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Selected references C H activation reviews 1 Bergman R G Organometallic chemistry C H activation Nature 2007 446 391 393 2 Godula K Sames D C H Bond Functionalization in Complex Organic Synthesis Science 2006 312 67 72 3 Labinger J A Bercaw J E Understanding and exploiting C H bond activation Nature 2002 417 507 514 4 Jia C Kitamura T Fujiwara Y Catalytic Functionalization of Arenes and Alkanes via C H Bond Activation Acc Chem Res 2001 34 633 639 5 Stahl S S Labinger J A Bercaw J E Homogeneous Oxidation of Alkanes by Electrophilic Late Transition Metals Angew Chem Int Ed 1998 37 2180 2192 6 Shilov A E Shul pin G B Activation of C H Bonds by Metal Complexes Chem Rev 1997 97 2879 2932 Rh carbenoid C H insertion reviews 1 Davies H M L Manning J R Catalytic C H functionalization by metal carbenoid and nitrenoid insertion Nature 2008 451 417 424 2 Davies H M L Recent Advances in Catalytic Enantioselective Intermolecular C H Functionalization13 Angew Chem Int Ed 2006 45 6422 6425 3 Pedro M P G Afonso C A M Stereo and Regiocontrol in the Formation of Lactams by Rhodium Carbenoid C H Insertion of alpha Diazoacetamides Eur J Org Chem 2004 2004 3773 3788 4 Davies H M L Beckwith R E J Catalytic Enantioselective C H Activation by Means of Metal Carbenoid Induced C H Insertion Chem Rev 2003 103 2861 2904 5 Doyle M P Forbes D C Recent Advances in Asymmetric Catalytic Metal Carbene Transformations Chem Rev 1998 98 911 936 6 Padwa A Austin D J Ligand Effects on the Chemoselectivity of Transition Metal Catalyzed Reactions of alpha Diazo Carbonyl Compounds Angew Chem Int Ed 1994 33 1797 1815 7 Doyle M P Electrophilic metal carbenes as reaction intermediates in catalytic reactions Acc Chem Res 1986 19 348 356 Mechanistic studies 1 Pirrung M C Liu H Morehead A T Rhodium Chemzymes Michaelis Menten Kinetics in Dirhodium II Carboxylate Catalyzed Carbenoid Reactions J Am Chem Soc 2002 124 1014 1023 2 Nakamura E Yoshikai N Yamanaka M Mechanism of C H Bond Activation C C Bond Formation Reaction between Diazo Compound and Alkane Catalyzed by Dirhodium Tetracarboxylate J Am Chem Soc 2002 124 7181 7192 3 Snyder J P Padwa A Stengel T Arduengo A J Jockisch A Kim H J A Stable Dirhodium Tetracarboxylate Carbenoid Crystal Structure Bonding Analysis and Catalysis J Am Chem Soc 2001 123 11318 11319 4 Crabtree R The Organometallic Chemistry of the Transition Metals 2001 5 Dorwald F Z Metal Carbenes in Organic Synthesis 1999 6 Taber D F You K K Rheingold A L Predicting the Diastereoselectivity of Rh Mediated Intramolecular C H Insertion J Am Chem Soc 1996 118 547 556 7 Pirrung M C Morehead A T Saturation Kinetics in Dirhodium II Carboxylate Catalyzed Decompositions of Diazo Compounds J Am Chem Soc 1996 118 8162 8163 8 Wang P Adams J Model Studies of the Stereoelectronic Effect in Rh II Mediated Carbenoid C H Insertion Reactions J Am Chem Soc 1994 116 3296 3305 9 Doyle M P Westrum L J Wolthuis W N E See M M Boone W P Bagheri V Pearson M M Electronic and steric control in carbon hydrogen insertion reactions of diazoacetoacetates catalyzed by dirhodium II carboxylates and carboxamides J Am Chem Soc 1993 115 958 964 10 Trost B M Fleming I In Comprehensive Organic Synthesis Selectivity Strategy and Efficiency in Modern Organic Chemistry Elsevier 1991 Vol 3 p 1048 11 Alonso M E Garcia M d C Kinetics of the dirhodium tetraacetate catalyzed decomposition of ethyl diazoacetate in 1 4 dioxane Is nitrogen involved in the transition state Tetrahedron 1989 45 69 76 12 Fleming I Frontier Orbitals and Organic Chemical Reactions 1976 Reactions and synthesis 1 Nicolaou K C Stepan A F Lister T Li A Montero A Tria G S Turner C I Tang Y Wang J Denton R M Edmonds D J Design Synthesis and Biological Evaluation of Platensimycin Analogues with Varying Degrees of Molecular Complexity J Am Chem Soc 2008 130 13110 13119 2 Thu H Y Tong G S M Huang J S Chan S L F Deng Q H Che C M Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary CH Bonds and Enantioselective CC Bond Formation13 Angew Chem Int Ed 2008 47 9747 9751 3 Nicolaou K C Lister T Denton R M Montero A Edmonds D J Adamantaplatensimycin A Bioactive Analogue of Platensimycin13 Angew Chem Int Ed 2007 46 4712 4714 4 Davies H M L Manning J R C H Activation as a Strategic Reaction Enantioselective Synthesis of 4 Substituted Indoles J Am Chem Soc 2006 128 1060 1061 5 Davies H M L Dai X Long M S Combined C H Activation Cope Rearrangement as a Strategic Reaction in Organic Synthesis Total Synthesis of Colombiasin A and Elisapterosin B J Am Chem Soc 2006 128 2485 2490 6 Yoshikai N Nakamura E Theoretical Studies on Diastereo and Enantioselective Rhodium Catalyzed Cyclization of Diazo Compound via Intramolecular C H Bond Insertion Adv Synth Catal 2003 345 1159 1171 7 Kurosawa W Kan T Fukuyama T Stereocontrolled Total Synthesis of Ephedradine A Orantine J Am Chem Soc 2003 125 8112 8113 8 Davies H M L Venkataramani C Hansen T Hopper D W New Strategic Reactions for Organic Synthesis Catalytic Asymmetric C H Activation to Nitrogen as a Surrogate for the Mannich Reaction J Am Chem Soc 2003 125 6462 6468 9 Davies H M L Beckwith R E J Antoulinakis E G Jin Q New Strategic Reactions for Organic Synthesis Catalytic Asymmetric C H Activation to Oxygen as a Surrogate to the Aldol Reaction J Org Chem 2003 68 6126 6132 10 Davies H M L Venkataramani C Catalytic Enantioselective Synthesis of 2 Amino Acids13 Angew Chem Int Ed 2002 41 2197 2199 11 Yoon C H Zaworotko M J Moulton B Jung K W Regio and Stereocontrol Elements in Rh II Catalyzed Intramolecular C H Insertion of Diazo phenylsulfonyl acetamides Org Lett 2001 3 3539 3542 12 Davies H M L Ren P Jin Q Catalytic Asymmetric Allylic C H Activation as a Surrogate of the Asymmetric Claisen Rearrangement Org Lett 2001 3 3587 3590 13 Davies H M L Hansen T Churchill M R Catalytic Asymmetric C H Activation of Alkanes and Tetrahydrofuran J Am Chem Soc 2000 122 3063 3070 14 Davies H M L Antoulinakis E G Hansen T Catalytic Asymmetric Synthesis of Syn Aldol Products from Intermolecular C H Insertions between Allyl Silyl Ethers and Methyl Aryldiazoacetates Org Lett 1999 1 383 386 15 Taber D F Malcolm S C Rhodium Mediated Intramolecular C H Insertion Probing the Geometry of the Transition State J Org Chem 1998 63 3717 3721 16 Davies H M L Hansen T Asymmetric Intermolecular Carbenoid C H Insertions Catalyzed by Rhodium II S N p Dodecylphenyl sulfonylprolinate J Am Chem Soc 1997 119 9075 9076 17 Taber D F You K K Rheingold A L Predicting the Diastereoselectivity of Rh Mediated Intramolecular CH Insertion J Am Chem Soc 1996 118 547 556 18 Ye T McKervey M A Organic Synthesis with alpha Diazo Carbonyl Compounds Chem Rev 1994 94 1091 1160 19 Hashimoto S J Watanabe N Ikegami S Enantioselective Intramolecular C H Insertion Reactions of Diazo Keto Esters Catalyzed by Dirhodium II Tetrakis N phthaloyl S phenylalaninate The Effect of the Substituent at the Insertion Site on Enantioselectivity Synlett 1994 1994 353 355 20 Brown D S Elliott M C Moody C J Mowlem T J Marino J P J Padwa A Ligand Effects in the Rhodium II Catalyzed Reactions of alpha Diazoamides Oxindole Formation is Promoted by the Use of Rhodium II Perfluorocarboxamide Catalysts J Org Chem 1994 59 2447 2455 21 Padwa A Austin D J Price A T Semones M A Doyle M P Protopopova M N Winchester W R Tran A Ligand effects on dirhodium II carbene reactivities Highly effective switching between competitive carbenoid transformations J Am Chem Soc 1993 115 8669 8680 22 Doyle M P Westrum L J Wolthuis W N E See M M Boone W P Bagheri V Pearson M M Electronic and steric control in carbon hydrogen insertion reactions of diazoacetoacetates catalyzed by dirhodium II carboxylates and carboxamides J Am Chem Soc 1993 115 958 964 23 Padwa A Austin D J Hornbuckle S F Semones M A Doyle M P Protopopova M N Control of chemoselectivity in catalytic

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