溃疡性结肠炎活动性及疗效判断MS-AUCA.pdf

溃疡性结肠炎活动性及疗效判断标准溃疡性结肠炎活动性及疗效判断标准 溃疡性结肠炎 UC 临床疗效评判有很多标准 现推荐一个刊登于新英格兰杂志的疗 效评价指标体系 新英格兰杂志是临床医学论文的标杆杂志 引用该杂志的论文标准更容易 与国际接轨 在国内的杂志上尚未发现有引用该标准的 故在此整理推荐使用 它依据 4 项指标 包括大便次数 便血 内镜检查和医生整体评估 先对患者活动性做一个评价 是一个综合评分体系 然后依据治疗后评分的改变来做临床效应评估 评估结果分为有效和 无效 非常有利于临床效应的统计分析 1 Mayo 溃疡性结肠炎活动性评分系统溃疡性结肠炎活动性评分系统 Mayo Scoring System for Assessment of Ulcerative Colitis Activity Stool frequencyStool frequency 大便频数 大便频数 0 Normal no of stools for this patient 1 1 to 2 stools more than normal 2 3 to 4 stools more than normal 3 5 or more stools more than normal Subscore 0 to 3 Rectal bleedingRectal bleeding 便血 便血 0 No blood seen 1 Streaks of blood with stool less than half the time 2 Obvious blood with stool most of the time 3 Blood alone passes Subscore 0 to 3 Findings on endoscopy 内镜下发现 Findings on endoscopy 内镜下发现 0 Normal or inactive disease 1 Mild disease erythema decreased vascular pattern mild friability 2 Moderate disease marked erythema lack of vascular pattern friability erosions 3 Severe disease spontaneous bleeding ulceration Subscore 0 to 3 PhysicianPhysician s global assessments global assessment 医生整体评估 医生整体评估 0 Normal 1 Mild disease 2 Moderate disease 3 Severe disease Subscore 0 to 3 The Mayo score ranges from 0 to 12 with higher scores indicating more severe disease Data are from Schroeder et al Each patient serves as his or her own control to establish the degree of abnormality of the stool frequency The daily bleeding score represents the most severe bleeding of the day The physician s global assessment acknowledges the three other criteria the patient s daily recollection of abdominal discomfort and general sense of well being and other observations such as physical findings and the patient s performance status Reference Kenneth W Schroeder M D Ph D William J etal Coated Oral 5 Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis N Engl J Med 1987 317 1625 1629December 24 1987 2 UC 临床效应判断临床效应判断 A response was defined as a decrease in the Mayo score of at least 3 points and at least 30 percent with an accompanying decrease in the subscore for rectal bleeding of at least 1 point or an absolute rectal bleeding subscore of 0 or 1 临床效应定义 Mayo Score 降低 3 点 且降低超过 30 同时便血降低 1 点或便血的 分值为 0 或 1 Reference Paul Rutgeerts M D Ph D William J Sandborn M D etal