XMM1SSB‚L,‚3AHBYN,HDM/SCTB€MEL/DEX‚†ABŒHDDEXV{ŸM1A8AAM„H,RžAQ‹K‚GZŒ6BIALXMKD;SCT‹4˜†S€6,MTRMC5,ORB14HDM/SCT„MEL/DEXTKMRTCP‚H6B3NULLALXM31NULLMDEX„ASCTALXM1MDEX„ASCTALXMKW‹NULL173NULLC}DNULL2011M01NULL1901ZE3,6,1011BJACCARD12ESXM18SCTF29NULLKSAL€žHDMEL/SCT„MEL/DEXF50BMEL/DEXF”3IZ,13/50SCT€ZVSME,L9SCTBSS3INULL6€SCTAUMBMEL/DEXFQ‹Q68,”3I569,HDM/SCTF222P004B65›†AQ‹QSY32„41,ŒS‚ABT€‚HDM/SCTI‚MEL/DEXB‚ASCTAQ‹MžL10BY|MEL/DEXTALS,ŒG›MEL393S„ŸHBIBMMIIALG›MEL„DEXMDEX„HDNULLMELAUTOSCTSBKKMDEXAQ‹„3IQSCT3B‚HDM/SCT€B9F7M9FB’DƒTCH5AFIN,50ALXM37SžHDM/SCTF,74SE200MG/M2BHDM/SCTFTAM2412,XM†M14146,9BQV€S„I‚˜†HDM/SCTHQK6B32NULLXM€AUTOSCT†SBXM€AUTOSCT†S10NULLS†XTFECOG801;NULL‚VGXNYHAIIIš;NULLX‘‚V22;NULLMNULL65;NULL•BNULL08ML/S50ML/MIN;NULL‰NULL15„ALPNULL2NULLžK;NULL_IC„PICNULL15MM;NULLX‘M11HMŒC51Ÿ;NULLX‘M1ŒC51ŸB€A˜†††SCTS,SAU††˜†€TRMB,XM€SCT†S3C121ALVEFNULL45AKNULL50„LNULL90MMHGBVƒTS1/3€˜†SCTHQBB,NSCTA„2Q‹V33B33NULLZŸALXM37‚A†SCTZŸALXM13,MDEX9Q‹Q,ŒQ‹€”3I22B1Q‹€ŸHBX22ZŸ€MDEXTHALQ‹€”3I2414BMQ,347ALXM€51Q‹€”3I702BƒTL23IM11YI„Q‹BXM€M˜Z4VSCTBBXMSD’€‚A9TROPONINT„UAHVA8„HŸFLCUTRM1516BMRIUSXM„GŸHBE›M€‚R,YV‚Q‹VAHM,4‹INžŸSCT‚•Y,EE†,XM–M{B‘CALRETICULINVR1†‘,CR€1CR€SCT}CA,BY,ŒQŸ’BV3NULLNVSCT€B3T€”TRMRR/CR2Q‹”3IMMEL200/HGERTZ200731216NA/27264656/44SKINNER20042701171/33NANR67/33GOODMAN2006922337/20NA5369/31VESOLE20061072732/1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