生命科学导论论文翻译.docx

生命科学导论论文翻译IL-23 signaling enhances Th2 polarization and regulatesallergic airway infammation白细胞介素发出信号增强TH2细胞极化和调节过敏通道炎症Keywords: cytokines, helper T cells, T cell differentiation, allergic airway inflammation关键词：细胞因子，辅助型T细胞，T细胞变异，过敏通道炎症IntroductionAllergic asthma is a common health problem in de-veloped countries. It is characterized by chronic airwayinfammation associated with a T helper (Th) 2 immune response to environment allergens. Upon allergen challenge, native CD4 T cells differentiate into a prevailing Th2 effector phenotype, and these cells predominantly secret interleukin-4 (IL-4), IL-5, and IL-13. Furthermore,these cytokines induce the recruitment oeosinophils , mast cells and lymphocytes, hyperplasia of smooth muscle and goblet cells, and airway hyper responsiveness, which are oft en associated wi th increased serum IgE concentration 1-3.IL-23 is a member of the IL-12 family of heterodimeric cytokines. It is composed of a unique p19 subunit and a common p40 subunit sharing with IL-12 4. IL- 23 binds to a heterodimeric receptor composed of the IL-12 receptor 1 (IL-12R1) and IL-23 receptor (IL-23R) and this subsequently activates Jak2, Tyk2, and signal transducers and activators of transcription (STATs) 1, 3, 4, and 5 5. Like IL-12, IL-23 is primarily secreted by activated DCs, monocytes, and macrophages 6. It has been shown that IL-23 is important in some infammatory diseases including experimental autoimmune encephalitis, collagen-induced arthritis, and i ntestinal infl ammation 7-9. Moreover, polymorphisms in the gene encoding the IL-23R are an i mport ant suscepti bility fact or for these disorders 10-12.介绍：过敏性哮喘在发达国家是一种常见的健康问题。它的特点是与对环境过敏原有免疫反应辅助T细胞相联系的慢性气道炎症。在过敏原的挑战下，我们细胞的分化成普遍的TH2效果显性，而这些细胞主要隐藏白细胞介素4（IL - 4），IL - 5，13。此外，这些细胞因子诱导吸收oeosinophils，肥大细胞和淋巴细胞增生，平滑肌细胞和杯状细胞，和人工智能rway高反应性，这是经常联系与增加血清抗体浓度 1 。白细胞介素- 23是一个成员的家庭的异二聚体细胞因子IL - 12。它是由一个独特的肿瘤细胞亚基亚基和共同分享与IL - 12 4 。白细胞介素- 23受体结合到一个异二聚体组成的12受体1（il-12r1）和IL - 23受体（il-23r）和随后激活JAK 2，Ty k2，及信号转导和转录激活因子（转录）1，3，4，和5 5 。像是主要分泌的IL 12，激活细胞，单核细胞，巨噬细胞