多西他赛联合洛铂治疗蒽环类耐药的晚期乳腺癌疗效分析.pdf多西他赛联合洛铂治疗蒽环类耐药的晚期乳腺癌疗效分析.pdf

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多西他赛联合洛铂治疗蒽环类耐药的晚期乳腺癌疗效分析张NULL彦1,刘英光2,孙NULL红1CLINICALOBSERVATIONOFDOCETAXELPLUSLOBAPLATININTREATINGANTHRACYCLINESRESISTANTADNULLVANCEDBREASTCANCERZHANGYAN1,LIUYINGGUANG2,SUNHONG11DEPARTMENTOFQNCOLOGY,QINGDAOMUNICIPALHOSPITAL,QINGDAO266011,CHINA;2DEPARTMENTOFGYNAECOLOGY,PINGDUPEOPLESHOSPITAL,PINGDU,266700,CHINANULLABSTRACTNULLOBJECTIVETOOBSERVETHECURATIVEEFFECTANDTOXICITYOFDOCETAXELPLUSLOBAPLATININADVANCEDBREASTCANCERPATIENTSWHOWEREDRUGFASTINUSINGANTHRACENENUCLEUSDRUGSMETHODSFORTYTWOFEMALEPATIENTSRECEIVEDDOCETAXEL75MG/M2ONDLANDLOBAPLATIN30MG/M2OND1OFEVERY21DAYSEVERYPATIENTWASADMINISTEREDATLEAST2CYCLESRESULTSFOURPATIENTSACHIEVEDCOMPLETERESPONSEAND19PARTIALRESPONSE,THEOVERALLRESPONSERATEWAS548,ONEYEARSURVIVALRATEWAS642,THEMAINSIDEEFFECTWASMARROWSURPRESSIONCONCLUSIONCOMBINEDCHEMOTHERAPYOFDOCETAXELANDLOBAPLATINHASAGOODANTITUMORACTIVITYANDMANAGEABLETOXICITYONADVANCEDBREASTCANCERPATIENTSWHOWEREDRUGFASTINUSINGANTHRACENENUCLEUSDRUGSNULLKEYWORDSBREASTCANCER;DOCETAXE;LLOBAPLATIN;COMBINEDCHEMOTHERAPYMODERNONCOLOGY2011,190304730474NULLK1NULL4†ŒSZX00žF€5RTBZE†ŒSZžF€42B75MG/M21,ŒS30MG/M21B21,‹2BT42€,CRAPRSY4A19,9RQ54823/42,1M3IQ64327/42,1‚Q‹B‚†ŒSZX00žFRZ,‚Q‹,X00žFZZBNULL1OMF;;ŒS†NULLMS|R7379NULLNULLNULLNULLDSM’ANULLNULLNULLNULLDOI103969/JISSN1672499220110322NULLCI|16724992201103047302NULLNULLCXZFBLZ,ŒX0žF€,SZBL0“,AA5„SB12006M6Ÿ,†ŒSZžF€42,C|T/B1NULL‹ZE11NULLH4HLžF€,M60,KPS70S,93IV3;/AAMž,V5CTAMRI4S,VHBFX0žF€,“1CX0Z6CMNULLLNULL20100705NULLNULL20100831NULLT€†NULL1›GGDS,NULL›NULL2660112GDS,NULLNULL266700NULLT€ENULLF1974,O,›,D,V,1VYF8†BNULLYT€NULL1965,O,›,D,1VYSBEMAILKADINAZHANG163COM;2žFCX0Z2RB12NULLB12006M62008M1LX00žF€42,OŸ,MS246O,M48B18429,24571B1›FŒ,MCTAMRI’,M37A†FAC16AKM11AM7A7M11AM13,BF2M29,M10,3;S8ER„/PRŸ27,|Ÿ14,‚W1;HER2/NEUS8Ÿ16,Ÿ|Ÿ23,‚W3B13NULLZE75MG/M21LH,1,ŒS30MG/M2,13LH,€2B5HT3S8E4Ÿ“S,€GCSFB211Q,2,HZC‚SŸ,CR2B2NR,12B14NSRWHOL8RSS›†CRA†SPRASD„ZPDBRQCRPRD9,3IV7SQHWBHW7SA€HWBŸQ‹WHOŸQ‹SS0IVB2NULLT21NULL5R†ŒSZ42žH,›134,H32BHVN,CR4,PR19,SD11,PD8,RQ54823/42,1M3IQ64327/42B22NULL‚Q‹Z1‚Q‹VI,AŸKN,LHBDAŸ,N0A|S,AA/Ÿ1N,M1ŸB8NV1BV1NULL†ŒS42žF‚Q‹TAB1NULLADVERSEEVENTSOCCURREDINTHE42ADVANCEDBREASTCANCERPANULLTIENTSAFTERTREATMENTWITHDOCETAXELPLUSLOBAPLATINADVERSEEVENTSGRADE0GRADEGRADEGRADE∃GRADELEUCOCYTOPENIA1471371THROMBOPENIA1112973NAUSEA/VOMIT8191230LIVERDISFUNCTION345300KIDNEYDISFUNCTION392100HEARTDISFUNCTION411000FATIGUE927510ALOPECIA03523113NULL‚CX0ZXFŒAŒMŸFSZ,X00ž€,5ŒCSLZB†MŸF1ZEB,0žFKR0BBB†,F0BYV5‘†,\5‘5I,P5‘”AH,V7S„9BDV,TL0,†0VF€3I,ORC†1BŒS}SF0,FTYV™PTGG„PTAGŒ,EDNA„CV,V7›2BSM1,ŒSA/Ÿ,‚1,ŸA9Ÿ„HQ‹1S,4KŸLH,5SM3B5AU,ŒSF”S5SB{ŒS†0MFRQ4524,AŠŒS†žFRQ4245B1ŒS†X00žF“,S16BFT4U,†ŒSX00žFZR,RQ548,1M3IQ643,‚Q‹,Œ1ILH,L/†,B‚{L,HQ‹,6“9N”€B9,†ŒSFZSX0MžFL,RZ,TL,0SŸZ,B„BNULL•ID1NULLI,‚0ZMMŸF54JC}D,2010,1822962982NULLSPARANOJATAXANESFORBREASTCANCERANEVIDENCEBASEDREVIEWOFRANDOMIZEDPHASEANDPHASE∃TRIALSJCLINBREASTCANCNULLER,2000,132403NULLSARISCP,VANDEVAARTPJ,RIETBROEKRC,ETALINVITROFORMATIONOFDNAADDUCTSBYCISPLATIN,LOBAPLATINANDOXALIPLATININCALFTHYMUSDNAINSOLUTIONANDINCULTUREDHUMANCELLSJCARCINOGENESIS,1996,1712276327694NULL‚,U|OŒS5ZJ5,2006,1175495525NULLZ,ˆC,,ŒSASSY†9F—,ž1C}D,2008,1610174317446NULL{,Z,,ŒS†0F5JL,1998,1342942957NULLAŠ,芃,冯继锋,等洛铂联合长春瑞滨治疗晚期乳腺癌335RJ5,2006,11128878948NULL,;,,†ŒSF15RSJ2YVD,2008,2803233编校田媛
编号:201312191610498157    类型:共享资源    大小:81.70KB    格式:PDF    上传时间:2013-12-19
  
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