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Meeting you was fate, and falling in love with you was out of my control.遇见你是命运的安排而爱上你是我情不自禁。In this world there are only two tragedies. One is not getting what one wants, and the other is getting it.在这个世界上只有两种悲剧:一种是得不到自己想要的东西,另一种是得到了。In this world there are only two tragedies. One is not getting what one wants, and the other is getting it.Life is an onion and one cries while peeling it.Life is an onion and one cries while peeling it.Life is an onion and one cries while peeling it. 生命就是一个洋葱,我们泪汪汪的,一层层剥开它。If a jewel falls into the mire, it remains as precious as before; and though dust should ascend to heaven, its former worthlessness will not be altered.宝石即使落在泥潭里,仍是一样可贵;尘土纵然扬到天上,还是没有价值。If a jewel falls into the mire, it remains as precious as before; and though dust should ascend to heaven, its former worthlessness will not be altered.When your heart breaks, your whole body hurts心碎了,你的整个身体也会受伤When your heart breaks, your whole body hurts.When your heart breaks, your whole body hurts.Even if you get no applause, you should accept a curtain call gracefully and appreciate your own efforts. Even if you get no applause, you should accept a curtain call gracefully and appreciate your own efforts.即使没有人为你鼓掌,也要优雅的谢幕,感谢自己的认真付出。The value of life lies not in the length of days, but in the use we make of them.The value of life lies not in the length of days, but in the use we make of them.生命的价值不在于能活多少天,而在于我们如何使用这些日子。p73 is a p53-related transcription factor with fundamental roles in p73 is a p53-related transcription factor whit fundamental roles in development and tumor suppression. The transcription from two different promoters on the p73 gene results in generation of transcriptionally active Tap73 isoforms and dominant negative p73 isoforms with opposing pro and anti-apoptotic functions. Therefore , the relative ratio of each isoform is an important determinant of the cell fate. Proteasomal degradation of p73development and tumor suppression. Transcription from two different promoters on the p73 gene results in generation of transcriptionally active TAp73 isoforms and dominant negative tNp73 isoforms with opposing proand anti-apoptotic functions. Therefore. the relative ratio of each isoform is an important determinant of the cell fate. Proteasomal degradation of p73 is mediated by polyubiquitination-dependent and -independent processes both of which appear, thus far, to lack selectivity for the TAp73 and ANp73 isoforms. Here, we describe the characterization of another transcriptional target of TAp73; a ring finger domain ubiquitin Iigase p73 Induced RING 2 protein (PIR2). Although PIR2 was initially identified a p53-induced gene (p53RFP). low abundance of PIR2 transcript in mouse embryonic fibroblasts of TAp73 KO mice compared with WT mice and comparison of PIR2 mRNA and protein levels following TAp73 or p53 overexpression substantiate TAp73 isoforms as strong inducers of PIR2. Although PIR2 expression was induced by DNA damage, its expression did not alter apoptotic response or cell cycle profile per Se. However. coexpression of PIR2 with TAp73 or Np73 resulted in an increase of the TA/Np73 ratio. due to preferential degradation of Np73. Finally, PIR2 was able to relieve the inhibitory effect of ANp73 on TAp73 induced apoptosis following DNA damage. These results suggest that PIR2. by being induced by TAp73 and degrading Np73, differentially regulates TAp73htNp73 stability, and, hence, it may offer a therapeutic approach to enhance the chemosensitivity of tumor cells. ABSTRACT FROM AUTHORTrust is like a piece of paper. When it creases, it cannot recover even it is smoothed.信任就像一张纸,皱了,即使抚平,也恢复不了原样了。Trust is like a piece of paper. When it creases, it cannot recover even it is smoothed.Trust is like a piece of peper. When it creases, it cannot recover even it is smoothed.Trust is like a piece of paper. When it creases, it cannot recover even it is smoothed.Trust is like a piece of paper. When it creases, it cannot recover even it is smoothed.We do not need magic to transform our world. We carry all of the power we need inside ourselves already.-J. K. Rowling改变世界不需要魔法,只要我们发挥出内在的力量。JK罗琳We do not need magic to transform our word. We carry all of the power we need inside ourselves already.We do not need magic to transform our word. We carry all of the power we need inside ourselves already.We do not need magic to transform our word, we carry all of the power we need inside ourselves already.The key for happiness is not to find a perfect person, but find someone and build a perfect relationship with him.幸福的关键不在与找到一个完美的人,而在找到一个人,然后和他一起努力建立一个完美的关系。The key for happiness is not to find a perfect person, but find someone and build a perfect relationship with him.Its never too late to be the person you want to be.成为自己想成为的人,永远不会太迟。It is never too late to be the person you want to be.It is never too late to be the person you want to be.It is never too late to be the person you want to be.It is never too late to be the person you want to be.It is never too late to be the person you want to be.Everyones got a life that no one else knows about.各自人生,冷暖自知。Everyone is got a life that no one else knows about.Everyones got a life that no one else knows about.Everyones got a life that no one else knows about.Everyones got a life that no one else knows about.Everyones got a life that no one else knows about.Love is composed of a single soul inhabiting two bodies.爱是栖息在两个躯体里的一个灵魂。Love is composed of a single soul inhabiting two bodies.Love is composed of a sin
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