急性髓细胞白血病治疗新进展

acute myelocytic leukemia aml 70 4 6 10 2004 10000 7100 70 20 1 1 1 1 aml 3 flt3 2 70 100 aml flt3 30 50 aml flt3 flt3 aml flt3 flt3 cep 2701 mln 518 pkc 412 su 25416 su 25416 12 aml 6 cr cr su 25416 cr 10 2002 30 40 aml flt3 flt3 flt3 aml aml cr 1 2 ft ras 15 25 aml ras ras ft ras r sch 66336 bns aml cml m ds r ft 3 1 3 cd33 cd33 3912 kd 90 aml cd33 cd33 cd33 calicheamin aml mylotarg 4 5 mylotarg 142 cd33 aml 30 42 142 16 23 142 cr 519 mylotarg aml mylotarg 39 aml cr 46 8 6 cd33 1 4 bcl 2 bcl 2 b b cell lymphoma leukemia 2 bcl 2 bcl 2 t 14 18 bcl 2 18q21 14q32 igh bcl 2 bcl 2 g3139 7 bcl 2 g3139 bcl 2 bcl 2 abt 737 bcl 2 andreeff abt 737 aml aml aml mc l 1 abt 737 mcl 1 bcl 2 mcl 1 1 5 tribbles aml tribbles tribbles aml tribbles 2 trib 2 aml aml c ebpa trib 2 aml tribbles tribb les tribbles aml c ebp a tribbles 2 c ebpa tribbles 2 8 1 6 rig g rig g nb4 60 kd atra rig retinoic acid induced gene e rig g 8 atra rig a b c d h j k l rig k atra 8 h actinine atra apl 9 rig g u 937 rig g g1 s rig g j ab1 jab1 p27 jab1 p27 rig g c myc c myc p21 p21 ifn atra rig g atra ifn 10 2 2 1 multidrug resistance mdr p gp mdr1 p gp 35 17 35 50 27 11 50 39 56 68 68 71 12 mdr1 p gp cr 13 17 ps c 833 valspodar p gp 6 psc 833 valspodar bronno van der holt knauf 18 psc 833 60 60 aml cr 2 2 a all trans retinoic acid atra as2o3 1986 atra apl 24 23 apl atra cr 90 95 19 apl cr as2o3 as2o3 apl atra apl 20 21 23 as2o3 nb4 apl apl as2o3