Zardaverine - Phosphodiesterase (PDE) 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZardaverineCat. No.: HY-15485CAS No.: 101975-10-4分式: CHFNO分量: 268.22作靶点: Phosphodiesterase (PDE)作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 28 mg/mL (104.3

2、9 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.7283 mL 18.6414 mL 37.2828 mL5 mM 0.7457 mL 3.7283 mL 7.4566 mL10 mM 0.3728 mL 1.8641 mL 3.7283 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Zardaverine是新型的PDE3和4抑制剂，IC50分别为0.5 u

3、M和0.8 uM。REFERENCES1. R.T. Schermuly, H. Leuchte, H.A. Ghofrani, et al. Zardaverine and aerosolised iloprost in a model of acute respiratoryfailure. ERJ, 2003,22 (2): 342-347.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. D. Ukena, K. Rentz, C. Reiber, et al. Effects of the mixed phosphodiester

4、ase III/IV inhibitor, zardaverine, on airway function in patientswith chronic airflow obstruction. Respiratory Medicine.1995, 89 ( 6) : 441-444.3. Schade FU, Schudt C. The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosisfactor by macrophages. European Journal of Pharmacology.1993, 230(1):9-14.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa