Prazosin-hydrochloride-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPrazosinhydrochloride(Standard)Cat.No.:HY-B0193ARCASNo.:19237-84-4分子式:C₁₉H₂₂ClN₅O₄分子量:419.86作用靶点:AdrenergicReceptor;Autophagy作用通路:GPCR/GProtein;NeuronalSignaling;Autophagy储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:14.29mg/mL(34.04mM;Needultrasonic)H2O:0.59mg/mL(1.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3817mL11.9087mL23.8175mL5mM0.4763mL2.3817mL4.7635mL10mM0.2382mL1.1909mL2.3817mLBIOLOGICALACTIVITY生物活性 Prazosin(hydrochloride)(Standard)是Prazosin(hydrochloride)的分析标准品。本产品用于研究及分析应用Prazosinhydrochloride是一种耐受良好、具有CNS活性的α1-肾上腺素能受体(α1-adrenergicreceptor)拮抗剂。可用于研究高血压和酒精使用障碍[1]。Prazosinhydrochloride有效抑制去甲肾上腺素(NE)刺激的45Ca流出，IC50为0.15nM[2]。Prazosinhydrochloride抑制有机阳离子转运蛋白OCT-1和OCT-3，IC50分别为1.8和13μM[3]。REFERENCES[1].DennisDRasmussen,etal.Thealpha1-adrenergicreceptorantagonist,prazosin,reducesalcoholdrinkinginalcohol-preferring(P)rats.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEAlcoholClinExpRes.2009Feb;33(2):264-72.WSColucci,etal.Nonlinearrelationshipbetweenalpha1-adrenergicreceptoroccupancyandnorepinephrine-stimulatedcalciumfluxinculturedvascularsmoothmusclecells.MolPharmacol.1985May;27(5):517-24.DeborahLWhite,etal.OCT-1-mediatedinfluxisakeydeterminantoftheintracellularuptakeofimatinibbutnotnilotinib(AMN107):reducedOCT-1activityisthecauseoflowinvitrosensitivitytoimatinib.Blood.2006Jul15;108(2):697-704.JingZhang,etal.Prazosininhibitstheproliferation,migrationandinvasion,butpromotestheapoptosisofU251andU87cellsviathePI3K/AKT/mTORsignalingpathway.ExpTherMed.2020Aug;20(2):1145-1152.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-