HHQ16-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEHHQ16Cat.No.:HY-160706CASNo.:2620471-66-9分子式:C₃₀H₄₈F₂O₄分子量:510.7作用靶点:Others作用通路:Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性HHQ16是黄芪甲苷IV(HY-N0431)的口服活性衍生物。HHQ16通过靶向降解lnc4012/lnc9456、拮抗其对G3BP2/NF-κB信号传导的影响，来有效逆转梗塞引起的肥大和心力衰。体外研究HHQ16(100nM,6h)bindstolnc9456withhigh-affinityandinducesitsdegradationinHL-1mousecardiomyocytes[1].体内研究HHQ16(1-100mg/kg,oralgavage,dailyfor4weeks)effectivelyreversestheleftanteriordescendingcoronaryarteryligation(LADL)-induceddeteriorationofcardiacfunctionandstructuralremodelinginmice[1].HHQ16(10mg/kg,p.o.,2weeks)decreasesthehighleveloflnc9456intheheartandregresstheremodelingassociatedchangesinAAV-lnc9456mice[1].AnimalModel:leftanteriordescendingcoronaryarteryligation(LADL)-inducedheartfailuremice[1]Dosage:1-100mg/kgAdministration:oralgavage,dailyfor4weeksResult:Increasedtheeftventricularejectionfraction(LVEF)andleftventricularfractionalshortening(LVFS)ofthemice.Reducedtheenlargedheartsizeandtheheartweighttobodysurfacearearatio(HW/BSA).ReversedLADL-inducedhypertrophybydecreasingthecellvolume(size)andslippage1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemE(disorderlyalignedmyocytes).ReversedLADL-inducedincreaseinANP,BNP,β-MHC,andhypertrophicexpressionofANPandBNP.REFERENCESWanJ,etal.AstragalosideIVderivativeHHQ16amelioratesinfarction-inducedhypertrophyandheartfailurethroughdegradationoflncRNA4012/9456.SignalTransductTargetTher.2023Oct19;8(1):414.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;