IL17A-IN-1-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEIL17A-IN-1Cat.No.:HY-158159分子式:C₃₀H₃₅Cl₂N₇O₃分子量:612.55作用靶点:InterleukinRelated作用通路:Immunology/Inflammation储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性IL17A-IN-1(化合物72)是一种口服有效的Interleukin17A抑制剂。IL17A-IN-1可用于炎症和自身免疫性疾病，如斑块状银屑病、银屑病关节炎和强直性脊柱炎等，以及癌症的研究。体外研究IL17A-IN-1inhibitsHelacellswithanIC50valueof0.005µM[1].体内研究IL17A-IN-1(10mg/kg;p.o.;singledose)inhibitsplasmaCXCL1secretioninhIL17A-inducedmouse(IL17receptor-containingmouse)CXCL1PDmodel[1].(SubcutaneousinjectionofrecombinanthumanIL17AintomiceinducesplasmaCXCL1secretion).AnimalModel:C57BL/6mice(hIL17A-inducedmouseCXCL1PDmodel)[1].Dosage:10mg/kgAdministration:Oraladministration;singledoseResult:Inhibited53%ofCXCL1secretioninhIL17A-inducedmouseCXCL1PDmodel.AnimalModel:MaleSprague-Dawleyrats;360-460g[1].Dosage:0.3mg/kgAdministration:Intravenousinjection;singledoseResult:1.19PharmacokineticParametersofIL17A-IN-1inmaleSprague-Dawleyrats[1].IV(0.3mg/kg)Vss(L/kg)5.0t1/2(h)3.6CLp/CLp,u(L/h/kg)1.1/6.11/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEREFERENCESRamosAL,etal.DiscoveryofSmallMoleculeInterleukin17AInhibitorswithNovelBindingModeandStoichiometry:OptimizationofDNA-EncodedChemicalLibraryHitstoInVivoActiveCompounds.JMedChem.2024Apr4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>