Olanzapine-Standard-LY170053-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEOlanzapine(Standard)Cat.No.:HY-14541RCASNo.:132539-06-1Synonyms:LY170053(Standard)分子式:C₁₇H₂₀N₄S分子量:312.43作用靶点:5-HTReceptor;DopamineReceptor;mAChR;AdrenergicReceptor;Autophagy;Mitophagy;Apoptosis作用通路:GPCR/GProtein;NeuronalSignaling;Autophagy;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:20mg/mL(64.01mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2007mL16.0036mL32.0072mL5mM0.6401mL3.2007mL6.4014mL10mM0.3201mL1.6004mL3.2007mLBIOLOGICALACTIVITY生物活性Olanzapine(Standard)是Olanzapine的分析标准品。本产品用于研究及分析应用。Olanzapine(LY170053)是一种选择性的、具有口服活性的单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂[1][2]。REFERENCES[1].APPROVEDAGREED-UPONLABELING.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEOlanzapineforInjection,powder,forsolutionforintramuscularuse.VucicevicL,etal.Autophagyinhibitionuncoverstheneurotoxicactionoftheantipsychoticdrugolanzapine.Autophagy.2014;10(12):2362-78.Karpel-MasslerG,etal.Olanzapineinhibitsproliferation,migrationandanchorage-independentgrowthinhumanglioblastomacelllinesandenhancestemozolomide'santiproliferativeeffect.JNeurooncol.2015Mar;122(1):21-33.CoccurelloR,etal.Chronicadministrationofolanzapineinducesmetabolicandfoodintakealterations:amousemodeloftheatypicalantipsychotic-associatedadverseeffects.Psychopharmacology(Berl).2006Jul;186(4):561-71.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021