翼状胬肉发病机制的探讨课件

,翼状胬肉发病机制的探讨 （Research on pathogenesis of the pterygium） 2014级研究生 白梦天,1.what is pterygium？,Keyword: A.tropical ; sand blown by the wind; sexuality B.incidence of a disease (approximately 37.46%) C.complicated and intractable ( Pathogenesy is indefinite;recurrence 20%-30%),1.what is pterygium？,2. clinical manifestion and diagnosis,(1)clinical manifestion: no subjective symptom or feel foreign body sensation slightly. astigmatism,vision loss,Eye movement disorder (2)diagnosis: Under the slit lamp,we can see fibrous and vessel tissue invade into cornea,3.Pathogenesy of the pterygium There are series of hypothesis to expain it. (1)theory of the limbal stem cells(LSCs) (2)theory of the proliferation and apoptosis (3)theory of the MMP (4)theory of theoxidative stress,3.1 theory of the limbal stem cells(LSCs),Limbal stem cells could maintain homeostasis and repair impairment of the corneal epithelium,it has ability of high proliferation.,limbal stem cells encounter functional deficit,conjunctival epithelium invade into corneal epithelium,new vessels encroach corneal epithelium,pterygium,3.2(1)anti-apoptosis,promote apoptosis gene: bad bak bax repress apoptosis gene: bcl-2 bax + bcl-2,3.2(2) P53,(1)immunohistochemistry (2)DNA sequencing,3.3 theory of the MMP,zymogen,Ca2+ Zn2+,MMP-2,MMP-9,PKase signal transduction,facilitate new vessels,facilitate fibrocyte,pterygium,3.4 theory of oxidative stress,(1) 8-ohdg could induce oxidative stress,it has High expression in the patient of the