Rivastigmine-tartrate-Standard-ENA-713-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemERivastigminetartrate(Standard)Cat.No.:HY-11017RCASNo.:129101-54-8Synonyms:ENA713(Standard);SDZ-ENA713(Standard)分子式:C₁₈H₂₈N₂O₈分子量:400.42作用靶点:Cholinesterase(ChE)作用通路:NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验H2O:50mg/mL(124.87mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4974mL12.4869mL24.9738mL5mM0.4995mL2.4974mL4.9948mL10mM0.2497mL1.2487mL2.4974mLBIOLOGICALACTIVITY生物活性Rivastigmine(tartrate)(Standard)是Rivastigmine(tartrate)的分析标准品。本产品用于研究及分析应用。Rivastigminetartrate(ENA713;SDZ-ENA713)是一种具有口服活性的，有效的胆碱酯酶(ChE)抑制剂，可抑制丁酰胆碱酯酶(BChE)和乙酰胆碱酯酶(AChE)，IC50分别为0.037μM和4.15μM。Rivastigminetartrate可透过血脑屏障(BBB)。Rivastigminetartrate是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。IC50&TargetIC50:0.037μM(BChE)and4.15μM(AChE)[1]REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEQian-ShengYu,etal.Anticholinesteraseactivityofcompoundsrelatedtogeneserinetautomers.N-Oxidesand1,2-oxazines.JMedChem.2002Aug15;45(17):3684-91.HanHJ,LeeJJ,ParkSAetal.EfficacyandsafetyofswitchingfromoralcholinesteraseinhibitorstotherivastigminetransdermalpatchinpatientswithprobableAlzheimer'sdisease.JClinNeurol.2011Sep;7(3):137-42.HelenaShifrin,etal.Rivastigminealleviatesexperimentallyinducedcolitisinmiceandratsbyactingatcentralandperipheralsitestomodulateimmuneresponses.PLoSOne.2013;8(2):e57668.RaafatAAbdel-Aal,etal.Rivastigminereversesaluminum-inducedbehavioralchangesinrats.EurJPharmacol.2011Jun1;659(2-3):169-76.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;