Baclofen-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEBaclofen(Standard)Cat.No.:HY-B0007RCASNo.:1134-47-0分子式:C₁₀H₁₂ClNO₂分子量:213.66作用靶点:GABAReceptor作用通路:MembraneTransporter/IonChannel;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验0.1MHCL:10mg/mL(46.80mM;Needultrasonic)DMSO:4.81mg/mL(22.51mM;ultrasonicandwarmingandadjustpHto4withHClandheatto60°C)H2O:2mg/mL(9.36mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.6803mL23.4017mL46.8033mL5mM0.9361mL4.6803mL9.3607mL10mM0.4680mL2.3402mL4.6803mLBIOLOGICALACTIVITY生物活性Baclofen(Standard)是Baclofen的分析标准品。本产品用于研究及分析应用。Baclofen是γ-氨基丁酸(GABA)的亲脂性衍生物，是一种口服有效，选择性的代谢型GABAB受体(GABABR)激动剂。Baclofen可以模拟GABA的作用并通过GABAB受体产生缓慢的突触前抑制。Baclofen具有高的血脑屏障透过率。Baclofen有用于肌肉痉挛研究的潜力。REFERENCES[1].Bexis,S.,etal.,BaclofenpreventsMDMA-inducedriseincorebodytemperatureinrats.DrugAlcoholDepend,2004.74(1):p.89-96.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEMehdiFarokhnia,etal.AdeeperinsightintohowGABA-Breceptoragonismviabaclofenmayaffectalcoholseekingandconsumption:lessonslearnedfromahumanlaboratoryinvestigation.MolPsychiatry.2018Oct31.WooriKim,etal.Baclofen,aGABABreceptoragonist,enhancesubiquitin-proteasomesystemfunctioningandneuronalsurvivalinHuntington'sdiseasemodelmice.BiochemBiophysResCommun.2014Jan10;443(2):706-11.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559