L-Epinephrine-Bitartrate-minus-Epinephrine-plus-bitartrate-salt-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-Epinephrine BitartrateCat. No.: HY-B0447ACAS No.: 51-42-3Synonyms: (-)-Epinephrine (+)-bitartrate salt; L-Adrenaline (+)-bitartratesalt分式: CHNO分量: 333.29作靶点: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: 4C, p

2、rotect from light, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight, stored under nitrogen)溶解性数据体外实验 H2O : 100 mg/mL (300.04 mM; adjust pH to 2 with HCl)H2O : 50 mg/mL (150.02 mM)DMSO : 50 mg/mL (150.02 mM; Need ultrasonic)* means soluble, but saturation unknown.M

3、ass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0004 mL 15.0019 mL 30.0039 mL5 mM 0.6001 mL 3.0004 mL 6.0008 mL10 mM 0.3000 mL 1.5002 mL 3.0004 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的

4、百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.50 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.50 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn

5、 oilSolubility: 2.5 mg/mL (7.50 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 L-Epinephrine bitartrate (-)-Epinephrine (+)-bitartrate salt)是-adrenergic 和 -adrenergic 的激动剂。L-Epinephrine bitartrate (-)-Epinephrine (+)-bitartrate salt)是由肾上腺髓质分泌的激素。体内研究 A 25 microliter volume of a 1-% L-epinephrine borate s

6、olution applied on the cornea of one eye in 12monkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared tothe untreated control eyes 1. Epinephrine is a direct-acting sympathomimetic -adrenergic and -adrenergicagonist with cyclic adenosine monophosphate-

7、mediated, complex, bidirectional pharmacologic effects onmany target organs 2. In young adult rats, endogenous release of epinephrine facilitates stable memoryformation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, byincreasing blood glucose levels neede

8、d to modulate memory 3. Epinephrine is the primary drugadministered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increasesarterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects 4.户使本产品发表的科研献 Int J Clin Exp Med. 2019;12(

9、2):1640-1648.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980May;19(5):487-91.2. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epi

10、nephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.3. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-relatedmemory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.4. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.McePdfHeightCaution: Product has not been fully va