cancer胃癌课件

Gastric cancer,Whats cancer？,normal cells Vs. abnormal cells,Gastric cancer,4th most common cancer, 930,000 cases/year,2nd most common cause of cancer death,Geographic variations,Geographic distribution of mortality rates for gastric cancer in males in China,Here comes a patient,Examining room in USA,Clinical manifestation,Signs and Symptoms Early Gastric Cancer Asymptomatic or silent 80% Peptic ulcer symptoms 10% Nausea or vomiting 8% Anorexia 8% Early satiety 5% Abdominal pain 2% Gastrointestinal blood loss 2% Weight loss 2% Dysphagia 1%,Signs and Symptoms,Advanced Gastric Cancer Weight loss 60% Abdominal pain 50% Nausea or vomiting 30% Anorexia 30% Dysphagia 25% Gastrointestinal blood loss 20% Early satiety 20% Peptic ulcer symptoms 20% Abdominal mass or fullness 5% Asymptomatic or silent 5%,Duration of symptoms Less than 3 month 40% 3-12 months 40% Longer than 12 month 20%,Diagnosis,Endoscopic image,leather bottle-like,Endoscopic images,Histopathology,Poor to moderately differentiated adenocarcinoma of the stomach,Gastric signet ring cell carcinoma,Histopathology,Pathohistologic classification,Histology Adenocarcinoma 90% Lymphoma 5% Stromal 2% Carcinoid 1% Metastasis 1% Adenosquamous/squamous 1% Miscellaneous 1%,Radiologic diagnosis,Distal GC,Proximal GC,Linitis plastica,CT scan,Treatment,Surgical resection,EMR,Adjuvant therapy,Palliative therapy,Endoscopic mucosal resection,Gastric cancer lesion confined to mucosa layer,Endoscopic ultrasound (EUS) is helpful in stageing GC,Early stage GC-EMR,Open Surgery,Remove the lymph nodes,Laparoscopic Surgery,Dr. Robot,Treatment,Surgical resection,EMR,Adjuvant therapy,Palliative therapy,AIM OF COMBINATION THERAPY,INCREASED EFFICACY,Different mechanisms of action Compatible