I-BOP-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEI-BOPCat.No.:HY-116431CASNo.:128719-90-4分子式:C₂₃H₂₉IO₅分子量:512.38作用靶点:ProstaglandinReceptor作用通路:GPCR/GProtein储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性I-BOP是血栓素A2受体(TP)的激动剂，KD为0.61nM。I-BOP通过激活血管平滑肌中的PI3K通路来促进细胞增殖[1]。I-BOP剂量依赖性的双相影响海马神经元中的兴奋性突触后电位(e.p.s.p.)[2]。体外研究I-BOP(1-100nM)activatestheMAPkinase,stimulatesthetyrosinephosphorylation,andthuscausestheactivationofPI3Ksignalingpathway[1].I-BOP(0.1-3μM)enhancesthesynaptictransmissioninhippocampalCA1neuronatlowconcentrationbyincreasingtheneurotransmitterrelease,inhibitstheexcitatorysynaptictransmissioninhippocampalCA1neuronthroughreductionofmembraneinputresistanceathighconcentration[2].WesternBlotAnalysis[1]CellLine:A7r5.HEL.TPcellConcentration:1-100nMIncubationTime:24hResult:Increasedphosphorylatedtyrosine.REFERENCESMorinelliTA,etal.,Tyrosinephosphorylationofphosphatidylinositol3-kinaseandofthethromboxaneA2(TXA2)receptorbytheTXA2mimeticI-BOPinA7r5cells.BiochemPharmacol.1997Jun15;53(12):1823-32.HsuKS,etal.,ThromboxaneA2agonistmodulationofexcitatorysynaptictransmissionintherathippocampalslice.BrJPharmacol.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemE1996Aug;118(8):2220-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fa