细胞周期和细胞凋亡类基因

1、细胞周期和细胞凋亡类基因G0 G1 转变 (G0 to G1 transition) 1: mdm4G1/S 特异转录，有丝分裂细胞周期 (G1/S-specific transcription in mitotic cell cycle) 1: gfi1G1/S 转变 , 有丝分裂细胞周期 (G1/S transition of mitotic cell cycle) 19: bcat1 ccnd1 ccne1 cdc34 cdc7 cdca5 cdk4 cdkn3 cul1 cul2 cul3 cul4a cul5 gspt1 lats2 pml ppp6c rcc1 skp2G1/S 转

2、变检控点 (G1/S transition checkpoint) 4: dlg1 hus1 nbn puraG1 期 (G1 phase) 2: cdc42 rb1G1 期, 有丝分裂细胞周期 (G1 phase of mitotic cell cycle) 10: anapc2 cdc23 cdk6 cdkn1c dnaja2 e2f1 map3k11 taf1 taf1l tbrg4G1 特异转录，有丝分裂细胞周期 (G1-specific transcription in mitotic cell cycle) 1: gfi1bG2/M 转变 , 有丝分裂细胞周期 (G2/M tran

3、sition of mitotic cell cycle) 10: anapc10 anapc4 anapc5 birc5 ccnb1 cdk2 dnm2 khdrbs1 lats1 tpd52l1G2/M 转变 DNA 损伤检控点 (G2/M transition DNA damage check-point) 1: brsk1G2 期 , 有丝分裂细胞周期 (G2 phase of mitotic cell cycle) 4: cenpf ches1 gtse1 kpna2M 期 (M phase) 2: ilf3 rb1M 期, 有丝分裂细胞周期 (M phase of mitotic

4、cell cycle) 4: cdc25b dlg7 mphosph6 mphosph9M 期特异微管过程 (M phase specific microtubule process) 1: kpna2S-M 检控点 (S-M checkpoint) 1: appbp1S 期 , 有丝分裂细胞周期 (S phase of mitotic cell cycle) 1: cdk2ap1S 期特异转录，有丝分裂细胞周期 (S-phase-specific transcription in mitotic cell cycle) 1: abl1胞裂蛋白环组装 (septin ring assembly

5、) 1: nubp1胞质分裂 (cytokinesis) 16: arhgef11 aurkc cecr2 dctn3 diaph2 espl1 myh10 prc1 rasa1 rock2 sept2 sept3 sept4 sept5 sept6 sept7不对称细胞分裂 (asymmetric cell division) 1: pard3凋亡程序 (apoptotic program) 10: bad bik casp2 casp7 casp8 casp9 mcl1 pdia2 psen2 vda c1 凋亡核改变 (apoptotic nuclear changes) 2: dedd

6、2 ndufa13凋亡染色体浓缩 (apoptotic chromosome condensation) 1: acin1凋亡线粒体改变 (apoptotic mitochondrial changes) 4: bak1 bax bcl2l1 bid 动粒组装 (kinetochore assembly) 2: cenpe cenpf 纺锤体组织和生物发生 (spindle organization and biogenesis) 7: aurka bub1b cks2 kntc2 spag5 ube2c zwint分裂间期 , 有丝分裂细胞周期 (interphase of mitotic

7、cell cycle) 1: katna1 减数分裂 (meiosis) 30: boll c8orf1 ccna1 ccnb3 cspg6 dmc1 dmwd dusp13 exo1 h2afx mre11a msh4 msh5 nek2 rad50 rad51 rad54l rec8l1 smc1l1 smc1l2 spo11 stag2 stag3 sycp1 sycp2 top3a tsga2 utp14c xrcc2 zw10 减数分裂纺锤体组织和生物发生 (meiotic spindle organization and biogenesis) 1: tubg1 减数分裂前期 I

8、(meiotic prophase I) 1: sycp2 减数分裂前期 II (meiotic prophase II) 1: msh5 减数分裂染色体凝集 (meiotic chromosome segregation) 1: sgol1减数分裂重 组 (meiotic recombination) 19: atm chek1 dmc1 klhdc3 lig3 mlh3 mre11a msh4 msh5 rad21 rad50 rad51 rad51l1 rad51l3 rad52 rad54b rec8l1 spo11 sycp1 姐妹染色单体凝集 (sister chromatid s

9、egregation) 1: lats1 姐妹染色单体连接 (sister chromatid cohesion) 3: cspg6 pols rec8l1 跨越开始控制点 , 有丝分裂细胞周期 (traversing start control point of mitotic cell cycle) 6: cdc2 cdc25c cdc6 cdc7 cdk10 cdk2联会复合体形成 (synaptonemal complex formation) 4: sc65 stag3 sycp1 sycp2内 S DNA 损伤检控点 (intra-S DNA damage checkpoint)

10、1: nek11 确立有丝分裂纺锤体定位 (establishment of mitotic spindle localiz-ation) 1: espl1 确立有丝分裂纺锤体取向 (establishment of mitotic spindle orient-ation) 1: pafah1b1 染色体凝集 (chromosome segregation) 13: espl1 psen1 psen2 pttg1 rad21 riok3 sgol2 smc1l1 smc1l2 srpk1 stag1 stag2 stag3染色体浓缩 (chromosome condensation) 1:

11、hils1 染色体组织和生物发 生 (chromosome organization and biogenesis) 8: pttg1 pttg3 rad50 smc1l1 smc1l2 smc2l1 smc5l1 smchd1染色体组织和生物发生 (见于真核生物 ) (chromosome organization and biogenesis (sensu Eukaryota) 82: abtb2 ard1a atrx cbx4 cenpa chd1 chd2 chd3 chd4 cspg6 egf h1f0 h1fx h2afb1 h2afb3 h2afv h2 afx h2afy h2

12、afy2 h2afz h2bfm h2bfs h3f3a h3f3b hist1h1b hist1h1c hist1h1d hist1 h1e hist1h2ab hist1h2ac hist1h2ae hist1h2ag hist1h2ak hist1h2aps4 hist1h2ba hist 1h2bb hist1h2bc hist1h2bd hist1h2bh hist1h2bj hist1h2bk hist1h2bl hist1h2bm hi st1h2bn hist1h2bo hist1h3f hist1h4g hist2h2aa hist2h2ac hist2h2bc hist2h

13、2be hist 2h3c hist3h2bb hist3h3 hmga1 hmga2 loc340096 loc340549 loc347376 loc388177 loc391405 loc391769 loc391770 loc442461 loc653604 prm1 prm2 psen1 psen2 ra d21 rad21l1 rec8l1 rp11-196g18.6 rp5-998n21.6 smc4l1 tnfrsf7 tnp1 tnp2 top3a to p3b twist1 znf238细胞成熟 (cell maturation) 1: il21细胞凋亡 (apoptosi

14、s) 262: acin1 ad7c-ntp adora2a adra1a agtr2 ahr akt1 api5 aplp1 app a pr-2 arhgef6 atg12 atg5 aven axin1 axud1 bag1 bag2 bag3 bag4 bag5 bax bbc3 b cap29 bcap31 bcl2l11 bcl2l12 bfar birc1 birc4 birc5 birc6 birc7 bmf bnip1 bnip2 bn ip3l bnipl bre c12orf22 casp14 casp3 casp6 casp8ap2 cd14 cd40 cd5l cdc

15、2l1 cdc2l 2 cdkn2a cgb7 ciapin1 cias1 cidea cideb cidec clu crop cse1l ctnnal1 ctnnbl1 cycs dad1 dap dap3 dapk1 dapk2 dapk3 daxx dcc ddx41 dffa dffb dhcr24 diablo dido1 dnase1 dnase1l3 dnase2 dock1 dpf2 e2f1 eaf2 ebag9 edar egln3 eif2ak2 elmo1 el mo2 elmo3 ep300 ern1 ern2 espl1 f2 f2r faf1 faim faim

16、2 fas faslg fastk fis1 fksg2 fl j21901 foxo3a fxr1 gadd45a gadd45b gadd45g gas2 glrx2 gml gpr65 gzma gzmb gzmh hd hipk2 hipk3 htra2 iapp ier3 ihpk3 il17 il19 il1a il1b il24 il2ra ing4 itgb2 itg b3bp kcnip3 kiaa0971 kiaa1967 lgals12 lgals7 litaf ltbr ly86 maea mageh1 magi3 map3k5 mdm4 moap1 mrps30 mt

17、p18 nalp2 nckap1 ndufa13 nfkb1 nfkbia ngfr ng frap1 nme3 nme6 ntn1 p2rx1 pak1 pawr pax3 pdcd1 pdcd10 pdcd11 pdcd2 pdcd4 pdcd6 pdcd6ip pdcd7 pdcd8 pdcl3 pde1b phlda1 phlpp pml ppard ppm1f ppp1r 13b ppp1r13l ppp1r15a ptk2b ptpn6 ptrh2 pura purb rad21 raf1 rffl ripk1 ripk3 rnf 130 rnf34 rock1 rybp scar

18、b1 sema6a sgk sgpl1 sh3glb1 siah1 siah2 sirt1 siva slc25 a6 smndc1 spata4 spin2 sqstm1 stk17a stk17b stk3 stk4 sulf1 taip-2 taok2 tbrg4 te gt tesk2 tia1 tiaf1 tial1 tnf tnfaip3 tnfrsf10a tnfrsf10c tnfrsf10d tnfrsf11b tnfrsf12a t nfrsf14 tnfrsf19 tnfrsf1a tnfrsf1b tnfrsf21 tnfrsf25 tnfrsf6b tnfrsf7 t

19、nfsf10 tnfsf12 tn fsf7 tnfsf9 tp53 tp53bp2 tp53inp1 tp73 tp73l tradd triad3 trib3 trim35 txnl1 ube4b unc5a unc5b unc5c unc5d yars zbtb16 zdhhc16 znf346细胞分裂 (cell division) 138: als2cr19 anapc1 anapc10 anapc11 anapc2 anapc4 anapc5 an apc7 aspm bcar1 brrn1 bub1 bub1b ccdc16 ccdc5 ccna1 ccna2 ccnb1 ccn

20、b2 ccnb3 ccnc ccnd1 ccnd2 ccnd3 ccne1 ccne2 ccnf ccng1 ccng2 ccnk ccnt1 ccnt2 ccrk cdc1 4a cdc16 cdc2 cdc20 cdc23 cdc25a cdc25b cdc25c cdc2l2 cdc2l6 cdc40 cdc42 cdc6 cdc7 cdca1 cdca5 cdca8 cdk2 cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 cenpe cenpf cenpj cetn1 cetn2 cetn3 chfr cit cks1b cks2 clasp1 clasp2 cnap1

21、cntrob cspg6 dclre1a flj3 7927 ftsj3 fzr1 hcap-g incenp katna1 katnb1 kif11 kif23 kntc1 lats1 lats2 lig1 lig3 li g4 mad1l1 mad2l1 mad2l2 mapre1 mapre2 mapre3 nedd9 nek1 nek2 nek3 nek4 n ek9 nudc pafah1b1 papd5 pard6a pard6b pard6g pols ppp1ca ppp1cb ppp1cc ptt g1 rad21 rcc1 rcc2 sept1 sept10 sept11

22、sgol1 sgol2 sirt2 smc1l1 smc2l1 smc4l1 sp ag5 spata5l1 sssca1 stag1 stag2 sycp1 sycp2 tacc1 terf1 txnl4a ube2c wee1 zc3hc1 znf367 zw10细胞溶解 (cytolysis) 15: c5 c6 c7 c8a c8b c8g c9 gzma gzmb gzmh gzmm lyz mmd mmd2 prf1细胞生长 (cell growth) 31: ar csrp2 ddx5 dgkd emp1 emp3 erbb2ip esr1 fgf20 fgfr1 fgfr2 f

23、 gfr3 fhl1 frap1 klf6 lefty1 lefty2 loc440836 ltbp4 mtpn ndrg4 nop5/nop58 notch2 p8 slc3a2 tgfb1 tgfb2 tgfb3 tnn vat1 xrn2细胞死亡 (cell death) 22: aplp1 aptx bnip3 clu clul1 dbc1 eif4g2 emp1 emp2 emp3 faf1 fo sl2 il17 ins nup62 parp4 psmc5 ptger3 setx tgfb1 tgfb2 zak细胞增殖 (cell proliferation) 253: ache

24、adra1b adra1d akr1c3 appl ar areg arhgef1 bcar1 b cat1 bhlhb3 bin1 blzf1 bst2 btc bub1 bub1b bub3 c2orf29 cbfa2t2 cbfa2t3 cckbr c d160 cd5 cd74 cdc14a cdc16 cdc25a cdc25c cdc27 cdc2l1 cdk3 cdk4 cdk5 cdk5r1 cdk5rap1 cdk5rap3 cdk6 cdk7 cdk9 cenpf chgn chrm1 chrm3 chrm4 chrm5 cklf cks2 clk1 col4a3 creg

25、1 crip1 cse1l csf1 csf1r csrp2 ctf1 ctnnbip1 cul5 cxcl1 cyr61 dab2 dctn2 dip13b dkc1 dlg7 dtymk e2f1 e4f1 edd1 ednra egfr eln emp1 emp2 enpep ephb4 eps15 eps8 erbb2 erbb4 erf erg evi5 fes fgf1 fgf2 fgf3 fgf4 fgf5 fgf6 fgf7 fgf8 fgf9 figf frat2 fscn1 fth1 fzd3 gab1 gas6 gcg gfer gfi1b gkn1 gpc4 grn g

26、rpr hdgf hdgfrp3 ifi16 ifrd2 igf2 igfbp4 igsf8 il15ra il1a il1b il2ra il5ra il6r il8rb il9r ilk-2 insig1 insl4 irf2 isg20 khdrbs1 kif2c kitlg klf10 krt16 lgi1 lmo1 lrp1 lrpap1 ly86 map3k11 mapre1 mapre2 mas1 matk mdk mdm4 met mia mif mki67 mnat1 mpl ms4a2 m t3 mtcp1 mxd1 myc myt2 nab2 ndp npy nr6a1

27、nrd1 osm osmr pa2g4 pcna pdap1 pdgfa pdgfb pdgfra pemt pes1 pgf pim1 pim2 plk1 ppard ppbp prdm4 prdx1 prg4 prkd1 prl prmt5 prok1 prok2 psphl ptch pten ptn pura purb pyy raf1 rapgef3 rb bp7 reg1b reg3a retnlb rfp rps27 runx3 s100a6 s100b serpinf1 sfn shfm3p1 sipa1 s kp2 slc29a2 sphk2 spock1 stil syk

28、tacstd2 tal1 tcf19 tcf8 tfdp1 tgfa tgfb1 tgfb2 tgf b3 tgfbi thpo tnfrsf17 tnfsf13b tnfsf7 tnfsf8 tnfsf9 tp53 tpd52l2 tpx2 traip tspan1 t span2 tspan3 tspy1 tusc2 txlna txn txndc ube2v2 usp8 vegf vegfb vegfc vti1b wit1 zak zfp36l2 zmynd11 znf259细胞周期 (cell cycle) 354: ahr als2cr19 anapc1 anapc10 anapc

29、11 anapc2 anapc4 anapc5 a napc7 ankrd15 apc appbp1 appl aspm atm atr aurka aurkb aurkc axin1 bax bcl10 bin1 bin3 brca1 brms1 bub1 bub1b c10orf46 c13orf10 c6orf88 ccdc16 ccdc5 ccna 1 ccna2 ccnb1 ccnb2 ccnb3 ccnc ccnd1 ccnd2 ccnd3 ccne1 ccne2 ccnf ccng1 ccng 2 ccnh ccnk ccnt1 ccnt2 ccrk cdc14a cdc16 c

30、dc2 cdc20 cdc23 cdc25a cdc25c cdc2l 1 cdc2l2 cdc42 cdc45l cdc5l cdc6 cdc7 cdc73 cdca5 cdk2 cdk2ap1 cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 cdkn1a cdkn1b cdkn1c cdkn2a cdkn2b cdkn2c cdkn2d cdkn3 cdt1 cenpe cetn1 cetn2 cgref1 cgrrf1 chaf1a chaf1b chek1 chek2 chfr cit cks1b cks2 cla sp1 clasp2 clspn cnap1 cntrob

31、 cspg6 ctcf ctcfl cul1 cul2 cul3 cul4a cul4b cul5 cul7 cyld dbc1 dcc dclre1a ddit3 ddx11 dip13b dlec1 dlg7 dmbt1 dmc1 dtymk dusp1 e 2f1 e2f2 e2f3 e2f4 e2f6 egfr eif2ak2 ep300 erbb2ip esco1 esco2 ext1 ext2 fancd2 f h fhit flcn flj37927 flj44060 fzr1 g0s2 gadd45a gak gas1 gas2 gmnn gps1 gps2 grlf 1 gs

32、g2 h2afx hcap-g hcfc1 hdac4 hdac6 hic1 hmg20b hrasls3 hsmpp8 htatip2 ince np ing1 ing4 irf1 jag2 katna1 katnb1 khdrbs1 kif11 kif23 klk10 kntc1 kntc2 lats1 lat s2 lig1 lig3 lig4 loc644162 loh11cr2a lzts1 lzts2 mad1l1 mad2l1 mad2l2 mapk1 ma pk12 mapk13 mapk3 mapk4 mapk6 mapk7 mapre1 mapre2 mapre3 mcc

33、mcm2 m cm3 mcm6 mcm7 mcm8 mdc1 mis12 mki67 mlh1 mn1 mnat1 msh2 mtss1 mutyh nat6 nbl1 nedd9 nek1 nek11 nek2 nek3 nek4 nek9 nf1 nf2 nipbl nme1 nme2 nolc1 nudc pafah1b1 papd5 parc pard3 pard6a pard6b pard6g pcaf pcnp pcoln3 pfdn1 pin1 pinx1 pkmyt1 pms1 pms2 pnn pols ppm1d ppp1ca ppp1cb ppp1cc ptch pten

34、 ptp4a1 pttg1 pycard rad17 rad21 rad50 rap1a rassf1 rb1cc1 rbbp4 rbl1 rbl2 rbm2 2 rbm5 rcbtb1 rcc1 rcc2 reck rfp2 rgs2 rhob rif1 rint1 rp11-291l22.2 s100a6 sash1 sass6 sept1 sept10 sept11 sept2 sept3 sept4 sept5 sept6 sept7 sept8 sgol1 sgol2 s h3bp4 siah1 siah2 sirt2 smarcb1 smc1l1 smc1l2 smc2l1 smc

35、4l1 smpd3 snf1lk spag5 spin2 sssca1 stag1 stag2 stag3 stim1 strn3 sufu sycp1 sycp2 tacc1 tada2l taf1 taf 1l terf1 terf2 tfdp1 tfdp2 tlk1 tlk2 tp53 tp53bp2 tp73 tsc1 tsc2 tusc2 tusc4 txnl4a t xnl4b uba52 ube1c ube2c uhrf1 uhrf2 usp16 vash1 vhl wee1 wt1 wwox xrn1 zak zc 3hc1 zmynd11 zw10 zwint zwintas

36、细胞周期检控点 (cell cycle checkpoint) 11: atr brca1 ccne2 ccng2 cdkn2a fancg rad1 rb1 smc1l1 tp53 zak 细胞周期停滞 (cell cycle arrest) 68: aif1 apbb1 apbb2 bard1 btg4 c10orf7 cdkn1a cdkn1b cdkn 1c cdkn2a cdkn2b cdkn2c cdkn2d cdkn3 cgref1 cgrrf1 cul1 cul2 cul3 cul4a cul5 ddi t3 dhcr24 dst eif4g2 ern1 gadd45a gas

37、1 gas2 gas2l1 gas2l2 gas2l3 gas7 hbp1 ifnw 1 il8 ing4 inha inhba jmy khdrbs1 macf1 map2k6 mapk12 mfn2 mllt7 mphosph1 myc nbn notch2 pa2g4 pcaf pcbp4 plagl1 pml ppm1g ppp1r15a ppp2r3b rassf1 sa rt1 sesn1 sesn2 sesn3 tbrg4 tp53 uhmk1 vash1 zak雄性减数分裂 (male meiosis) 3: hspa2 pim2 taf1l雄性减数分裂 I (male mei

38、osis I) 1: ccna1一维细胞生长 (unidimensional cell growth) 1: bin3引导细胞凋亡 (induction of apoptosis) 92: alox15b apoe bad bak1 bax bcl10 bcl2l11 bcl2l13 b claf1 bik bnip3 bnip3l bok casp10 casp3 casp4 casp6 cd2 cias1 cideb cidec col4a3 dapk2 dapk3 dcc dedd diablo dpf1 ei24 ercc2 ercc3 ern1 ern2 fas faslg foxo

39、3a hd hrk ifna2 ifnb1 ikbkg inha inhba jmy lalba lck lta mal map3k10 mapk1 mx1 nalp1 n me3 notch2 nudt2 p8 pdcd5 plagl1 plg pml ppp1r13b ppp2ca ppp2r1a ppp2r1b p rkce pten pycard s100b sipa1 smndc1 stk17a stk17b tia1 tial1 tlr2 tnfrsf10a tnfrsf1 9 tnfrsf7 tnfrsf9 tnfsf10 tnfsf12 tnfsf14 tnfsf8 tp53b

40、p2 tp73l tpd52l1 tradd traf3 tra ip unc13b utp11l znf443引导细胞凋亡经死亡域受体 (induction of apoptosis via death dom-ain receptors) 10: bid cradd daxx dedd d edd2 diablo fadd il18 tnfrsf10a tnfrsf10b引导细胞凋亡由胞外信号 (induction of apoptosis by extracellular signals) 19: adora1 bax btk casp8ap2 cd38 cflar dap dap3 d

41、apk1 dpf2 fastk map3k5 ndufa13 pdcd6 prkca ripk3 siva timp3 tnfrsf25引导细胞凋亡由激素 (induction of apoptosis by hormones) 3: pth sstr3 tp53 引导细胞凋亡由细胞内信号 (induction of apoptosis by intracellular signals) 9: cdkn1a cul1 cul2 cul3 cul4a c ul5 hipk2 lgals12 sart1引导细胞凋亡由氧化压力 (induction of apoptosis by oxidative

42、 stress) 2: prodh rnf7 有丝分裂 (mitosis) 98: akap8 anapc1 anapc11 anapc2 anapc7 aspm aurka brrn1 bub1 bub1b bub3 ccdc16 ccdc5 ccna1 ccna2 ccnb1 ccnb2 ccnf ccng1 ccng2 ccnk cdc2 cdc2 0 cdc25a cdc25b cdc2l1 cdc2l2 cdc6 cdca5 cdk2 cdk3 cenpf cetn1 cetn2 cetn3 chfr cit clasp1 clasp2 cnap1 coro1a dclre1a dc

43、tn1 dctn2 dctn3 eml4 fgf4 flj37927 fzr1 hcap-g hgf incenp katna1 katnb1 kif22 kif23 kif2c kntc1 lats1 lats2 mad2l1 mad2l2 mapre1 mapre2 mapre3 mis12 nedd9 nek1 nek3 nek4 nek9 nolc1 nudc pafah1b1 papd5 pbk plk1 pols ppp5c pttg1 rad21 rcc2 sgol1 sirt2 smc2l1 spag5 sssca1 stag 1 stag2 sugt1 tardbp tpx2 ttn txnl4a tx