厌氧性细菌(人卫7版微生物).ppt

1、Chapter 13无氧细菌，概述，生长和代谢，不需要氧气，通过发酵获得能量，能否形成豆芽，无氧孢子无氧细菌，第一节无氧孢子(cte Tata Ubiquitous in soil，it is occasionally found in intestinal flora of humans and animals . causes tetanus(破伤风)or lockjaw，) gram()；Swarming occurs on blood agar，Faint hemolysis。薄膜型爬行动物生长生物化学反应activities : does not ferment any carboh

2、ydrate and proteins resistance Tolerate Boiling for 660Alive Severalten Years in soil，Pathogenesis，发病条件，伤口要湿氧微环境伤口窄，深(如刺伤)，土壤或异物污染，大面积创伤，烫伤局部缺血，是氧菌或兼性盐酸盐混合感染，对于脊髓前角和脑干神经细胞，高亲和力为蛋白质，无耐热性，蛋白酶破坏，酪氨酸酶，破伤风痉挛毒素作用机制，Lightchain，-S-S-，Cleave，heavNeonatal tetanus，Diagnosis，Diagnosis is primarily by the clinic

3、al manifestations(临床表现)。the wound may not be obvious . c . tetani can be recovered from the wound in only about one-third of the cases . it is important for the Aware that toxigent、immunity、Humoral immunity(antitox in)there is little、if any、Innate immunity and the disease does not produce immunity特异

4、性预防：白癜风三联疫苗，受伤后立即破伤风抗毒素(tetanus antitoxin，TAT)特异性治疗：发病者，早期抗毒素和抗生素，2，产气荚膜梭菌，BIOLS Structure:large gram-PPSCapsulated，hemolytic and metabolic ally active Stormy fermentation，culture，厌氧，最佳生长温度42 Biochemical activities，产气荚膜梭菌到蛋黄一千版，根据猛烈发酵、打字、4茄子主要毒素(，)的生产，对人致病的主要原因是a型，virulence factors，virulence factors

5、 toxins alpha toxin causes RBC rupture， leucocytes and endothelial cells increased vascular permeability with massive hemo lysis and bleeding tissue destruction hepatic toxicity and my As superantigen。鼠疫、气坏疽(Gas Gangrene)发病条件与破伤风梭菌相似，肺气肿、水肿、组织坏死、水气混合，感到心悸，食物中毒(food poisoning)是腹泻、空气坏疽、lab digan osis、

6、treatment and prevention、immediate cleansing of dirty wounds、deep wounds、decubitus ulcers、compound fractures、and分型：根据神经毒素的抗原性，有7个A-G型，我国大部分是A型。抵抗力：肉毒毒素不耐热，煮一分钟就破坏。幼苗耐热性，100 3-5h，生物特征，anaerobic gram-positive rod-shaped spore former produces a protein neuro toxic，decaaintestinal tracts of birds，mammals and fish。肉毒杆菌纯培养的镜子形态(革兰氏染色)、致死物质、肉毒杆菌、病机致病性、发病机制、牙齿毒素通过肠道吸收血液，作用于脑神经核和外周神经肌肉连接部及自主神经末梢，妨碍乙酰胆碱释放，引起运动神经末梢功能障碍，引起松弛性麻痹。，肌纤维，神经根连接，突触前膜，突触后膜，肉毒杆菌作用机制，正常，阻断，这是面部肌肉解剖图。由于面部表情肌肉复杂，每根针注射的位置和剂量是去除褶皱的关键。botulism transmission、home-canned goods(food borne)particular ly low-acid foods such as as