Alogliptin-Benzoate-SYR-322-DataSheet-MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAlogliptin BenzoateCat. No.: HY-A0023CAS No.: 850649-62-6Synonyms: SYR 322分式: CHNO分量: 461.51作靶点: Dipeptidyl Peptidase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 D

2、MSO : 50 mg/mL (108.34 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1668 mL 10.8340 mL 21.6680 mL5 mM 0.4334 mL 2.1668 mL 4.3336 mL10 mM 0.2167 mL 1.0834 mL 2.1668 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体

3、内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.42 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.42 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1

4、/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.42 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Alogliptin benzoate(SYR 322)活性DPP-4抑制剂，IC5010 nM，对DPP-8和DPP-9的抑制性10000倍。户使本产品发表的科研献 Biochem Biophys Res Commun. 2019 Apr 2;511(2):387-393. Chromatography. 2015,36(1):19-24.See more c

5、ustomer validations on HYPERLINK / www.MedChemEREFERENCES1. Rendell M, et al. Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2012 Mar;13(4):553-63.2. Radha Andukuri, et al. Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes Metab Syndr Obes. 20

6、09; 2: 117-126.3. Takeuchi K, et al. Pharmacological and clinical profile of alogliptin benzoate (NESINA?).Nihon Yakurigaku Zasshi. 2011 Jan;137(1):43-50.4. Moritoh Y, et al. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improvesglycemic control and beta-cell function in obese diabetic ob/ob mice.Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te