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抗骨质疏松产品骨元肽结肠靶向胶囊的综合评价（之一）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,A230A218189512DA231A232A233685A234A235A225A236A2374HA238A239A240A241A242A243A244A2294961A245A246A247A248A226A227A228A238A239A249A250A251A252A253A254A255A6A209A115A0A211A7A224A126A1A211A212A213A226A118A2A209A146A147A218A3A4A5A226A7A8A9A10A11A12A13A14A15A246A16A17A18A19A20A21A22A23A24A25A26A27A100A28A19A29A30A31A100A32A33A34A35A85A36A37A38A39A47R9A158A40A41A42A43A44AA158A45A46A48A44COMPREHENSIVEEVALUATIONONCOLONTARGETINGCAPSULEOFGUYUANPEPTIDEFORANTIOSTEOPOROSISPRODUCTLIYANPINGA49LIUYIA49WUKEFENGA49DENGYIFENGA49AICHUNMEIA49GONGXIANLINGA49LVYINGNIANA49CUILIAOA50GUANGDONGKEYLABORATORYFORRESEARCHANDDEVELOPMENTOFNATURALDRUGSA51ZHANJIANG524023A52CHINAA53ABSTRACTOBJECTIVETOPERFORMCOMPREHENSIVEEVALUATIONONCOLONTARGETINGCAPSULEOFGUYUANPEPTIDEA54GYPA55FORANTIOSTEOPOROSISACTIONMETHODSINVITROANTIOSTEOPOROSISPRODUCTWASINVESTIGATEDBYMTTMETHOD,DETECTINGALKALINEPHOSPHATASEALKANDMINERALIZEDNODESINOSTEOBLASTSFROMSDRATSINVIVOTHERATMODELSOFOSTEOPOROSISWEREINDUCEDBYOVARIECTOMYANDTREATEDWITHTHREEDOSESOFCOLONTARGETINGCAPSULEOFGYP50,200,800MGKG1D1THESERUMLEVELSOFESTRADIOLE2,OSTEOCALCINBGP,TRANSFORMINGGROWTHFACTORSTGF1ANDALK,BONEMINERALDENSITYBMD,ANDTHECONTENTSOFCALCIUMCAANDPHOSPHORUSPIN24HURINEWEREDETECTEDTHEDISTRIBUTIONANDABSORPTIONOFGYPSMWINTHECOLONOFRATSWEREALSOINVESTIGATEDRESULTSGYPENHANCEDCELLPROLIFERATION,ALKACTIVITYANDTHENUMBEROFMINERALIZEDNODESINRATSOSTEOBLASTSTHECOLONTARGETINGCAPSULEOFGYPWERESIGNIFICANTLYINCREASEDTHESERUMLEVELOFE2A56TGF1A56ANDBMDA56DECREASEDTHESERUMLEVELOFALK,BGPANDTHECONTENTSOFCAA56PIN24HURINE,ANDTHECAPSULESHADNOSIDEEFFECTSANDTHESHELFLIFEOFTHEMREACHED24MONTHSTHEMWOFGYPISBETWEEN1891000D,INWHICHTHECOMPONENTOF189512DTAKES685ORABOVETHEAVERAGEABSORPTIONRATEIS4961A57INTHECOLONOFRATSCONCLUSIONTHECOLONTARGETINGCAPSULEOFGUYUANPEPTIDEISANEFFECTIVEANDSAFEPRODUCTWITHCONTROLLABLEQUALITYFORBMDENHANCEMENT,PREVENTIONANDCONTROLOFOSTEOPOROSISINMIDDLEAGEDANDSENILEGROUPSKEYWORDSA58COLONTARGETINGCAPSULEOFGUYUANPEPTIDEA59GYPA60A61ANTIOSTEOPOROSISA61COMPREHENSIVEEVALUATIONA62A63A64A65A66A165A67A167A68A69A70A71A72A73A74A75A76A164A77A66A78A79A79A80A81A79A82A80A79A78A79A79A83A84A86A87A88A89A90A91A92A93A94A95A96A97A98A99A101A102A103A104A105A106A107A108A109A110A59A107A108A111A112A113A58006100330558A60A114A116A117A84A119A120A121A122A123A124A102A125A127A128A129A130A131A132A133A134A135A127A128A129A127A136A137189A138512DA139A140A141A142A143A144A145A148A149A150A151A144A152A153A154A155A132A156A157A159A160A161A162A163A166A139A168A169A170A171A172A173A174A175A176A177A132A178A179A180A181A182A183A184A185A148A186A142A187A188A189A190A151A144A139A191A192A193A194A176A132A195A196A197A198A132A197A199A200A201A202A203A130A204A205A139A206A181A207A208A209A183A184A186A210A211A212A198A150A213A206A181A207A214A215A216A217A210A218A132A219A208A209A162A148A130A131A197A198A153A220A221A222A223A224A225A226A227A228A132A229A219A208A209A162A148A130A131A197A198A230A231A153A232A233A234A155A226A235A228A139A236A237A161A238A131A206A181A239A240A241A242A153A243A156A244A154A155A132A137A232A245A192A246A247A161A248A249A132A250A161A162A163A166A153A251A252A132A135A133A253A254A148A162A129A148A255A145A144A148A147A0A144A148A206A181A222A223A10A1A2A3A4A5A6A156A139A7A8A9A11A12A13A9A11A12A13A7A14A7A15A16ELX800A90A17A18A19A160A20A21A22LEICAA161A23A24A25A18A19A164A20A21A26NAPCOCO2A165A27A28A19A160A20A21A26LCMS8000AA82A64A29A30A31A32A33A171A70A33A34A35A18A26A173A36A19A175A37A21A22UV3101PCA176A38A178A39A180A40A38A41A42A24A43A43A44A45A26A173A36A19A175A37A21A26MILLIQA10A19A186A46A47A48A49MILLIPOREINCA50A51A52A53A50A186A54A55A56A47A57A58A49A194A59A60A61A159A48A62A53A50LX20A146A197A63A65A66A67A68A159A50BECKMANCOULTERA49A51A52A53A50SN695AA69A71A72A73A74A75A76A77A203A78A159A50A194A59A79A80A72A81A83A84A85A86A159A48A62A5055P72A87A88A89A91A92A93A94A95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