JJC8-088-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEJJC8-088Cat.No.:HY-158013CASNo.:1627576-82-2分子式:C₂₈H₃₂F₂N₂O₂S分子量:498.63作用靶点:DopamineTransporter作用通路:NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性JJC8-088是一种有效的DAT抑制剂。JJC8-088是一种新型的莫达非尼(Modafinil)衍生化合物。JJC8-088可用于研究精神兴奋剂使用障碍[1]。IC50&TargetDAT2.53nM(Ki)体内研究JJC8-088(3-30mg/kg,i.p.,30/120min)caneffectivelyreducethecompulsiveself-administrationofmethamphetamineinratsandincreasetheamountofexercise[1].JJC8-088(0-30mg/kg,i.p.,30minpriortotesting)cancausealargeandrapidincreaseinextracellularDopamine(DA)(HY-B0451)levelsinratswithhistoryofCocaineself-administration[2].AnimalModel:METHaddictmaleWistarrats(6-8weeksold;weighing200-250g)[1]Dosage:0/3/10/30mg/kgAdministration:i.p.Result:Thehalf-lifeofJJC8-088is39min.Presentedlowlevelsinbothbrainandplasma.REFERENCES[1].TunstallBJ,etal.Atypicaldopaminetransporterinhibitorsattenuatecompulsive-likemethamphetamineself-administrationinrats.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemENeuropharmacology.2018Mar15;131:96-103.NewmanAH,etal.Translatingtheatypicaldopamineuptakeinhibitorhypothesistowardtherapeuticsfortreatmentofpsychostimulantusedisorders.Neuropsychopharmacology.2019Jul;44(8):1435-1444.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792F