一项随机对照试验：结合吸气肌的肌肉整体训练在儿童囊性纤维化的好处

1、_项随机对照试验:结合吸气肌的肌肉整体训练在儿童囊性纤维化的好处Br J Sports Med doi:10. 1136/bjsportsxx091892Original article Benefits of bining inspiratory muscle with 'whole muscletraining in children with cystic fibrosis: a randomised controlled trial 一项随机对照试验： 结合吸气肌的肌肉整体训练在儿童囊性纤维化的好处1 Elena Santana-Sosal, 2 Laura Gonzalez-

2、Saizl, 3 Iris F Groeneveld2, 4 JosO R Villa-Asensi3, 5 Maria I Barrio G6mez de Aguero3, 6 Steven J Fleck4, 7 Luis M LdpezMojaresl, 8 Margarita Prezl, 9 Alejandro Lucial, 5 +AuthorAffiliationslSchool of Doctorate Studies and Research, Universidad Europea de Madrid, Spain2Academic Medical Center, Univ

3、ersity of Amsterdam, Amsterdam, The herlands3Department of Pneumology, Hospital "Nino Jesus' of Madrid, Madrid, Spain4Department of Hea1th, Exercise Science and Sport Management, University of Wisconsin-Parkside, Kenosha, Wisconsin, USASInstituto de Investigacidn i+12, Madrid, SpainlO Corre

4、spondence toDr Alejandro Lucia, Universidad Europea de Madrid,Villaviciosa de 0d6n, Madrid28670,Spain;alejandro. 1uciauem. es Acceptedl Januaryxx Published Online Firstl6 Mayxx Abstract Background The purpose of this study (randomised controlled trial)was to assess the effects of an8-week bined '

5、;whole muscle' (resistance+aerobic)and inspiratory muscle training (IMT)on lung volume, inspiratory muscle strength (Plmax) and cardiorespiratory fitness (V02 peak)(primary outes), and dynamic muscle strength, body position and quality of life in paediatrie outpatients with CF (evstic fibrosis,

6、secondary outes). We also determined the effects of a detraining period Methods Participants were randomly allocated with a block on gender to a control (standard therapy)or intervention group (initial n二10 (6 boys)in each group; agel0± 1 andll± 1 years) The latter group performed a bined

7、programme (IMT (2 sessions/day)and aerobic+strength exercises (3 days/week, in- hospital)that was followed by a4week detraining period Allparticipants were evaluated at baseline, post-training and detraining Results Adherence to the training programme averaged97. 5%±1. 7%. There was a significa

8、nt interaction(group X time)effect for Plmax,V02peak and five-repetition maximum strength (leg-press, bench-press, seated-row)(all (p<0.001), and also for %fat (p<0.023)and %fat-free mass (p二0.001), with training exerting a significant beneficial effect only in the intervention group, which was maintained after detraining for Plmax and leg-press. Conclusion The relativelv short-term (8 week)training programme used here induced significant benefits in important hea1th phenotypes of paediatrie patients with CF IMT is an