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CellSignalTransduction JunlingLiu SchoolofMedicineShanghaiJiaoTongUniversity2015 4 29 Whatiscellsignaltransduction Smallcelllungcarcinoma Osteoporosis CAD Cellcommunicationandsignaltransduction MolecularPathophysiology Insulinfunctions BasicProfilesofCellSignalTransduction Theresponseofaparticularcelltoasignaldependsonthetypeofproteinsitcontains Signal Receptor Signaltransductionpathway Geneexpression Profileofasignalingcomponent Signalingmoleculesoperateovervariousdistancesinanimals Sevenmajorclassesofmembranereceptors CytoskeletalRearrangement Changesingeneexpression CellCycleArrest EffectorProtein CellResponsetotheSignal EffectorProteins Protein ProteinInteraction Proteinphosphorylation ProteinUbiquitination Proteinsumoylation Proteinacetylation Proteinpost translationmodification DynamicandReverse Classicalcellsignalingpathway Example1 Integrin IIb 3MediatesDual directionsSignalingTransductionandPlateletActivation Aggregation Spreading ClotsRetraction Integrin IIb 3 MediatedSignalingandHemostasis Anti plateletdrugs NigelMackman Nature2008 451 21 914 918 PercutaneousCoronaryIntervention PCI TherapyofAcuteCoronarySyndromes ACS Example2 BiologyofPI3K Aktsignalingpathway GerritvanMeer DennisR Voelker GeraldW Feigenson Membranelipids wheretheyareandhowtheybehave NatureReviewsMolecularCellBiology9 112 24 mammalsyeast Signalinglipids 1 totalphospholipidPIP2inplasmamembrane PI PIP PIP2 5 5 05 109phospholipidsinplasmamembrane Lipidcompositionvariesamongcellmembranes Lipidhydrolysis NatureReviewsDrugDiscovery8 627 644 August2009 LiuPetal ImportantroleofPI3K Aktsignalingpathway NatureReviewsDrugDiscovery8 627 644 August2009 LiuPetal PI3Kfamily Newton A C J LipidRes 2009 50 S266 S271 ProteinkinaseB Akt ReceptorsmediatedAktactivationandits functions BasicregulatorsofPI3K Aktsignalingpathway PTEN MMAC1 mutatedinmultipleadvancedcancers1 PI3 kinaseisopposedbylipidphosphatasePTEN mTORfunctionsintwodistinctcomplexesandpathways PI3KSignalingInhibitorsTested PI3KSignalingInhibitorsTestedforCancerChemotherapy InsulinmediatedPI3KSignalingandDiabetes PlateletsGPVImediatedPI3K AktSignalingandArthritis PlateletadhesivereceptorGPVImediatedsignaling PROTEOMICS AnnualReviewofGenomicsandHumanGenetics Vol 5 267 293 2004 LargeScaleInvestigationofCellSignaling GENOMICS MetabonomicNetwork CellDesignerisastructureddiagrameditorfordrawinggene regulatoryandbiochemicalnetworks Intuitiveuser interfacehelpsyoutodrawadiagraminrichgraphicalrepresentationwithyourowndesign CellDesigner Version4 1http celldesigner org features htmlfreedownload SNAVI DesktopApplicationforAnalysisandVisualizationofLarge ScaleCellSignalingNetworks Softwares Usefulwebsite ProfessorSirMichaelBerridge FRS http www biochemj org csb default htm Afantasticresourceforeducatorsandresearchersalike andforanyoneinterestedinthebasicsanddetailsofcellsignallingpathways Thediagramsareparticularlyusefulasteachingtools Ihighlyrecommendthistoanyoneengagedinsignallingresearch AlexToker HarvardMedicalSchool Boston Contents1Introduction2Cellsignallingpathways3Ionchannels4Sensorsandeffectors5Offmechanisms6Spatialandtemporalaspectsofsignalling7Cellularprocesses8Development9Cellcycleandproliferation10Neuronalsignalling11Cellstress inflammatoryresponsesandcelldeath12Signallingdefectsanddisease CellSignallingBiology Howtostudy MAPKsignaling Smadsignaling CellSignallingBiology MichaelJ Berridge www cellsignallingbiology org 2009 Wntsignalingpathways CellSignallingBiology MichaelJ Berridge www cellsignallingbiology org 2009 Stimuliforenzyme linked