替吉奥不同用药方案及有效率汇总

1、替吉奥（S-1）不同用药方案及有效率汇总表1替吉奥胶囊（S-1）用于胃癌用药方案及有效率用药方案用法用量RRMST参考文献S-1S-1:40mg/m2,bid4W,q6w44.6%244dMaeharaY,GastricCancer.2003;6S-1+顺柏S-1:40-60mg/m2,bid3W,q5w顺钳：60mg/m2,iv,D854%13.0mKoizumiW,ASCO,2008S-1+多西他赛S-1:40mg/m2,bid2W,q3w多西他赛：40mg/m2,iv,D156.3%14.3mKazuhiroYoshida,ClinCancer,Res2006;12(11):3402S-

2、1+顺柏+多西他赛S-1:40mg/m2,bid2w,q2w顺钳:60mg/m2,iv,D1多西他赛:40mg/m2,iv,D182.5%N.Nakayama,etal.ASCO,2009S-1+伊立替康S-1:40-60mg/m2,bid3w伊立普康:80mg/m,iv,D1、1547.8%394dNoriyaUedo,etal.Oncology2007;73:65-71S-1+奥沙利伯S-1:40mg/m2,bid2w,q3w奥沙利钳:100mg/m2,iv,D158.8%HTakiuchi,etal.ASCO,2009S-1+伊立替康+奥沙利伯S-1:40mg/m2,bid2w,q3w伊

3、立替康:150mg/m,iv,D1奥沙利钳:85mg/m2,iv,D174.3%S.R.Park,ASCO,2008S-1+紫杉醇S-1:40mg/m2,bid2w,q3w紫杉醇ip,20mg/m2,iv,50mg/m2,D1、862%J.Kitayama,ASCO,2009表2替吉奥胶囊（S-1）用于结肠直肠癌用药方案及有效率用药方案用法用量RRmPFS,经受文献S-1S-1:40-60mg/m2,bid4w,q6w35.5%OhtsuA,BrJCancer83:141-145S-1+伊立替康S-1:40-60mg/m2,bid2w,q3w伊立普康：150mg/m,D162.5%8.0mGo

4、toA.,AnnOncol,2006(17):968S-1+奥沙利伯S-1:40-60mg/m2,bid2w,q3w奥沙利钳：100-130mg/m2,D150%196dBritishJournalofcancer,2008,98,1034-1038表3替吉奥（S-1）用于胰腺癌用药方案及有效率用药方案用法用量RRMST参考文献S-1S-1:40-60mg/m2,bid4w,q6w37.5%9.2mCancerChemotherPharmacol.2008,61:615621S-1+吉西他滨S-1:30-40mg/m2,bid2w吉西他滨:800-1000mg/m2,D8、1548%12.5m

5、BritishJournalofCancer.2007,96:1353-1357S-1+放疗S-1:30-40mg/m2,放疗36%12.3mBritishJournalofCancer.2005,92:2134-2139表4替吉奥（S-1）用于非小细胞肺癌（NSCLC的临床研究用药方案及有效率用药方案用法用量RRmOS参考文献S-1S-1:40mg/m2,bid4W,q6w22.0%10.2mBritishJournalofCancer,2001,85:939S-1+顺柏S-1:40mg/m2,bid3W,q5w顺钳：60mg/m2/d,D847.0%11mClinicalcanerrese

6、arch,2004,12:7860S-1:40mg/m2,bid3W,q5w顺钳：25mg/m2/d,D7、14、2123.1%13.4mLungCancer,2009,63:68S-1+顺柏+胸腔放疗S-1:30-40mg/m2,bid2w,q4w顺钳：30-50mg/m2/d,D1、8;胸腔放疗86.4%24.4mLungCancer,65(2009):7429S-1:40mg/m2,bid2w,q4w顺钳：60mg/m2/d,D1胸腔放疗87.5%33.1mOhyanagiF,etal.BrJCancer.2009,101(2):225-31S-1+伊立替康S-1:40mg/m2,bid

7、2w,q3w伊立普康：150mg/m/d,D128.6%15mOkamotoI,etal.ClinCancerRes.2008,14(16):5250S-1十多西他赛(已化疗过的NSCLC患者)S-1:40mg/m2,bid2w,q3w多西他赛：40mg/m2,D124.1%11.8mAtagiS,etal.JThoracOncol.2008,3(9):1012-7表5替吉奥胶囊（S-1）用于乳腺癌用药方案及有效率用药方案用法用量RRMST参考文献S-1S-1:40mg/m2,bid4w,q6w41.7%872dBreastCancer,2004,11(2):194S-1:40-60mg/m2

8、/d,bid4w,q6w42%910dSaekiT,etal.GanToKagakuRyoho.2004,31(4):539-47表6替吉奥（S-1）用于头颈部癌用药方案及有效率用药方案RR参考文献S-128.8%InuyamaY,Cancer&chemotherapy,2001;28(10):1381S-1+顺柏67.6%FujiiM.GanToKagakuRyoho.2006,33Suppl1:150S-1+卡柏40.9%AkihitoWatanabe,WileyInterScience,2006:620-625表7替吉奥（S-1）用于转移性或复发性胆管癌用药方案及有效率用药方案用

9、法用量RRmOS参考文献S-1S-1:40mg/m2,bid4w,q6w21.1%8.3mUenoH,OkusakaT,etal.BrJCancer.2004Nov15;91(10):1769-74S-1+顺柏S-1:40mg/m2,bid2w,q3w顺钳：60mg/m2,iv,D130%8.7mKimYJ,ImSA,etal.AnnOncol.2008Jan;19(1):99-103.Epub2007Sep9S-1+吉西他滨S-1:40mg/m2,bid2w吉西他滨：1000mg/m2,D1,D15,q4w34.3%11.6mTakashiSasaki,HiroyukiIsayamaetal.CancerChemotherapyandPharmacology,2009说明：以上图表中，S-1指替吉奥胶囊；RR指有效率；MST指中位生存时间；244d指244天；13.0m指13.0个月；40mg/m指根据患者体表面积用药，替吉奥一次用量40mg每平方米；bidX2w指一天两次用药（bid）,连续用药2周；q