番茄红素的提取工艺研究.doc

课题：番茄红素的提取工艺Study on the extraction of lycopene姓名：赵玲学号：0743085096专业：制药工程 一、研究目的和意义：番茄红素(lycopene)是成熟番茄的主要色素,是一种不含氧的类胡萝卜素。在类胡萝卜素中，它具有最强的抗氧化活性。番茄红素清除自由基的功效远胜于其它类胡萝卜素和维生素E，其淬灭单线态氧的速率常数是维生素E的100倍，是迄今为止自然界中被发现的最强抗氧化剂之一。具有极强的清除自由基的能力，对防治前列腺癌、肺癌、乳腺癌、子宫癌等有显著效果，还有预防心脑血管疾病、提高免疫力、延缓衰老等功效，有植物黄金之称，被誉为“21世纪保健品的新宠”。它是自然界中最强的抗氧化剂，其抗氧化作用是?-胡萝卜素的2倍，VE的100倍。在清除人体“万病之源”自由基方面，番茄红素的作用比-胡萝卜素更强大。2003年，美国时代杂志把番茄红素列在“对人类健康贡献最大的食品”之首，番茄红素也因此被称为“植物中的黄金”。目前，番茄红素已在欧美、日本和我国港台地区被广泛接受。对防治前列腺疾病、前列腺癌、肺癌、胃癌、乳癌有奇效，有效抑制癌细胞的扩散和复制，被西方国家称为“植物黄金”，保护细胞DNA免受自由基损害，防止细胞病变、突变、癌变；含强力抗氧化生物活物质，能促使细胞的生长和再生，美容袪皱，延缓衰老，维技皮肤健康。二、相关的学科知识：目前研究番茄红素的提取工艺主要是要解决以下几个问题；（1）预处理对番茄红素提取的影响（2）温度，时间以及皂化对番茄红素的影响总之要提取高质量的番茄红素，除了要把握好反应条件及材料的而选择外，还应积极的寻扎更新的提取方法。 三、检索数据库和检索范围： 所用数据库进入方式检索范围文献类型重庆维普中文科技期刊数据库219992007期刊文献中国期刊全文数据库219992007期刊文献美国工程索引（EI）219992007期刊文献Elsevier Science219992007期刊文献科学引文索引（SCI）219992007期刊文献中国知识产权网/19992007专利说明书 四、检索词：中文：1番茄红素2提取3制备 英文：1 lycopene 2 extraction3 preparetion五、检索式：中文：A （T=番茄红素)*(U=提取)B (T=番茄红素)*(U=提取)+（U=制备）英文：A （T= lycopene）*(U= extraction)B (T= extraction )*(U= extraction)+ (U= preparetion)六、检索结果：（1）重庆维普中文科技期刊数据库（经查证，该数据库均提供原文）：用检索式A共检出文献10篇，选择3篇如下：001【题名】从新鲜番茄中提取番茄红素工艺的研究【作者】曹楠 赵明【原文出处】枣庄学院化学化工系【关键词】番茄红素 提取条件 浓缩 结晶 鉴定【摘要】研究从新鲜番茄中提取番茄红素粗产品，并进一步分离纯化的工艺条件。探索提取溶剂、物料比、提取温度、浸取时间、搅拌条件、冷冻处理对番茄红素提取量的影响，确定以番茄为原料的最佳提取工艺条件，将提取液减压浓缩并结晶纯化得番茄红素。著者文摘002【题名】番茄红素提取工艺研究【作者】宋玉民 刘哲 申少斌【原文出处】西北师范大学化学化工学院【关键词】番茄红素 提取工艺 液相色谱【摘要】为充分利用番茄酱加工业中产生的副产品一番茄皮，采用紫外分光光度法和液相色谱法，研究了从番茄皮中提取番茄红素的最佳提取条件。结果表明，以正己烷为浸提剂，在50下液料比12：1，浸提1h，浸提两次的条件下，番茄红素的提取率达9733，该方法简便、快捷、处理量大，适合工业化生产。著者文摘003【题名】番茄红素的提取及纯化条件的研究【作者】杨春文【机构】甘肃联合大学化工学院【原文出处】2004年 14卷 4期科学与工程 【关键词】番茄 番茄红素 提取 纯化【摘要】对番茄中番茄红素的提取和粗制品的纯化条件进行了研究，实验证实，选用丙酮作为提取剂，液料比8：1，提取温度50，提取时间30min时，提取效果最佳进一步利用单因素分析法和正交实验法确定了洗涤纯化的条件，从而得出碱洗与盐洗的最佳条件碱洗的最佳条件：用1motLNaOH溶液，洗涤时间1h，温度40；盐洗最佳条件：用20NaCl溶液，洗涤时间为1h，洗涤温度50搅拌的纯化效果比不搅拌的好著者文摘用检索式B共检出文献20篇，选择3篇如下：004【题名】番茄红素的提取工艺研究【作者】夏萍 盛建军【机构】河南工业大学化学化工学院,河南郑州450006【原文出处】应用化工1671-3206（2007）10-0975-05【关键词】番茄红素 提取 预处理 影响因素【摘要】鲜番茄制成糊,用Na2CO3溶液皂化,再用稀硫酸中和起泡,过滤。滤饼用乙醇处理过滤后用有机溶剂提取番茄红素。考察了皂化剂用量、皂化时间、乙醇用量、提取剂种类及其用量、料液比、浸提时间、浸提温度、pH值等因素对提取率的影响。结果显示,新鲜番茄中提取番茄红色素的最佳工艺条件为：用0.5 mol/L的Na2CO3溶液对番茄糊进行皂化,物料比为12,皂化温度40,皂化时间30 m in;乙醇番茄（体积质量）为21,处理时间10 m in;用乙酸乙酯和丙酮的混合液进行提取,乙酸乙酯丙酮为12（体积比）,物料比为14,浸提温度45,浸提时间50 m in,pH=7。在此最佳条件下,番茄红素的相对提取率可达85.9。著者文摘005006005【题名】番茄红素的提取研究基本概况【作者】全婧【机构】湖北荆州长江大学生命科学学院食品科学与工程【原文出处】内蒙古科技与经济 1007-6921（2007）08-0090-02【关键词】: 番茄红素 性质 提取 方法【摘要】番茄红素（lycopene）是类胡萝卜素的一种，它是由11个共扼及2个非共扼碳碳双键组成的直链碳氢化合物，具有很强的抗氧化性，是一种很好的食品添加剂。本文介绍了几种常见的番茄红素提取方法，及其稳定性研究的方法。著者文摘 006【题名】超声波提取番茄红素新工艺研究【作者】何晗 王群【机构】绵阳师范学院,绵阳610065【原文出处】2007年 32卷 4期食品科技【关键词】番茄红素 酶提取 促效剂 超声波【摘要】首次研究发现了试剂A促进番茄红素提取效率的新工艺，在此基础上采用超声波提取能进一步提高番茄红素的提取效率和缩短提取时间。在加入04（w/w）的试剂A、pH为6-7、1：1（wv）的料液比的条件下，采用超声波提取4min，能使番茄红素的一次提取率比不用超声波的提取率高出252，并将提取时间从150min缩短到4min；在采用超声波（80W）提取的条件下，加入试剂A的提取率比不加试剂A的提取率高出312。提取时间从12min减少到4min。试验表明采用超声波和提取促效剂A不仅可以大大提高提取效率。还能极大地缩短提取时间。著者文摘（2）中国期刊全文数据库（经查证，该数据库均提供原文）：用检索式A共检出文献38篇，选择2篇如下：008【英文篇名】 Study on the extraction of lycopene【作者中文名】 宋玉民; 刘哲; 申少斌【作者英文名】Yuming Song；Liu Zhe；Shaobin Shen【作者单位】西北师范大学化学化工学院;【文献出处】甘肃科技, Gansu Science and Technology, 编辑部邮箱 2009年 09期 期刊荣誉：ASPT来源刊 中国期刊方阵 CJFD收录刊【关键词】番茄红素; 提取工艺; 液相色谱; 【英文关键词】lycopene; extraction; liquid chromatogram; 【摘要】为充分利用番茄酱加工业中产生的副产品番茄皮,采用紫外分光光度法和液相色谱法,研究了从番茄皮中提取番茄红素的最佳提取条件。结果表明,以正己烷为浸提剂,在50下液料比121,浸提1h,浸提两次的条件下,番茄红素的提取率达97.33%,该方法简便、快捷、处理量大,适合工业化生产。【英文摘要】 To take full advantage of tomato paste processing industry by-products produced - tomato skin, using ultraviolet spectrophotometry and liquid chromatography to study the skin from the tomato lycopene extract the best extraction conditions. The results showed that n-hexane as the extraction agent, at 50 , liquid feed ratio 12:1, extraction 1h, extracted twice under the condition of lycopene extraction rate of 97.33%, the method is simple, quick, dealing with large quantities suitable for industrial production. 009【中文篇名】番茄红素提取与分离的研究【英文篇名】 Study on the extraction and abruption of lycopene【作者中文名】汪雨潇【作者英文名】Yuxiao Wang【作者单位】中国药科大学;【文献出处】化学工程与装备, Chemical Engineering & Equipment, 编辑部邮箱 2009年 01期 期刊荣誉：ASPT来源刊 CJFD收录刊【关键词】番茄红素; 分离; 提取; 分析【英文关键词】lycopene; abruption ；extraction; analyse; 【摘要】番茄红素(lycopene)是类胡萝卜素的一种,它是由11个共扼及2个非共扼碳碳双键组成的直链碳氢化合物,具有很强的抗氧化性,能起到防癌抗癌,提高免疫力,延缓衰老等多种保健功能,是一种很好的食品添加剂。本文综述了番茄红素研究的提取方法、纯化方法以及分析测定方法。【英文摘要】Lycopene is a carotenoid, which is conjugate by 11 and two non-conjugated carbon - carbon double bond composed of straight-chain hydrocarbons, which has strong antioxidant, can play anti-cancer, enhance immunity, anti-aging and other health-care functions, is a good food additive. In this paper, the study of lycopene extraction and purification methods, and detection methods.用检索式B共检出文献40篇，选择2篇如下：010【英文篇名】 Extraction of Lycopene from Tomato and its Properties 【作者中文名】许庆陵; 陆海霞; 吴丽容; 邱浩纯; 刘文丹;【作者英文名】 XU Qing-ling; LU Hai-xia; WU Li-rong; QIU Hao-chun; Liu Wen-dan（School of Chemistry & Chemical Engineering; Guangzhou University; Guangzhou 510006; China ）;【作者单位】广州大学化学化工学院;【文献出处】 宁波现代食品科技, Modern Food Science and Technology, 编辑部邮箱 2009年 01期 期刊荣誉：ASPT来源刊 CJFD收录刊【关键词】番茄红素; 浸提; 微波提取; 稳定性【英文关键词】 Lycopene; extraction; microwave extraction; stability; 【摘要】用番茄作原料,以V(丙酮):V(水)=10:1的丙酮溶液作为提取溶剂,以测定番茄红素紫外扫描光谱为依据,研究了溶剂浸提法、微波提取法提取番茄红素的工艺条件及番茄红素性质。结果表明:微波提取法比溶剂浸提法有较高的提取率,并且节省时间和提取试剂;番茄红素在472nm波长处有最大吸收峰;番茄红素对光、强酸、高温、Fe3+和Cu2+不稳定,对氧化剂、还原剂、弱酸、碱等较稳定。【英文摘要】The application of solvent extraction and microwave radiation extraction for lycopene extraction from tomatoes was studied and the properties of lycopene were investigated.The results showed that Microwave radiation extraction was more suitable for lycopene extraction due to its higher extraction rate,shorter extraction time and less extraction reagent dosage than solvent extraction.Lycopene had the maximum absorption peak at 472 nm.It was unstable to light,strong acidic,high temperature,Fe3 + and Cu2 +,whi. ：011【英文篇名】 Experimental Study on Extraction Technology Condition for Lycopene【作者中文名】 韩国廷; 【作者英文名】 HAN Guo-ting（Vocational Technical College; Liaoning University of Petroleum and Chemical Technology; Fushun; Liaoning 113001）;【作者单位】 辽宁石油化工大学职业技术学院;【文献出处】安徽农业科学, Journal of Anhui Agricultural Sciences, 编辑部邮箱 2008年 30期 期刊荣誉：中文核心期刊要目总览 ASPT来源刊 CJFD收录刊【关键词】番茄红素; 乙酸乙酯; 萃取;【英文关键词】 Lycopene; Ethyl acetate; Extraction;【摘要】 目的确定番茄红素的提取工艺。方法采用正交试验,研究液料比、提取温度、提取时间及提取次数对番茄红素提取率的影响。结果乙酸乙酯的浸提效果最好,故选用乙酸乙酯作为浸提溶剂。随着液料比的升高,番茄红素提取率增加,当液料比大于41(ml/g)时,色素提取率增加缓慢。当pH值小于6时,随着pH值的增大,色素提取率增加;当pH值大于6时,随着pH值的增大,色素提取率降低。各因素对番茄红素提取率的影响由大到小依次为:液料比提取次数提取时间提取温度。结论番茄红素的最佳提取工艺为:液料比为41(ml/g),提取时间50 min,提取温度45,提取次数3次,该条件下,番茄.【英文摘要】 Objective The study was to determine the extraction technology for lycopene.Method The orthogonal test was taken to study the effects of liquid-to-solid ratio,extraction temperature,extraction time and extraction times on the extraction rate of lycopene.Result The extraction effect with ethyl acetate was the best,so ethyl acetate was selected as the extraction solvent.With the increasing of liquid-to-solid ratio,the extraction rate of lycopene was increased and when liquid-to-solid ratio was above 41.（3）中国知识产权网(经查证，该处提供专利说明书)用检索式A共检出文献16篇，选择3篇如下：012【名称】一种从番茄中提取番茄红素的方法 【申请号】03115731.9【申请人】刘耀北【发明人】刘耀北 【摘要】本发明属于食品技术领域。本发明公开了一种从番茄中提取番茄红素的工业化生产的皂化方法。本发明的方法优于现有技术的“溶剂法”和“萃取法”，具有工艺简单，生产周期短，设备投资少，效率高的优点，并且无三废排放，不产生二次污染，宜于规模型工业化生产。 013【名称】从番茄皮渣中提取番茄红素的方法【申请号】200710150585.5【申请人】 天津科技大学 【发明人】张泽生;赵娟娟;王 浩 【摘要】本发明涉及一种从番茄皮渣中提取番茄红素的方法，其步骤是(1)将番茄皮渣经皮籽分离工序，得到番茄皮和番茄籽；(2)将(1)得到的番茄皮进行粉碎，得到番茄皮浆；(3)对番茄皮浆进行预处理，脱水除杂；(4)把处理后的番茄皮浆加入有机溶剂进行提取，收集提取液，(5)真空浓缩，即制得番茄红素油树脂。本发明提供的提取番茄红素的方法，是利用了番茄加工业废弃物番茄皮渣作为原料，得到高含量的番茄红素产品。本方法简便易行，原料来源广泛，成本低廉。本发明的实施有利于补充番茄红素生产的原料来源，同时避免了资源浪费和环境污染，又能增加番茄产业的经济效益，开发前景非常广阔。 014【名称】 一种快速提取番茄红素的方法 【申请号】200710131868.5【申请人】江南大学【发明人】张连富;刘泽龙 【摘要】一种快速提取番茄红素的方法，属于食品配料技术领域。本发明从富含番茄红素的原料中提取番茄红素，将富含番茄红素的原料经初步处理后，用超声波/微波协同技术辅助溶剂回流提取番茄红素，浓缩后得番茄红素油树脂产品；并回收溶剂。本发明步骤简单，提取时间大大缩短，避免在提取过程中番茄红素的损失；提取率较高，最高提取率可达到97；提取过程采用密闭体系，溶剂消耗少，降低了成本，同时提高了生产的安全性；采用微波为加热源，能量直接作用于萃取体系，减少了能量的浪费，具有节能的特点（4）美国工程索引（EI）用检索式A共检出文献30篇，选择2篇如下：015Title: Study on methods of lycopene extraction (番茄红素的提取方法研究)Authors: Deng, Yu1 ; Zhang, Wei-Qiang1. Source: Huagong Xiandai/Modern Chemical IndustryAbstract: Methods of lycopene extraction from tomato were studied. Effects from extraction temperature, time, feedstock ratio and solvent on extraction result were studied and optimal conditions were determined. Lycopene can be completely extracted by using No.6 solvent for the second-level extraction from tomato pulp for a duration of 2-3 hours at ratio of tomato mass to solvent volume of 0.33 g/ml, a pH value of 6 and 35C and with the addition of assistants. When using microwave radiation, best results can be achieved at a microwave power of 200 W, an extraction time of 80 s and a ratio of tomato mass to solvent volume of 0.5 g/ml.ISSN: 02534320原文收藏：由资料来源查电子期刊收录及国内馆藏联合目录，得Elsevier Science上有收录。016Title: Application of high hydrostatic pressure processing of food to extracting lycopene from tomato paste waste （食品加工过程中的高静水压处理方式对从番茄酱中提取番茄红素的应用）Authors: Jun, X.1 Source: High. Pressure. Res. v 26p 33-41 Abstract: The application of high hydrostatic pressure (HHP) processing of food to extracting lycopene from tomato paste waste was studied. Various experimental conditions of HHP processing process, such as solvents (chloroform, 95% ethanol and distilled water), ethanol concentration (45-95%, v/v). pressure (100-600MPa), duration (1-10min) and solid/liquid ratio (1:1 to 1:8g/ml), were investigated to optimize the extraction process. The experimental results of HHP showed that more lycopene can be extracted from tomato paste waste in only l min at room temperature without any heating process. The highest recovery (92%) was obtained by performing the extractions at 500 MPa pressure, 1 min duration, 75% ethanol concentration, and 1:6 (g/ml) solid/liquid ratio. From the viewpoints of extraction time, the extraction yield and the extraction efficiency, extraction by HHP shows a bright prospect for extracting lycopene from tomato paste waste.ISSN: 08957959 用检索式B共检出文献32篇，选择2篇如下：017Title: Supercritical CO2 extraction of lycopene from tomato industrial waste （番茄工业废物中番茄红素的超临界二氧化碳萃取法）Authors: Nobre, Beatriz P.1 ; Pessoa, Fernando L. P.2 ; Palavra, Antnio F.3 ; Mendes, Rui L.1 Source: CHISA 2006 - 17th International Congress of Chemical and Process Engineering v 93 n 8 Oct 1998 p 255-260 Abstract: Supercritical CO2 extraction of lycopene from tomato industrial waste (mixture of skins and seeds) was carried out in a flow apparatus at temperatures of 40, 60 and 80C and pressures of 200 and 300 bar. The effects of the composition of the starting waste, pressure and temperature on the extraction yield were studied. The yield and recovery of trans-lycopene depended on the composition of the starting material: for a batch with lower content in lycopene (128 g/g, dry basis), there was a quick recovery of the almost all the lycopene (93 %), with a consumption of CO2 of 78 g per g of dry tomato waste, while for the batch with higher content (214 g/g, dry basis) it was obtained a recovery of 86% of the lycopene using 220 g of CO2 per g of dry tomato waste. These supercritical extractions were carried out at a pressure of 300 bar and a temperature of 60C. When the pressure was lowered to 200 bar the recovery of the trans-lycopene dropped to 30 %. The effect of the extraction temperature is more complex. When the temperature increased from 40 to 60C the recovery increased, but a further rise of the temperature to 80C led to a decrease of the trans-lycopene recovery, although the total lycopene (cis plus trans) remained the same of that at 60C. An empirical model was used to describe the cumulative curves of the supercritical CO2 extraction of the lipids (containing the lycopene) from the tomato waste and a good agreement was reached.ISSN: 8086059456 018Title: A review on lycopene - Extraction, purification, stability and applications （回顾关于番茄红素提取，净化）Authors: Choksi, Pratik M.1 ; Joshi, Vishal Y.2, 3 Source: Choksi, Pratik M.1 ; Joshi, Vishal Y.2, 3 v10 n 2 April/June 2007 p 289-298 Abstract：Lycopene is a functional component of great dietary importance obtained from many plant sources. In this article, we address the extraction of lycopene from various sources by efficient analytical support. Extraction, storage, and handling are described in detail. We also describe the effect of heat and time on amount of lycopene during extraction. Purification and applications are considered to understand lycopenes nutraceutical, epidemiological, and pharmaceutical importance, as well.ISSN: 10942912（5）SCI（经查证，该数据库均提供原文）用检索式A检出文献30篇，选择3篇如下：019Title: Effects of supercritical fluid extraction parameters on lycopene yield and antioxidant activity(超临界流体法萃取特性对番茄红素的产量和抗氧化剂活性的影响)Author(s): Yi C (Yi, Chun)1,2, Shi J (Shi, John)1, Xue SJ (Xue, Sophia Jun)1, Jiang YM (Jiang, Yueming)2, Li D (Li, Dong)3 Times Cited: 1 Abstract: The effects of various parameters of supercritical carbon dioxide (SC-CO2,) fluid extractions of tomato skins on the extraction yields and antioxidant activities of lycopene-rich extracts were investigated. A Box-Behnken design was applied to study the effects of three independent variables (temperature ranging from 40 to 100 degrees C, pressure ranging from 20 to 40 MPa, and flow rate ranging from 1.0 to 2.0 mL/min) on lycopene yield. The model showed good agreement with the experimental results, by the coefficient of determination (r(2) = 0.9834). Temperature, pressure, and the quadratic term for the temperature of SC-CO2 extraction were large significantly positive factors affecting lycopene yield (P 0.05). The maximum total lycopene content of 3 1.25 mu g/g of raw tomato was extracted at the highest temperature of 100 degrees C, 40 MPa and 1.5 mL/min. TEAC assay was applied to assess the antioxidant activity of lycopene-rich extracts from SC-CO2 fluid extraction. The effects Of SC-CO2 fluid extraction parameters on the antioxidant activities of the extracts differed with the yield. For each unit of lycopene extract, the antioxidant activity level was constant below 70 degrees C, but then gradually decreased above 70 degrees C due to isomerization occurring as a result of the higher temperature. The ratio of all-trans-lycopene to the cis-isomers changed from 1.70 to 1.32 when the operating temperature was adjusted from 40 to 100 degrees C, indicating an increased bioavailability due to the generation of the cis-isomers. No significant effects Of pressure or flow rate of SC-CO2 fluid extraction on the antioxidant activity were observed. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved. 原文收藏：FOOD CHEMISTRY 卷: 113 期: 4 页: 1088-1094020Title: Extraction of pure lycopene from industrial tomato by-products in water using a new high-pressure process （在水中用新式高压法从番茄中提取纯净的番茄红素的工业方法）Author(s): Naviglio D (Naviglio, Daniele)1, Pizzolongo F (Pizzolongo, Fabiana)1, Ferrara L (Ferrara, Lydia)2, Aragon A (Aragon, Alejandro)3, Santini A (Santini, Antonello)1 Abstract: Lycopene, a precursor of beta-carotene with a well-known antioxidant activity, contained in many natural products such as tomato (Lycopersicon esculentum Mill.), watermelon, red pepper and papaya, is usually recovered from natural vegetal sources using organic solvents and a purification step. In this paper an innovative process for the extraction of pure lycopene from tomato waste in water that uses the Naviglio (R) extractor and water as extracting phase is presented.RESULTS: Lycopene was obtained in the all-trans form at a very high grade of purity, not less than 98% (w/w), with an average recovery of 14% (w/w). The availability of high-purity trans-lycopene allowed measurement of the molar absorption coefficient. An alternative procedure for high-performance liquid chromatographic analysis using a phenyl-hexyl silicone phase as inverse phase and a linear gradient in water and acetonitrile is also described.CONCLUSIONS: The use of water as extracting phase considerably reduces the cost of the entire process when compared with the commonly used solvent-based procedure or with the newer supercritical extraction process of lycopene from tomato waste. Lycopene, not soluble in water, was recovered in a quasi-crystalline solid form and purified by solid-phase extraction using a small amount of organic solvent. (c) 2008 Society of Chemical IndustryTimes Cited: 0ISSN: 0022-5142 原文收藏：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 卷: 88 期: 14 页: 2414-2420 出版年: NOV 2008 用检索式B检出文献30篇，选择2篇如下：021Title: Extraction conditions affecting supercritical fluid extraction (SFE) of lycopene from watermelon (提取条件对超临界流体从西瓜中萃取番茄红素的影响)Author(s): Katherine LSV (Katherine, L. S. Vaughn)1, Edgar CC (Edgar, C. Clausen)2, Jerry WK (Jerry, W. King)2, Luke RH (Luke, R. Howard)3, Julie CD (Julie, Carrier Danielle)1 Source: BIORESOURCE TECHNOLOGY 卷: 99 期: 16 页: 7835-7841Abstract: Lycopene, a carotenoid linked to protection against certain forms of cancer, is found in produce such as papaya, red-fleshed tomatoes, grapefruit and watermelon. The preparation of a supercritical CO2 (SC-CO2) watermelon-lycopene extract could serve as a food grade source of this carotenoid. This study established preliminary conditions for enhancing SGCO(2) extraction of lycopene from watermelon. Freeze-dried watermelon was extracted