合成宏观循环的高光组织化学研究

1、第二十届全国金属有机化学学术讨论会南京2018年口月high valent organocopper chemistry probed withsynthetic macrocycles*meixicmg必昭(王梅祥)moe key laboratory of bioorganic phosphorous chemistry and chemical biology,department of chemishy, tsinghua university, beijing 100084, chinae-mail: wcingmxmailtsinghuacoppcr-catalyzcd and m

2、ediated cross coupling reactions arc one of the most frequently used methods in the synthesis of carbon-carbon and carbon-heteroatom bonds recently, copper catalysis has also been shown to be a promising strategy in c-h bond activation and functionalization. despite the wide applications of copper s

3、alts in catalysis, reaction mechanisms have remained elusive owing to the difficulty in identifying the structure and reactivity of organocopper species involved in organometallic reactions using hctcracalixaromatics (1), a type of synthetic macrocycles in which the multiple and convergent coordinat

4、ion sites are readily designed, we have synthesized selectively an array of structurally well-defined high valent arylcopper(ii) (2) and arylcopper(iii) compounds (3). synthetic macrocycles and their organocopper complexes of different oxidation states provide us with unique and powerful molecular t

5、ools to probe the mechanism of copper catalysis i will present in this symposium the recent advance of our study on organometallic chemistry of high valent organocopper(ii) and (iii) compounds with the emphasis on arene c-h activation and cross-couplingreaction with anionic nucleophiles, boronic aci

6、ds and radicals.x, y, z, w = heteroatomsa, b. c. d (hetero)aromatics2figure 1.3references： 1 m.-x. wang* acc. chem. res. 2012, 45. 182-195. b. yao, d,-x. wang, z.t. huang and m.-x. wang* chem. commim. 2009, 2899-2901. h. zhang, b. yao, l. zhao, d.-x. wang, b.-q. xu and m.-x. wang1 j. am. chem. soc.

7、2014, 136, 6326-6332.4 q. zhang, y. liu, t. wang, x. zhang,* c. long, y：d wu and m.-x. wang* j. am. chem. soc. 2018,140, 5579-5587.5 q. zhang, t. wang, x. zhang,* y.-d. wu and m.-x. wang* manuscript in preparation.the nsfc (21572111 and 21732004) for financial support.第二十届全国金属有机化学学术讨论会南京2018年口月mei-x

8、iang wang ( flprofessor of chemistrydepartment of chemistry, tsinghua university, beijing 100084, chinatel:+86-10-62797527e-mail: wangmx09. 1979-07. 1983undergraduate student at fudan university08. 1983-08. 1986research associate at grinfm09. 1986-03. 1992phd student at iccas (supervisor, zhi-tang h

9、uang)04. 1992-12. 1993research associate at iccas07. 1994-06. 1997postdoctoral fellow at sunderland university (supervisor, ottomcth-cohn)01. 1994-07. 1997research associate professor at iccas08. 1997-05.2009research professor at iccas05.2009-prcscntprofessor at tsinghua universityresearch interests

10、macrocyclic and supramolecular chemistry, anion-pi non-covalent bond interactions, high valent organocopper chemistry, enantioselective chemical transformations and biotransformationsawardschinese chemical society golden award for creativity in synthetic chemistry (2005) chinese chemical society awa

11、rd for physical organic chemistry (2017)representative publications1. m.-x. wang,* acc. chem. res. 2012, 45, 182-195.2. m.-x. wang,* chem. conumin. 2015, 57, 6039-6049.3. m.-x. wang,* acc. chem. res. 2015, 48, 602-611.4. m.-x. wang,* sci. china chem. 2018, 61, 993-1003.5. h.-b. liu, q. zhang, m.-x.

12、wang,* angew. chem. int. ed. 201 & 57, 6536-6540.6. q. zhang, y. liu, t. wang, x. zhang,* c. long, y.-d. wu, m.-x. wang,* j. am. chem. soc. 2018,140, 5579-5587.7. z.-c wu, q.-h, guo, m.-x. wang,* angew. chem. int. ed. 2017, 56, 7151-7155.8. x.-m. xu, l. zhao, j. zhu, m.-x. wang,* angew. chem. int. ed. 2016, 55, 3799-3803.9. q.-ii. guo, z.-d. fu, l. zhao, m.-x. wang,* angew. chem. int. ed. 2015, 54, 8386-8389.10.