Table 1 Identification of urinary biomarkers in JS cases在JS例尿生物标志物的鉴定1表.doc

table 1. clinical characteristics of the subjects at baselinesamplesjsyahyihcontrolsample no.20191412age4864610517456sex (f/m)9/1110/97/76/6bmi(kg/m2)22.72.9623.81.6825.712.8422.642.51alt (u/l)168.85142.15146.29123.78131.37109.1274.8965.02ast (u/l)133.2381.56127.16102.37156.68114.9795.3173.31total bilirubin (mg/dl)4.052.644.522.413.973.161.261.19direct bilirubin(mg/dl)2.531.833.562.662.731.921.41 1.33indirect bilirubin(mg/dl)1.471.131.441.091.350.510.76 0.35table 2. identification of urinary biomarkers in js cases. rtm+h+m-h-formulanamep-value1.85184.1916c9h13no3epinephrine0.030.41228.2365c9h13n3o4deoxycytidine0.011.15262.3297c11h19no6methylglutarylcarnitine0.023.42247.1059c12h22o53-hydroxydodecanedioic acid0.055.58149.2452c9h8o2cinnamic acid0.001.18223.1942c10h9no54-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid0.001.96181.2324c9h12n2o2tyrosinamide0.002.11227.2702c10h14n2o4porphobilinogen0.027.64289.4044c18h24o316b-hydroxyestradiol0.010.96341.3072c21h40o35-oxo-heneicosanoic acid0.050.44197.0513c6h12o7gluconic acid0.002.50265.1882c13h16n2o4alpha-n-phenylacetyl-l-glutamine0.012.81235.1163c12h14n2o35-methoxytryptophan0.043.37105.0312c4h8o33-hydroxybutyric acid0.035.52423.2180c12h23o14plactose 6-phosphate0.046.76591.3339c33h42n4o6d-urobilinogen0.012.61261.1786c11h20n2o5l-gamma-glutamyl-l-leucine0.022.94281.1002c13h16n2o5l-beta-aspartyl-l-phenylalanine0.045.50254.1301c9h11n5o4neopterin0.045.91247.1327c9h14n2o65,6-dihydrouridine0.050.70194.2085c10h11no32-methylhippuric acid0.032.23148.1141c5h9no4l-glutamic acid0.032.55424.4137c25h45no4linoelaidyl carnitine0.002.88217.1739c8h16n4o3n-a-acetyl-l-arginine0.003.45213.0921c10h12o5vanillactic acid0.004.98203.2635c8h18n4o2dimethyl-l-arginine0.057.04293.3652c19h32o2androstanediol0.051.19319.4167c11h15no10beta-citryl-l-glutamic acid0.021.74176.040c6h11no3sn-formyl-l-methionine0.002.23309.5566c12h17n5o5n2,n2-dimethylguanosine0.013.85302.5163c15h17n3o4indoleacetyl glutamine0.016.92480.3846c25h39no6sn-acetyl-leukotriene e40.008.85495.9742c27h44o8pregnanediol-3-glucuronide0.011.16188.3128c10h7no3kynurenic acid0.042.28189.2368c6h6o7oxalosuccinic acid0.034.01193.2905c6h10o7iduronic acid0.045.51186.7564c9h16o4azelaic acid0.017.93213.4360c12h22o33-oxododecanoic acid0.022.22381.4092c14h17n5o8succinyladenosine0.006.48541.9970c27h42o11cortolone-3-glucuronide0.021.24263.0144c9h12o7s3-methoxy-4-hydroxyphenylglycol sulfate0.011.7283.0659c16h12o5glycitein0.006.22382.4537c19h28o6s3b,16a-dihydroxyandrostenone sulfate0.030.43396.0564c12h19n3o8s25-taurinomethyl-2-thiouridine0.00table 3. identification of urinary biomarkers in yah cases. rtm+h+m-h-formulanamep-value1.18223.1942c10h9no54-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid0.001.96181.2324c9h12n2o2tyrosinamide0.007.64289.4044c18h24o316b-hydroxyestradiol0.011.26216.0146c10h9n5okinetin0.012.11227.2702c10h14n2o4porphobilinogen0.022.61188.0689c11h9no2indoleacrylic acid0.012.61130.0635c5h7no3pyrroline hydroxycarboxylic acid0.005.94463.4874c25h34o86-dehydrotestosterone glucuronide0.032.25136.1113c5h5n5adenine0.042.94235.1105c8h14n2o6l-beta-aspartyl-l-threonine0.025.83286.2001c15h27no42-octenoylcarnitine0.027.44467.3206c27h46o4scholesterol sulfate0.000.47241.1267c10h16n4o3homocarnosine0.010.96341.3072c21h40o35-oxo-heneicosanoic acid0.032.64409.4793c29h60nonacosane0.023.67209.0771c11h12o4benzylsuccinic acid0.035.89247.1319c10h18n2o5l-gamma-glutamyl-l-valine0.010.48216.0224c4h10no7po-phospho-4-hydroxy-l-threonine0.001.28443.1118c17h22n4o8ss-(4-nitrobenzyl)glutathione0.002.55248.1070c10h17no6malonylcarnitine0.002.61235.1106c12h14n2o35-methoxytryptophan0.013.35105.0322c2h4n2o3urea-1-carboxylate0.044.32200.0369c4h10no6po-phosphothreonine0.025.5254.1390c13h19no43-indolecarboxylic acid0.011.24263.0144c9h12o7s3-methoxy-4-hydroxyphenylglycol sulfate0.041.7283.0659c16h12o5glycitein0.048.04266.6464c9h16o93-deoxy-d-glycero-d-galacto-2-nonulosonic acid0.001.73177.0224c5h10n2o3scysteinylglycine0.004.84204.0662c11h11no35-methoxyindoleacetate0.016.22382.4537c19h28o6s3b,16a-dihydroxyandrostenone sulfate0.012.23309.5566c12h17n5o5n2,n2-dimethylguanosine0.007.91461.8676c26h38o7retinyl beta-glucuronide0.021.58180.05c6h7n5o28-hydroxy-7-methylguanine0.002.63172.9896c6h6o4sphenyl sulfate0.002.88188.0338c10h7no3n-acetylisatin0.016.57540.2884c24h47no10spsychosine sulfate0.037.26460.2827c30h39no3arachidonoyl-amc0.022.7163.0407c9h8o3enolphenylpyruvic acid0.033.92343.1388c16h24o8iridotrial glucoside0.015.67389.0929c16h22o11monotropein0.00table 4. identification of urinary biomarkers in yih cases. rtm+h+m-h-formulanamep-value0.74173.0915c8h12o42-octenedioic acid0.023.40130.0479c5h7no3pyroglutamic acid0.003.40265.1126c13h16n2o4alpha-n-phenylacetyl-l-glutamine0.011.08166.0705c6h7n5o3-methylguanine0.022.23180.0861c7h9n5o7-aminomethyl-7-carbaguanine0.010.57203.1489c10h18o4sebacic acid0.032.13315.0737c13h14o9beta-d-glucopyranuronic acid0.043.81215.117c14h14o2(+)-(1r,2r)-1,2-diphenylethane-1,2-diol0.000.40212.0313c10h13no43-methoxytyrosine0.052.86201.9941c3h7no5s2cysteine-s-sulfate0.043.40248.0926c10h17no6malonylcarnitine0.014.34560.1141c15h23n5o14p2adenosine diphosphate ribose0.004.80368.0904c14h25no102-acetamido-2-deoxy-6-o-a-l-fucopyranosyl-d-glucose0.000.48216.0132c9h10clno33-chlorotyrosine0.001.89400.1078c15h23n6o5ss-adenosylmethionine0.022.15357.1026c20h36o5prostaglandin f1a0.012.86292.0322c11h17no6shawkinsin0.044.79544.1176c27h29no11adriamycin0.025.51318.1475c19h27no3nateglinide0.000.5286.0707c4h7no2-pyrrolidinone0.010.75143.1158c8h14o22-octenoic acid0.011.97502.0894c18h35n3o13d-glucosaminide0.002.86354.0206c13h11n3o5s22-hydroxytenoxicam0.003.40287.0994c19h26o2androstenedione0.005.64389.0938c18h18n2o8dopaxanthin0.006.66541.2570c27h42o11cortolone-3-glucuronide0.012.79180.3030c6h7n5o28-hydroxy-7-methylguanine0.026.79479.2260c25h36o911-oxo-androsterone glucuronide0.001.19319.4167c11h15no10beta-citryl-l-glutamic acid0.013.85302.5163c15h17n3o4indoleacetyl glutamine0.000.98269.0042c18h22o2estrone0.001.55218.9994c11h12n2o35-hydroxy-l-tryptophan0.013.2275.0208c10h16n2o5sbiotin sulfone0.015.283