Ibutilide-fumarate-Standard-U70226E-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEIbutilidefumarate(Standard)Cat.No.:HY-B0387RCASNo.:122647-32-9Synonyms:U70226E(Standard)分子式:C₂₄H₄₀N₂O₇S分子量:442.61作用靶点:PotassiumChannel作用通路:MembraneTransporter/IonChannel储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:≥50mg/mL(112.97mM)H2O:50mg/mL(112.97mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2593mL11.2966mL22.5933mL5mM0.4519mL2.2593mL4.5187mL10mM0.2259mL1.1297mL2.2593mLBIOLOGICALACTIVITY生物活性Ibutilide(fumarate)(Standard)是Ibutilide(fumarate)的分析标准品。本产品用于研究及分析应用。Ibutilide(U70226E)fumarate是一种延长动作电位的抗心律失常剂，作用于AT-1细胞，可有效阻断快激活延迟整流钾电流(IKr)。REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEIbutilide,amethanesulfonanilideantiarrhythmic,isapotentblockeroftherapidlyactivatingdelayedrectifierK+current(IKr)inAT-1cells.Concentration-,time-,voltage-,anduse-dependenteffects.Circulation.1995Mar15;91(6):1799-806.BFMcBride,etal.InfluenceoftheG2677T/C3435ThaplotypeofMDR1onP-glycoproteintraffickingandIbutilide-inducedblockofHERG.PharmacogenomicsJ.2009Jun;9(3):194-201.SSChugh,etal.AlteredresponsetoIbutilideinaheartfailuremodel.CardiovascRes.2001Jan;49(1):94-102.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: