Ferroptosis-IN-8-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEFerroptosis-IN-8Cat.No.:HY-163654分子式: C₁₅H₁₅N₃O₃分子量: 285.3作用靶点: Ferroptosis作用通路: Apoptosis储存方式: PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Ferroptosis-IN-8(化合物B4)是一种铁死亡抑制剂，IC50值为40.49nM。Ferroptosis-IN-8通过其固有的抗氧化能力来抑制RSL3(HY-100218A)或FIN56(HY-103087)诱导的铁死亡，显著减轻肝肾损伤，有望用于预防铁死亡相关疾病[1]。IC50&TargetIC50:40.49nM(Ferroptosis)体外研究Ferroptosis-IN-8(CompoundB4)(200nM)effectivelyrescuesHKC,HK-2,Khos,SW480,andHTR-8/SVneocellsfromferroptosisinducedbyRSL3orFIN56[1].Ferroptosis-IN-8(CompoundB4)(200nM)againstesferroptosispredominantlyreliesontheirintrinsicantioxidativecapacity,ratherthanclassicalsignalingpathwaysincludinglipidoxidationmetabolism[1].CellViabilityAssay[1]CellLine:HKC,HK-2,HT-1080,Khos,SW480,andHTR-8/SVneocellstreatmentwithRSL3orFIN56Concentration:200nMIncubationTime:24hResult:EffectivelyrescuedHKC,HK-2,HT-1080,Khos,SW480,andHTR-8/SVneocellsfromferroptosisinducedbyRSL3orFIN56.RealTimeqPCR[1]1/3 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECellLine:HT-1080cellConcentration:200nMIncubationTime:Result:Didn'tsignificantlyaffecttheproteinlevelsofkeyfactorsrelatedtolipidmetabolism(ACSL4,ALOX15,andCOX2),glutathionemetabolismpathways(GPX4,SLC7A11),andironmetabolism(DMT1,TFRC,andFTH1)体内研究Ferroptosis-IN-8(CompoundB4)(10mg/kg,twice,1hbeforeischemiaonset,i.p.)alleviatestissuedamageinamousemodelofrenalischemia-reperfusioninjury[1].Ferroptosis-IN-8(CompoundB4)(10mg/kg,i.p.)alleviatesacetaminopheninducedacuteliverinjuryinmicebyinhibitingferritin[1].AnimalModel:acetaminophen-inducedacuteliverinjurymicemodel[1].Dosage:10mg/kgAdministration:intraperitonealinjection(i.p.)Result:AttenuatedtheincreasedplasmaALTandASTlevelsinducedbyacetaminophen,effectivelyreducedtheinjuryresponseinducedbyacetaminophen[1].AnimalModel:kidneyischemia−reperfusioninjurymicemodel[1].Dosage:10mg/kg,twice,1hbeforeischemiaonset.Administration:intraperitonealinjection(i.p.)Result:ReducedthelevelsofcreatinineandBUNandalleviatedtheincreaseinKIM-1levelsintheI/Rmodel[1].AnimalModel:Dosage:Administration:Result:AnimalModel:Dosage:Administration:2/3 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEResult:REFERENCESShengxiehua,etal.DiscoveryofNovelOrtho-AminophenolDerivativesTargetingLipidPeroxidationwithPotentAntiferroptoticActivitie.J.Med.Chem.2024;67:9536−9551.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplicat