Time Domain OCT Predpharma.ppt

rtvue100thenextgenerationoct,principlesofocttechnology,opticalcoherencetomography(oct)usesaprinciplecalledlowcoherenceinterferometrytoderivedepthinformationofvariousretinalstructuresthisisperformedbycomparingthetimedifferenceinreflectedlightfromtheretinaatvariousdepthswithareferencestandarddifferencesbetweenthereflectedlightandthereferencestandardprovidestructuralinformationintheformofanascan,principlesofocttechnology,ana-scanistheintensityofreflectedlightatvariousretinaldepthsatasingleretinallocationcombiningmanya-scansproducesab-scan,a-scan,a-scan,+,+,.,=,b-scan,a-scans,retinaldepth,reflectanceintensity,fourierdomainoctrtvue100,opticalcoherencetomography(oct)providescrosssectionalimagingoftheretinaspectrometryandfourierdomainmethodsallowhighspeeddatacapture(26,000ascanspersecond)broad-bandlightsourceprovideshighdepthresolution(5microns),theevolutionofocttechnology,65xfaster2xresolution,zeissoct1and2,1996,zeissstratus2002,optovuertvue2006,26,000,400,100,16,10,5,speed(a-scanspersec),resolution(mm),fourierdomainoct,timedomainoct,evolutionofcommercialoct,1996,2002,2006,oct1(timedomain),stratusoct(timedomain),rtvue(fourierdomain),timedomainoct,sld,lens,detector,dataacquisitionprocessing,combineslightfromreferencewithreflectedlightfromretina,distancedeterminesdepthinascan,referencemirrormovesbackandforth,scanningmirrordirectssldbeamonretina,interferometer,broadbandlightsource,createsa-scan1pixelatatime,finala-scan,processrepeatedmanytimestocreateb-scan,slidecourtesyofdr.yiminwang,usc,fourierdomainoct,sld,spectrometeranalyzessignalbywavelength,fft,gratingsplitssignalbywavelength,broadbandlightsource,referencemirrorstationary,combineslightfromreferencewithreflectedlightfromretina,interferometer,spectralinterferogram,fouriertransformconvertssignaltotypicala-scan,entirea-scancreatedatasingletime,slidecourtesyofdr.yiminwang,usc,processrepeatedmanytimestocreateb-scan,fourierdomainoctsimultaneousentirea-scanatonce2048pixelsperascan26,000ascanspersecond1024a-scansin0.04secfasterthaneyemovements,timedomainoctsequential1pixelatatime1024pixelspera-scan400ascanspersecond512a-scansin1.28secslowerthaneyemovements,higherspeed,higherdefinitionandhighersignal.,1024a-scansin0.04sec,smallbloodvessels,is/os,choroidalvessels,slidecourtesyofdr.davidhuang,usc,fourierdomainoct,highspeedreduceseyemotionartifactspresentintimedomainocthighresolutionprovidesprecisedetail,allowsmorestructurestobeseenlargerscanningareasallowdatarichmaps&accurateregistrationforchangeanalysis3-dscanningimprovesclinicalutility,highspeedallows3-dscanning,b-scansprovidehighresolutiondetail,retinallayerswithrtvue&histology,ilm,nfl,gcl,ipl,inl,opl,onl,pris/os,rpe,choriocapillarisandchoroid,fovea,parafovea,temporal,nasal,maculathicknessmaprevealsedema,rpeelevationmaprevealsdrusen&cnv,rpeelevationmaprevealscnv,changeanalysisformacula,glaucomaanalysis,rnflthicknessmapneuralretinalrimcuparearnfltsnitgraphat3.45mmcircle,measuringtheganglioncells,innerretinallayerprovidesganglioncellassessment:axons=nervefiberlayercellbody=ganglioncelllayerdendrites=innerplexiformlayer,imagescourtesyofdr.outan,usc,ganglioncelllayerinmaculaanalyzedforglaucoma,innerretinasegmentationprovidesthicknessof:rnfllayerganglioncelllayerinnerplexiformlayer,normalvsglaucoma,normal,glaucoma,cup,rim,rnfl,innerretinamaculamap,retinaexamples,normal,rodconedystrophy,imagescourtesyofdr.jenniferlim,usc,courtesy:michaelturano,cracolumbiauniversity.,cystoidmaculaedema,courtesy:michaelturano,cracolumbiauniversity.,horizontal,vertical,diabeticretinopathy,imagescourtesyofdr.tano,osakauniversity,centralretinalveinocclusion,imagescourtesyofdr.tano,osakauniversity,horizontal,vertical,amd-classiccnv,imagescourtesyofdr.tano,osakauniversity,idiopathiccnv,imagescourtesyofdr.tano,osakauniversity,horizontal,vertical,maculahole,imagescourtesyofdr.tano,osakauniversity,courtesy:michaelturano,cracolumbiauniversity.,diabeticmaculaedemawithepiretinalmembrane,centralserouschorioretinopathywithped,earlyphasefa,56yearoldfemale,sub-retinalfluid,ped,imagescourtesyofdr.tano,osakauniversity,operculum,courtesy:michaelturano,cracolumbiauniversity.,stage3fullthicknessmacularhole,centralserouschorioretinopathy,imagescourtesyofdr.tano,osakauniversity,epiretinalmembrane,imagescourtesyofdr.tano,osakauniversity,retinitispigmentosa,imagescourtesyofdr.tano,osakauniversity,courtesy:michaelturano,cracolumbiauniversity.,vitreomaculartractionsyndromewithcme,patientmbneovascularamd,fundusphotograph,fa,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientmbneovascularamd,fluidaccumulation,cnv,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientmbneovascularamd,fullretinalthicknessmap,rpeelevationmap,rpeelevationduetocnv,largeareaofabnormallythickretinafromintraretinalfluidaccumulation,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientwbneovascularamd,fundusphotograph,fa,86yearoldmale,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientwbneovascularamd,cnv,date:1/10/07,3-devaluationrevealsextentofcnv,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientwbneovascularamd,fullretinalthicknessmap,rpeelevationmap,rpe/choroiddisruptionidentifiespresenceofcnv,someabnormalthickeningandthinning,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientwbneovascularamd,1/10/07,2/23/07,b-scancomparison,fullretinalthickness,rpeelevation,treatment2/7lucentis2/14pdt,thinningofretinaandimprovementinrpeinresponsetotreatment,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientedneovascularamd,84yearoldmale,initialexam12/13/2006,fashowsleakagejustsuperiortofovea,fullretinalthicknessshowsnothickening,rpeelevationmapclearlyshowsareaofcnvsuperiortofovea,fa,fullretinalthicknessmap,rpeelevationmap,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientedneovascularamd,initialexam:12/13/2006,follow-upexam:3/20/2007,rpe/choroidshowssomereductioninheight,butoverallretinalthicknessincreasesduetointra-retinalfluidaccumulation,treatment1/17macugen3/14-macugen,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientedneovascularamd,casecourtesyofdr.nalinmehta,coloradoretinacenter,totalretinalthicknessincreases,rpeelevationdecreases,patientwwamd,76yearoldmale.,drusen,peds,casecourtesyofdr.nalinmehta,coloradoretinacenter,patientwwamd,fullretinalthicknessmap,rpeelevationmap,localizedelevationsreveallocationofpedanddrusen,fullretinalthicknessmapnormal,casecourtesyofdr.nalinmehta,coloradoretinacenter,comparisonofstratusocttortvueoct,comparison,rtvue,stratus,fourierdomainoct26,000ascanspersecond5mdepthresolutionretinaassessmentdensefullretinalthicknessmaprpeelevationmap3-dmaculascansglaucomaassessmentrnflmapinnerretinalthicknessmap(ganglioncellassessment-axon+cellbody+dendrites)opticdisc,rtvueis65timesfasterrtvuehastwicethedepthresolution,timedomainoct400ascanspersecond10mdepthresolutionretinaassessmentsparseretinalthicknessmapforretina(97%interpolated)glaucomaassessmentrnflringforglaucoma(tsnitcurve),comparisonofstratusocttortvueoct,glaucomacomparison,rtvue,stratus,datacaptured:9510ascans(pixels)time:370msecareacovered:4mmdiametercircle,rtvuehas97%moredatartvueisover5timesfaster,datacaptured256ascans(pixels)time:1.92secondsareacovered:ringat3.45mmdiameter,providescuparearimarearnflmaptsnitgraph,providestsnitgraph,rtvueprovidescomprehensiveglaucomainformation,plus,rtvuehasexclusiveretinalganglioncelllayerassessment,datacaptured:14,810ascans(pixels)time:570msecareacovered:7x7mm,providesinnerretinamapganglioncellassessmentinmacula,nocomparison,rtvueprovidesdirectganglioncellinformationinnerretinaanalysis:rnflganglioncellbodyinnerplexiformlayer,rtvuecanprovide3-dimagingoftheopticdiscandrnfl,nocomparison,datacaptured:51,712ascans(pixels)time:2secondsareacovered:4x4mm,provides3dmap,rtvueprovides3dimageofopticdiscandparapapillaryrnfl,comparisonofstratusocttortvueoct,retinacomparison,rtvue,stratus,datacaptured:19,496ascans(pixels)time:780msecareacovered:5x5mm,rtvuehas96%moredatartvueisover2.4timesfaster,datacaptured768ascans(pixels)time:1.9secondsareacovered:circle6mmdiameter,providesdenseretinalthicknessmap,providessparseretinalthicknessmap97%interpolatedbetweenlines,rtvueprovidesmoredataandamoredetailedthicknessmap,rtvuehas3dimagingofthemacula,datacaptured:51,7212ascans(pixels)time:2secondsareacovered:4x4mm,provides3dmapofthemacula,nocomparison,rtvueprovides3-dimageofmaculaforacomprehensivereviewofb-scansoverlargearea,plus,rtvuehasrpeelevationmapfordrusenandcnv,datacaptured:19,496ascans(pixels)time:780msecareacovered:5x5mm,providesrpeelevationmap,rtvuerpeelevationmaprevealslocationandextentofdrusenandcnvwhichismissedbyretinalthicknessmaps,nocomparison,rtvuedetails,scanspeed:26,000ascansperseconddepthresolution:5micronstransverseresolution:15micronsframera