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G2/M检验点调控机制研究概述A1A2A3G2/MA0A4A5A6A7A8A9A10DNAA11A12A13A14A15A16A17A18A19A20A21A22A13A23A24A25A26A27A28A29A30A31A32A33A34A13A35A36A29CDC2CDK1CYCLINBA37A38A39A30G2/MA40A41A36A42A43A13A27A44A45A46A29CDC2CDK1CYCLINBA13A47A48A49A50A51A45A52A13A42A53A29A54A55G2/MA40A41A36A42A53A56A57A13A33A34A54A58A59A25A60A61A62A63A64A65A64A65A66G2/MA40A41A36A67CYCLINBA67CDC2A67CDC25ABSTRACTA68G2A69MCELLCYCLECHECKPOINTSISTHEFINALHURDLETOPREVENTACELLWITHDNADAMAGEFROMGOINGINTOMITOSISA70ANDISCURRENTLYONAHOTTHECOMPLEXOFCDC2CDK1CYCLINBISTHEKEYFACTOROFTHEG2/MCELLCYCLECHECKPOINTSTHEACTIVITYOFCDC2CDK1CYCLINBISREGULATEDBYMANYFACTORSTHISOVERVIEWWOULDEXPLAINTHESTATUSQUOOFMODULATINGMECHANISMOFG2/MCELLCYCLECHECKPOINTSKEYWORDSA68G2A69MCELLCYCLECHECKPOINTSA71CYCLINBA71CDC2A71CDC25A72A73A74A75A76A77A78A79A80A72A73A81A82A83A84A85A79A80A86A87A88A89A82A83A84A85A79A80A86A87A90A91A92A93A94A95A96A97A70A98A99A79A100GLA75A101SA75A101G2A75A102MA75A70A103A104A105A106A107A108A109A110A111A112A113A114A115A112A116A117A118A119A120A121A122A123A124A125A109A126A103G1/SA127G2/MA128A115A129A130A131A132SA128A115A133A134A135A136A137A138A139A140A141A142A115A121A143A144A145A124A125A115A146A147A116A148A122A149A150A151A152A153A154A149A147A138A155A156A157A126A158A128A115A133A117A159A160A161A124A125A111A162A152A163A164A156A165A139A166A164A167A115A168A128A169A170A171CELLCYCLECHECKPOINTSA172A1511A121A169A170A171A173A174A169A175A171A176A169A177A171A178A179A180CHECKPOINTA121DNAA181A182A179A180DNADAMAGECHECKPOINTSA136A183DNAA181A182A184A111A115A185A161A124A125A168A128A186A187A178A188A189A115A112A117A141A142A190A191A121DNAA181A182A179A180A152A192A136DNAA181A182A193A194A195A115A113A164A141A142A190A191A126A196A136A103A122A123A112A158A197A198A155A193A199A164A115A112A117A119A120A190A191A126A200A192A159A103A111A112DNAA181A182A201A104A202A203A204A153A205A206A121A207A202A208A209A210A131A184A211DNAA181A182A196A212A213A214A215A216A208A217A112A218A219A220A221A176A222A223A178A218A224A225A226A227DNAA181A182A228A184A111A207A202A124A125A119A120A126A229A230DNAA231A150A176A124A125A168A128A186A187A178A188A189A176A124A125A232A233A234A121A235A109A124A125A168A128A186A187A178A188A189A136A236A159DNAA181A182A169A175A171A237A238A115A121DNAA181A182A169A175A171A239A240A229A230G1/SA169A175A171A176SA169A175A171A127G2/MA169A175A171A121G2/MA128DNAA181A182A169A175A171A115A203A204A136A188A241A242A164DNAA181A182A115A124A125A133A243A164A244A245A246A128A115A212A201A156A247A179A180A227A248A249A181A182A115A250A251A192A252A126A245A253A194A195ATMCHK2CDC25A127ATRCHK1CDC25A254A255A236A1792A126A182A151CDC2CDK1CYCLINBA115A195A11A126A188A241A124A125A133A243MA128A121CDC2CDK1CYCLINBA150A32A116A136G2/MA169A175A171A141A1A115A179A0A208A2A126A183A207A108A179A216A208A3A4A5A236A159A6A7A178A127A7A8A9CYCLINB1CDC2A195A11A178A114A40A10A12G2/MA169A175A171A141A142A203A204A121A169A175A171A172A151A115A13A123A228A214A215A168A128A141A142A115A13A123A133A196A210A214A215A124A125A115A149A14A11A15A16A126A161A117A17A111A112A1211CDC2CDK1/CYCLINB1DNAA89A18A19A20A21A26ATM/ATRCHKL/CHK2CDC25A/B/CA77A22A23A24A25A27A28A29A30A31A33A34A35A31A26A36A37A26A204CDKCYCLINA38A39A41A42A43A44A45A26A208A46A47A48A49A50A23A51A52A55A82A53A54A56A57A58A59A60A61A212A82A62A63A177A64A58A59A65A66A67A68A69A70A71A72A73CDKA100A74A63A177A64A58A59A65A66A67A68CYCLINA61A75A63A177A64A58A59A65A66A76A78A79A80A81A83A61A58A59A65A66A64A63A177A76A78A84A85A86A64CDKCYCLINA87A88A57A90A63A1773A55CYCLINB1CDC2A87A88A57A91A92A93A94A95A96A97A79A98A99MPFA61A101G2/MA66A102A103A104A64A105A106A81A107A98A99A61A221A58A59A82G2A66A108A109DNAA110A111A112A61G2/MA66DNAA110A111A102A103A104A113A114A115A116CYCLINB1CDC2A87A88A57A64A118A71A119A120A121A79A122A93A94A95A96A61A123A124A58A59A65A66A79A125A61A126A119A128A58A59A93A129A130A64A112A131A132A87A110A111A64DNAA61A100A133A134A135A98A136A64A137A138A71A5511CDC2A139A140A141A142G2/MA143A144A145A143A144CDC2A146A147A148A150A151A152A161A153A154A155A156A157A158A159A160A162A163A164A152A165A166A167A151A162A168A169A170A171A172CDC2A173A174A175A176A176A232A178A180A181A180A181A184A185A186A187A188A189A190A191A192A233A193A194A195A192A196A197A198A199A172YASUIA2004A201WESTERNBLOTA202A203A205A235A206A169A207A209A206A210CDC2A211A174A175A213A192A207A214A174A215A216CDC2A211A174A175A213A217A218A219A180A181A220A192A222A223A224A193A225A226A172A227A228A206A229A230A192LIA2005A249A231CDC2A22770A211A228A206A234A236A210A173A174A175A172A222A202A203A174A215A216CDC2A237A238A227A239A240A253A241A242A243A199A210A188A244A245A246A247A201A192A248A250A251A252CDC2A237A238A211A174A175A254A255A150A180A181A194A195A192A128A0G2/MA5A1326A172A204A3A1A203A2A79A192CDC2A173A174A175A254A75A4A180A181A6A173G2/MA7A8A9A17212CYCLINB1A10A11A12A13A12A13G2/MA14A15A16A15A16A82A17A18A252A19A20A21A22A23A24A25A26A210A27A236A80A66A28A29A236A80A30A236A80A31A32A236A80A33A45A22A80A34A35A22A80A185A36A37A20A23A24A25A87A38A39A40A41A42CYCLINB1A43A44A46A47A48A44A46A47A43CYCLINB1A144A49A50A51A52A53A54A55A48A137A56A168MRNAA57A58A59A241A60A48A61MRNAA57A58A43A62A63A64A65A67A184A68A57A58A62A63A69A70A240A71A48A46A240CYCLINB1A43A72A73A7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