[生物医药论文精品]一种脱缩硫醛或缩硫酮保护基的新方法

一种脱缩硫醛或缩硫酮保护基的新方法A1A0A3A4A2A6A5A7A8A9A10A11A12A13A14A15A16A13A14A17A2A2A18A19A18A19A21A20A22A2A13A14A15A16A13A14A17A23A8A9A10A11A24A25A11A26A27A28A29A3050A32A33A31A34A35A36312HA38A39A37A41A40A42A13A14A15A16A13A14A17A43A36A2A15A16A17A45A46A44A476886A38A39A48A50A7A8A9A10A11A24A25A11A49A51A52A53A54A55A12A13A14A15A16A13A14A17A56A57A58A60A18A19A38A61A59A62A3A13A14A15A13A14A17A12A56A57A8A9A10A11ABSTRACTANEWMETHODWHICHCANBEUSEDFORTHESELECTIVEDEPROTECTIONOFEITHERTHIOACETALSORTHIOKETALSAREREPORTEDTHENEWMETHODINVOLVESTREATMENTWITHPPAPOLYPHOSPHOUSACIDINACETICACIDAT2550A32,ANDREPRESENTSAVALIDALTERNATIVETOTHEEXISTINGMETHODSKEYWORDSTHIOACTALSTHIOAKETALSDEPROTECTIONPOLYPHOSPHORICACIDA13A14A15A16A13A14A17A52A53A54A55A56A57A43A36A2A63A58A64A20A65A2A18A19A66A67A68A69A65A20A22A26A54A55A70A0A2A18A19A38A13A14A15A16A13A14A17A71A52A53A72A43A36A2A63A58A73A74A35A75A64A20A65A23A67A68A20A22A26A67A76A70A0A2A7A77A38A79A66A13A14A15A16A13A17A78A80A56A57A58A81A22A43A36A2A63A58A64A20A65A82A83A23A54A84A2A85A86A45A88A88A87A0A50A7A70A89A91A45A92A64A24A90A58A641A94A38A95A93A96A97A98A99A54A55A60A100A2A12A13A15A16A17A56A57A2A18A19A38A102A18A19A101A7PPAA104A8A9A10A11A105A23A25A11A2A83A23A34A27A28A29A4050A32A35A36A38A106A103A67A2A18A19A107A108A45A96A97A98A99A2A18A19A33A31A29A24A45A110A52A109A111A45A113A7A112A114A115A116A117A41A45A46A44A27A103A67A18A19A43A118A381A120A119A121A12211A124A123A106A112A114A113A7A112A114A125A53A126A127A64A128A129A16A122A130A129A112A114A38A132A131A133A134A124A3BRUKERARX300MHZA136A137A135A124VGZABHSA139A45A140A138A141A84A124A3ZMD1A139A142A143A140A138A141A84A124A104A29A86A144A145A146A147A105A3812A120A119A18A19A13A14A15A16A13A14A17A148A149A150A151A18A19A20A222A45A21A20A22A2A13A14A15A16A13A14A17A106PPAA23A25A11A2A83A23A34A45A27A28A29A4050A32A35A36A35A363A4012HA45A153A20A22A152A1541A38A156A155A64A20A65A2A65A157A74A137A24A46A44A153A1581A38SCHEME1SYTHESISOFTHIOACETALSORTHIOKETAL2ANDDEPROTECTIONOF2REAGENTSANDCONDITIONSABF3ET2O,CH2CL2,624H,RT,BPPA,ACOH,2550A32,312HA156A155A2A35A36A18A19A51A64A20A652FA2A12A56A57A35A36A53A159A3A161A64A20A652E200MGA45PPA28GA45A25A1135MLA45A28A29A34A160A1628HA38TLCA164A163A165A166A138A35A36A167A169A38A170A35A36A168A20A65A26A171A172A173A1742050MLA45A176A7A173A175A177A29A45A30PPAA179A121A122A178A45A181A180A7CH2CL2A183A161A10410ML3A105A45A20A176CH2CL2A183A161A182A180A7NA2SO4A185A184A186A187A38A189A188A80A78NA2SO4A180A190A75A191A192A194A78A193A114A45A196A195A65A197A198A130A122A199A129A64A104A201A200A202A25A11A25A20351A105A38TAB1DEPROTECTIONOFTHIOACETALSORTHIOKETALSTOCARBONYLCOMPOUNDSTHIOACETALSTHIOKETALSDEPROTECTIONYELDMPLITMPA2041HNMRCDCL3,A205PPMMSESI2A681051071151163189719951H,M,CH2213422101H,M,CH2286929422H,M,SCH2301631142H,M,SCH238033H,S,OCH351441H,S,CH684768962H,DD,ARH,J69737974192H,DD,ARH,J692B627476123312833H,T,J75,CH3191220001H,M,CH2214222181H,M,CH2260622822H,Q,J75,CH2CH3287829512H,M,CH2302531232H,M,CH251631H,S,CH716871952H,D,J81,ARH737974062H,D,J81,ARHM2412C73113115202321131H,M,CH2226123381H,M,CH2299830712H,M,CH2312432212H,M,CH253291H,S,CH759076441H,T,J84,ARH789279281H,M,ARH824082791H,M,ARH844384571H,Q,ARHM2422D35373435418091H,S,CH3,191920002H,M,CH2271927764H,M,CH2724773031H,M,ARH736174212H,M,ARH793479702H,M,ARH2E8239404054155141814772H,Q,CH2157716484H,M,CH2192820046H,M,CH2277128124H,M,CH22F86120122164620371H,M,CH2212822101H,M,CH2256226162H,M,CH2264027616H,M,CH2315232532H,M,CH238453H,S,OCH339203H,S,OCH365211H,S,ARH74831H,S,ARHM2972G841101121144198520612H,M,CH2278728254H,M,SCH2725573123H,M,ARH733073914H,M,ARH770377283H,D,ARH2H83119121198720172H,M,CH2277228174H,M,SCH238123H,S,OCH338523H,S,OCH338943H,S,OCH3681068863H,M,ARH739774041H,D,J21,ARH755875882H,D,J9,ARHM3632A206A207A208A209A210A211A212A213A214A215A216A217A218A219A220A221A222A223A224A225A226A227A228A211A229A208A230A231A232A233A234A235A236A237A238PPAA208A239A240A241A220A242A243A244A245A246A247A248A249A250A218A251A252A253A254A231A232A233A255A21A236A97A0A215A255A21A218A251A252A227A210A1A2A3A214A4A5A218A6A7A8A218A9A10A11A231A12A13A14A15A218A16A17A227A48A230A231A218A212A213A18A19A20A227A210A1A22A23A228A224A225A24A228A25A26A27A11A231A9A10A227A210A28A228A4A5A14A29A218A9A10A227A222A223A46A30A225A31A236A231A32A33A251A252A34A7A210A240A35A36A218A228A8A34A7A37A38A238A236A2A3A69A39A40A5A16A17A214A236REFERENCES1MBALOGH,ACORNELISANDPLASZLO,TETRAHEDRONLETT,31,33131984IDEGANI,RFOCHIANDVREGONDI,SYNTHESIS51198