Endoxifen-E-isomer-E-Endoxifen-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEndoxifen E-isomerCat. No.: HY-18719DCAS No.: 114828-90-9Synonyms: E-Endoxifen分式: CHNO分量: 373.49作靶点: Estrogen Receptor/ERR作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 32 mg/mL

2、 (85.68 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6774 mL 13.3872 mL 26.7745 mL5 mM 0.5355 mL 2.6774 mL 5.3549 mL10 mM 0.2677 mL 1.3387 mL 2.6774 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Endoxifen E-isomer(Z)-Endoxifen

3、 的 E-异构体。(Z)-Endoxifen 通过 CYP3A4/5 和 CYP2D6 作产的活性代谢物， 种选择性雌激素受体调节剂 (SERM)。体外研究Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumedthat (E)-Endoxifen, structurally related to (E)-4-OH-tamoxifen, have similar pharmacological properties. The1/2 Mast

4、er of Small Molecules 您边的抑制剂师www.MedChemE(E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions.(E)-Endoxifen is identified as the primary degradant 1.REFERENCES1. Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z)-Endoxifen by 2D NMR, high resolution LC-MS, andquantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>