药物分析专业词汇下载版.doc

药物分析专业词汇下载版药物分析专业词汇绪论释药系统（drug delivery system，DDS）中国药典（Chinese Pharmacopoeia,ChP）美国药典（The United States Pharmacopoeia,USP）美国国家处方集（The National Formulary,NF）英国药典（British Pharmacopoeia,BP）欧洲药典（European Pharmacopoeia,Ph.Eup）国际药典（The International Pharmacopoeia,Ph.Int）良好药品实验研究规范（Good Laboratory Practice,GLP）良好药品生产规范(Good Manufacture Practice,GMP)良好药品供应规范(Good Supply Practice,GSP)良好药品临床试验规范(Good Clinical Practice,GCP)分析质量管理(Analytical Quality Control,AQC)第1章 药物的鉴别试验药物的鉴别试验identification test一般鉴别试验general identification test专属鉴别试验specific identification test灵敏度sensitivity最低检出量minimum detectable quantity最低检出浓度minimum detectable concentration第2章 药物的杂质检查巯基醋酸mercaptoacetic acid古蔡Gutzeit二乙基二硫代氨基甲酸银siliver diethyldithio-carbamate硫酸灰分sulphated ash炽灼残渣residue on ignition热重分析法thermogravimetric analysis,TGA差示热分析法differential thermal analysis,DTA差示扫描量热法differential scanning calorimetry,DSC碱性酒石酸铜试验Fehlings reagent异红紫酸盐isopurpurate2，3-二氨基萘2,3-diaminonaphthalene4，5-苯并苯硒二唑4，5-benzopiazselenol第三章 定量分析样品前处理与测定方法的效能指标汞齐化法amalgamation method氧瓶燃烧法oxygen flask combustion method葡萄糖醛酸甙glucuronides硫酸酯sulphates血浆plasma血清serum全血whole blood治疗药物浓度监测therapeutic drug monitoring,TDM结合bound游离free缀合物conjugate液-液提取法liquid-liquid extraction,LLE离子对试剂ion pair reagent离子对提取法ion pair extraction method反离子counter液-固提取法liquid-solid extraction LSE半自动样品制备系统advanced automated sample processor,AASP烷基化alkylations酰基化acylations硅烷化silylations精密度precision标准差standard deviation,SD orS相对标准差relative standard deviation,RSD变异系数coefficient of variation,CV批内精密度within-run precision日内精密度within-day precision批间精密度between-run precision日间精密度day to day precision准确度accuracy定量限limit of quantitation,LOQ检测限limit of detection,LOD选择性selectivity专属性specificity线性与范围linearity and range重现性ruggedness耐用性robustness散布图scatter diagram荧光偏振免疫测定法fluorescence polarization immunoassay，FPIA第4章 巴比妥类药物的分析溴化十六烷基三甲基苄铵cetyltrimethylbenzylammonium bromide，CTMA氯化四癸基二甲基苄铵Tetradacyldimethybenzylammonium chloride，TDBA第5章 芳酸及其酯类药物的分析苯甲酸及其钠盐benzoic acid and sodium benzoate布美他尼bumetanide羟苯乙酯ethylparoben丙磺舒probenecid酚黄乙胺etamsylate第6章 胺类药物的分析第七章 杂环类药物的分析二硝基氯苯反应Vongerichten反应戊烯二醛反应K?nig反应第8章 生物碱类药物的分析生物碱alkaloids阿片gum opium扫尾剂tailing-suppressing reagent蒂巴因thebaine诺司卡品noscapine竞争离子competing ions亲脂性lipophicity拖尾因子tailing factor金刚烷adamantane第9章 维生素类药物的分析维生素vitamin去氢维生素A dehydroretinol去水维生素A anhydroretinol鲸醇kitol三氯化锑反应Carr-Price反应维生素B1 thiamine hydrochloride；盐酸硫胺2，3，5-三苯基氯化四氮唑 2，3，5-triphenyltetrazolium chlorid，TTC红四氮唑red tetrazoline，RT蓝四氮唑blue tetrazoline，BT3，3-二甲基氧苯基-双-4，4-（3，5-二苯基）氯化四氮唑3，3-dianisole-bis4，4-（3，5-dipheny）tetrazolium chloride有色甲 formazan铁-酚试剂iron-phenol reagent铁-柯柏试剂iron-Kober reagent第十一章 抗生素类药物的分析6-氨基青霉烷酸6-aminopenicillanic acid，6-APA7-氨基头孢菌烷酸7-aminocephalosporanic acid，7-ACA氨苄西林ampicillin5-甲基-3-邻氯苯基-4-异唑青霉素钠cloxacillin sodium羟氨苄青霉素amoxicillin氨基糖甙类抗生素aminoglycosides antibiotics链霉素streptomycin麦芽酚maltolN-甲基葡萄糖胺反应Elson-Morgan反应坂口反应 Sakaguchi反应庆大霉素gentamycin四环素类tetracyclines4-差向脱水四环素 4-ejpianhydrotetracycline，EATC第十二章 药物制剂分析 含量均匀度content uniformity溶出度dissulution离子对高效液相色谱法ion-pair，HPLC第十三章 生化药物分析概论 第十四章 中药制剂分析概论超临界流体萃取supercritical fluid extraction，SFE过弗罗里Florisil第十五章 药品质量标准的制定国际非专利药名International Names for Pharmaceutical Substances，INN去氧麻黄碱Metamfetaminum国际理论和应用化学联合会International Union of Pure and Applied Chemistry，IUPAC有机化学命名原则Nomenclature of Organic Chemistry可待因Codeinum地塞米松Dexamethasonum氯Chloroquinum青蒿素Artemisininum吗啡Morphinum苯扎溴铵Benzalkonii Bromidum1-（3，4-二羟苯基）-2-氨基乙醇重酒石酸盐一水合物1-（3，4-Dihydroxyphenyl）-2-Aminoethanol Bitartrate mono-hydrate第十六章 药品质量控制中的新方法与新技术填充柱packed column开管柱open tubular column空心柱capillary column熔融石英开管柱fused silica open tubular column，FSOT高分辨率气相色谱法high resolution gas chromatography，HRGC壁涂开管柱wall-coated open tubular column，WCOT柱固定化相开管柱immobilized phase open tubular column ，IPOT柱交联柱crosslinking column键合相柱bonding phase column不可提取相开管柱nonextractable phase open tubular column，NPOT柱多孔层开管柱porous-layer open tubular column，PLOT柱担体涂渍开管柱support-coated open tubular column，SCOT柱分流进样split injection不分流进样splitless injection柱头进样on-column injection直接进样direct injection手性分离色谱chiral separation chromatography，CSC普萘洛尔propranolol沙粒度胺thalidomide测定对映体enantiomer手性固定化chiralstationary phase，CSP手性衍生试剂chiral derivatization reagent，CDR非对映异构体diastereoisomer，DSTM配基交换型手性添加剂chiral ligand-exchange complexes，CLEC手性离子对络合剂chiralion pair complex，CIPC环糊精cyclodextrins，CD葡聚糖sephadex配基交换剂ligand exchanger手性传荷charge transfer（R）-N-3，5-二硝基苯甲酰苯基苷氨酸dimitrobenzyl phenylglycin；DNBPG三点手性识别模式three-point chiral recognition model噻吗洛尔thimolol曲洛磷胺trofosfamide乙酰葡萄糖异硫氰酸酯（2，3，4，6-tetra-O-acetyl-D-glucopyranosylisothiocyanate，GITC左旋比喹酮L-praziquantel比喹胺praziquanamine苯丙胺phenylpropamine异氰酸-萘酯（-naphthylisocyanae，NI美西律mexiletine氯胺酮ketamine本芴醇benflumelol苯丙醇phenyl propanol烯丙洛尔alprenolol普萘洛尔propranolol氧烯洛尔 oxyprenolol麻黄碱ephedrine毛细管电泳capillary electrophoresis，CE毛细管区带电泳capillary zone electrophoresis，CZE胶束动电毛细管色谱mcellar electrokinetic capillary chromatography，MECC胶束动电色谱miccellar electrokinetic chromatography，MEKC环糊精动电色谱cyclodextrins electrokinetic chromatography，CDEKC离子交换动电色谱ion-exchange electrokinetic chromatography，IEEKC微滴乳状液动电色谱microemulsion electrokinetic chromatography，MEEKC毛细管凝胶电泳capillary gel electrophoresis，CGE毛细管等电聚焦capillary isoelectric focusing，CIEF毛细管等速电泳capillary isotachorphoresis，CITP毛细管电色谱capillary electrochromatography ，CEC色谱响应函数chromatographic response function，CRF色谱优化函数chromatographic optimization function，COF等级色谱响应函数hierarchical chromatographic response function，HCRF差示分光光度法difference spectrophotometry近红外光谱near infra-red spectrum，NIRS中红外光谱mid infra-red spectrum，MIRS合谱combinations光谱匹配法spectral matching匹配指数match index，M.I.主成分分析法principal component regression，PCR人工神经网络方法artificial neural networks，ANN核磁共振nuclear magnetic resonance，NMR二维NMR two dimensional NMR六甲基三硅氧烷hexam ethylcyclotrisiloxane吡嗪pyrazine普鲁卡因procaine色谱联用技术hyphenated techniques chromatography，HTC接口interface重建色谱图reconstructive chromatogram命中质量系数hit quality index，HQI最小二乘方程序least squares algothm导数绝对值程序absolute derivative algothm导数平方程序square derivative algothm空心柱open tubular column，OTC总离子流total ion carrent，TIC选择性离子监测xelected ion monitoring，SIM多离子检测multiple ion detection，MID质量碎片图谱法mass fragmentography 冰片borneal川芎嗪tetram ethyloyrazine，TMP电子轰击离子化electron impact ionization，EI化学离子化chemical ionization，CI场解吸field desorption，EI快原子轰击fast atom bombardment，FAB热喷雾thermospray，TSP电喷雾electrospray，ESP大气压离子化atmospheric pressure ionization，API粒子束接口partical beam动态快原子轰击法FAB离子喷雾接口ISP电子喷雾法ESP大气压离子化接口API大气压化学电离APCI串联质谱MS-MS丽江山慈姑Iphigenia indica Kunth et Benth托非索泮tofisopam分析化学上册第一章 绪论分析化学：analytical chemistry定性分析：qualitative analysis定量分析：quantitative analysis物理分析：physical analysis物理化学分析：physico-chemical analysis仪器分析法：instrumental analysis流动注射分析法：flow injection analysis；FIA顺序注射分析法：sequentical injection analysis;SIA化学计量学：chemometrics第二章 误差的分析数据处理绝对误差：absolute error相对误差：relative error系统误差：systematic error可定误差：determinate error随机误差：accidental error不可定误差：indeterminate error准确度：accuracy精确度：precision偏差：debiation，d平均偏差：average debiation相对平均偏差：relative average debiation标准偏差（标准差）：standerd deviation;S相对平均偏差：relatibe standard deviation;RSD变异系数：coefficient of variation误差传递：propagation of error有效数字：significant figure置信水平：confidence level显著性水平：level of significance合并标准偏差（组合标准差）：pooled standard debiation舍弃商：rejection quotient ;Q 化学定量分析第三章 滴定分析概论滴定分析法：titrametric analysis滴定：titration容量分析法:volumetric analysis化学计量点：stoichiometric point等当点：equivalent point电荷平衡：charge balance电荷平衡式：charge balance equation质量平衡：mass balance物料平衡：material balance质量平衡式：mass balance equation第四章 酸碱滴定法酸碱滴定法：acid-base titrations质子自递反应：autoprotolysis reaction质子自递常数：autoprotolysis constant质子条件式:proton balance equation酸碱指示剂：acid-base indicator指示剂常数：indicator constant变色范围：colour change interval 混合指示剂：mixed indicator双指示剂滴定法：double indicator titration第五章 非水滴定法非水滴定法：nonaqueous titrations质子溶剂：protonic solvent 酸性溶剂：acid solvent 碱性溶剂：basic solvent 两性溶剂:amphototeric solvent 无质子溶剂：aprotic solvent 均化效应：differentiating effect区分性溶剂：differentiating solvent 离子化：ionization离解：dissociation结晶紫：crystal violet萘酚苯甲醇: -naphthalphenol benzyl alcohol奎哪啶红：quinadinered百里酚蓝：thymol blue偶氮紫：azo violet溴酚蓝：bromophenol blue第六章 配位滴定法配位滴定法：compleximetry乙二胺四乙酸：ethylenediamine tetraacetic acid,EDTA螯合物：chelate compound金属指示剂：metal lochrome indcator第七章 氧化还原滴定法氧化还原滴定法：oxidation-reduction titration碘量法：iodimetry溴量法：bromimetry 溴量法：bromine method铈量法：cerimetry高锰酸钾法：potassium permanganate method条件电位：conditional potential溴酸钾法：potassium bromate method硫酸铈法：cerium sulphate method偏高碘酸：metaperiodic acid高碘酸盐：periodate亚硝酸钠法：sodium nitrite method重氮化反应：diazotization reaction重氮化滴定法：diazotization titration亚硝基化反应：nitrozation reaction亚硝基化滴定法：nitrozation titration外指示剂：external indicator 外指示剂：outside indicator重铬酸钾法：potassium dichromate method第八章 沉淀滴定法沉淀滴定法：precipitation titration容量滴定法：volumetric precipitation method 银量法：argentometric method第九章 重量分析法重量分析法：gravimetric analysis挥发法：volatilization method引湿水（湿存水）：water of hydroscopicity包埋(藏)水：occluded water吸入水：water of imbibition结晶水：water of crystallization组成水：water of composition液-液萃取法：liquid-liquid extration 溶剂萃取法：solvent extration反萃取：counter extraction分配系数：partition coefficient分配比：distribution ratio离子对（离子缔合物）：ion pair沉淀形式：precipitation forms称量形式：weighing forms分析化学下册仪器分析 概述物理分析：physical analysis物理化学分析：physicochemical analysis仪器分析：instrumental analysis第十章 电位法及永停滴定法电化学分析：electrochemical analysis电解法：electrolytic analysis method电重量法：electtogravimetry库仑法：coulometry库仑滴定法：coulometric titration电导法：conductometry电导分析法：conductometric analysis电导滴定法：conductometric titration电位法：potentiometry直接电位法：dirext potentiometry电位滴定法：potentiometric titration伏安法：voltammetry极谱法：polarography溶出法：stripping method电流滴定法：amperometric titration化学双电层：chemical double layer相界电位：phase boundary potential金属电极电位：electrode potential化学电池：chemical cell液接界面：liquid junction boundary原电池：galvanic cell电解池：electrolytic cell负极：cathrode正极：anode电池电动势：eletromotive force指示电极：indicator electrode参比电极：reference electroade标准氢电极：standard hydrogen electrode一级参比电极：primary reference electrode饱和甘汞电极：standard calomel electrode银氯化银电极：silver silver-chloride electrode液接界面：liquid junction boundary不对称电位：asymmetry potential表观PH值：apparent PH复合PH电极：combination PH electrode离子选择电极：ion selective electrode敏感器：sensor晶体电极:crystalline electrodes均相膜电极：homogeneous membrance electrodes非均相膜电极：heterog eneous membrance electrodes非晶体电极：non- crystalline electrodes刚性基质电极：rigid matrix electrode流流体载动电极：electrode with a mobile carrier气敏电极：gas sensing electrodes酶电极：enzyme electrodes金属氧化物半导体场效应晶体管：MOSFET离子选择场效应管：ISFET总离子强度调节缓冲剂：total ion strength adjustment buffer,TISAB永停滴定法：dead-stop titration双电流滴定法（双安培滴定法）：double amperometric titration第十一章 光谱分析法概论普朗克常数：Plank constant电磁波谱：electromagnetic spectrum光谱：spectrum光谱分析法：spectroscopic analysis原子发射光谱法：atomic emission spectroscopy质量谱：mass spectrum质谱法：mass spectroscopy,MS第十二章 紫外可见分光光度法紫外可见分光光度法：ultraviolet and visible spectrophotometry;UV-vis肩峰：shoulder peak末端吸收：end absorbtion生色团：chromophore助色团：auxochrome红移：red shift长移：bathochromic shift短移：hypsochromic shift蓝（紫）移：blue shift增色效应（浓色效应）：hyperchromic effect减色效应（淡色效应）：hypochromic effect强带：strong band弱带：weak band吸收带：absorption band透光率：transmitance,T吸光度：absorbance谱带宽度：band width杂散光：stray light噪声：noise 暗噪声：dark noise散粒噪声：signal shot noise闪耀光栅：blazed grating全息光栅：holographic graaing光二极管阵列检测器：photodiode array detector偏最小二乘法：partial least squares method ,PLS褶合光谱法：convolution spectrometry褶合变换：convolution transform,CT离散小波变换：wavelet transform,WT多尺度细化分析：multiscale analysis供电子取代基：electron donating group吸电子取代基：electron with-drawing group第十三章 荧光分析法荧光：fluorescence荧光分析法：fluorometryX-射线荧光分析法：X-ray fulorometry原子荧光分析法：atomic fluorometry分子荧光分析法：molecular fluorometry振动弛豫：vibrational relexation内转换：internal conversion外转换：external conversion体系间跨越：intersystem crossing激发光谱：excitation spectrum荧光光谱：fluorescence spectrum斯托克斯位移：Stokes shift荧光寿命：fluorescence life time荧光效率：fluorescence efficiency荧光量子产率：fluorescence quantum yield荧光熄灭法：fluorescence quemching method散射光：scattering light瑞利光：Reyleith scanttering light拉曼光：Raman scattering light第十四章 红外分光光度法红外线：infrared ray,IR中红外吸收光谱：mid-infrared absorption spectrum,Mid-IR远红外光谱：Far-IR微波谱：microwave spectrum,MV红外吸收光谱法：infrared spectroscopy红外分光光度法：infrared spectrophotometry振动形式：mode of vibration伸缩振动：stretching vibration对称伸缩振动：symmetrical stretching vibration不对称伸缩振动：asymmetrical stretching vibration弯曲振动：bending vibration变形振动：formation vibration面内弯曲振动:in-plane bending vibration,剪式振动：scissoring vibration,面内摇摆振动：rocking vibration,面外弯曲振动：out-of-plane bending vibration,面外摇摆振动：wagging vibration,蜷曲振动：twisting vibration ,对称变形振动：symmetrical deformation vibration ,s不对称变形振动：asymmetrical deformation vibration, as特征吸收峰:charateristic avsorption band特征频率：characteristic frequency相关吸收峰：correlation absorption band杂化影响：hybridization affect环大小效应：ring size effect吸收峰的强度：intensity of absorption band环折叠振动：ring prckering vibration第十五章 原子吸收分光光度法原子光谱法：atomic spectroscopy原子吸收分光光度法：atomic absorption spectrophotometry,AAS原子发射分光光度法：atomic emmsion spectrophotometry,AES原子荧光分光光度法：atomic fluorescence spectrophotometry,AFS第十六章 核磁共振波谱法核磁共振：nuclear magnetic resonance,NMR核磁共振波谱：NMR spectrum核磁共振波谱法：NMR spectroscopy扫场：swept field扫频：seept frequency连续波核磁共振：continuous wave NMR,CW NMRFourier变换NMR：PFT-NMR,FT-NMR二维核磁共振谱：2D-NMR质子核磁共振谱：proton magnetic resonance spectrum,PMR氢谱：1H-NMR碳13核磁共振谱：13C-NMR spectrum,13CNMR自旋角动量：spin angular momentum磁旋比：magnetogyric ratio磁量子数：magnetic quantum number,m进动：precession弛豫历程：relaxation mechanism局部抗磁屏蔽：local diamagnetic shielding屏蔽常数：shielding constant化学位移：chemical shift国际纯粹与应用化学协会：IUPAC磁各向异性：magnetic anisotropy远程屏蔽效应：long range shielding effect结面：nodal plane自旋自旋偶合：spin-spin coupling自旋自旋分裂：spin=spin splitting单峰：singlet,s双峰：doublet,d三重峰：triplet,t四重峰：quartet五重峰：quintet六重峰：sextet偕偶：geminal coupling邻偶：vicinal coupling远程偶合：long range coupling磁等价：magnetic eqivalence自旋系统：spin system一级光谱：first order spectrum二级光谱（二级图谱）：second order spectrumC-H光谱：C-H correlated spectroscopy,C-H COSY第十七章 质谱法质谱分析法：mass spectrometry质谱：mass spectrum,MS棒图：bar graph选择离子检测：selected ion monitoring ,SIM直接进样：direct probe inlet ,DPI接口：interface气相色谱质谱联用：gas chromatography-mass spectrometry,GC-MS高效液相色谱质谱联用：high performance liquid chromatography-mass spectrometry,HPLC-MS电子轰击离子源：electron impact source,EI离子峰：quasi-molecular ions化学离子源：chemical ionization source,CI场电离：field ionization,FI场解析：field desorptiion,FD快速原子轰击离子源：fast stom bombardment ,FAB质量分析器：mass analyzer磁质谱仪：magnetic-sector mass spectrometer四极杆质谱仪（四极质谱仪）：quadrupole mass spectrometer原子质量单位:amu离子丰度：ion abundance相对丰度(相对强度)：relative avundance基峰：base peak质量范围：mass range分辨率：resolution灵敏度：sensitivity信噪比：S/N分子离子：molecular ion碎片离子：fragment ion同位素离子：isotopic ion亚稳离子：metastable ion亚稳峰：metastable peak母离子：paren ion子离子：daughter含奇数个电子的离子：odd electron含偶数个电子的离子：even eletron,EE均裂：homolytic cleavage异裂（非均裂）：heterolytic cleavage半均裂：hemi-homolysis cleavage重排：rearragement分子量：MW裂解：-cleavage第十八章 色谱分析法概论色谱法（层析法）：chromatography固定相：stationary phase流动相：mobile phase超临界流体色谱法：SFC高效毛细管电泳法：high performance capillary electroporesis,HPEC气相色谱法：gas chromatography,GC液相色谱法：liquid cromatography,LC超临界流体色谱法：supercritical fluid chromatography,SFC气-固色谱法：GSC气-液色谱法：GLC液-固色谱法：LSC液-液色谱法：LLC柱色谱法：column chromatography填充柱：packed column毛细管柱：capillary column微填充柱：icrobore packed column高效液相色谱法：high performance liquid chromatography,HPLC平板色谱法：planar平板色谱法：plane chromatography纸色谱法：paper chromatography薄层色谱法：thin layer chromatography,TLC薄膜色谱法;thiin film chomatography毛细管电泳法：capillary electrophoresis,CE分配色谱法：partition chromatography吸附色谱法：adsorpion chromaography离子交换色谱法：ion exchange chromatography,IEC空间排阻色谱法：steric exclusion chromatography,SEC亲和色谱法：affinity chromatography分配系数：distribution cofficient狭义分配系数：partition coefficient凝胶色谱法：gel chromatography凝胶渗透色谱法：gel permeation chromatography,GPC凝胶过滤色谱法：gel filtration chromatography,GFC渗透系数：permeation coefficien;Kp化学键合相色谱法：chemically bonded-phase chromatography分配系数：distribution coefficient靛菁绿：indocyanine气相色谱傅立叶变换红外光谱：GC-FTIR第十九章 经典液相色谱法薄层色谱法：TLC吸附：adsorption活化：activation脱活性：deactivation交联度：degree of cross linking交换容量：exchange capacity薄层板：thin layer plate展开剂：developing solvent ,developer临界胶束浓度：criticak micolle concentration ,CMC相对比移值：relative Rf, Rr分离度：resolution ,R分离数：separation number,SN煅石膏：Gypsum羧甲基纤维素钠：CMC-Na吸收光谱联用：TLC-UV薄层色谱荧光联用：TLC-F薄层色谱红外吸收光谱联用：TLC-IR薄层色谱法：TLC-MS纸色谱法：paper chromatography上行展开：ascending development 下行法展开：descending development双向展开：two dimensional develoooment第二十章 气相色谱法气相色谱法：gas chromatography前延峰：leading peak拖尾峰：tailing peak对称因子：symmetry factor,fs保留时间：retention time保留体积：retention volume死时间：dead time调整保留时间：asjusted retention time半峰宽：peak width at half height,W1/2 or Y1/2峰宽：peak width,W等温线：isotherm理论塔板高度：height equivalent to atheoretical plate化学键合相：chemically bonded phase丁二酸二乙