重组人肝细胞生长因子 (CHO 细胞表达)作用机制 - Medchemexpress - MCE中国

1、Product Data SheetRecombinant Human Hepatocyte Growth Factor (CHO-expressed)Cat. No.: HY-P7121Synonyms: rHuHGF; Hepatopoietin-A; SFSpecies: HumanSource: CHOAccession: P14210Gene ID: 3082Molecular Weight: 88-90 kDaPROPERTIESAA SequenceQ R K R R N T I H E F K K S A K T T L I K I D P A L K I K T K K V

2、N T A D Q C A N R C T R N K G L P F T C K A F V F D K A R K Q C L W F P F N S M S S G V K K E F G H E F D L Y E N K D Y I R N C I I G K G R S Y K G T V S I T K S G I K C Q P S N P E V R Y E V C D I P Q C S E V E C M T C N G E S Y R G L MD H T E S G K I C Q R WD H Q T P H R H K F L P E R Y P D K G F

3、D D N Y C R N P D G Q P R P W C Y T L D P H T R W E Y C A I K T C A D N T MN D T D V P L E T T E C I Q G Q G E G Y R G T V N T I W N G I P C Q R WD S Q Y P H E H DM T P E N F K C K D L R EN Y C R N P D G S E S P W C F T T D P N I R V G Y C S Q I P N C DM S H G Q D CD T T P T I V N L D H P V I S C A

4、K T K Q L R V V N G I P T R T N I GWM V S LD F V S T I D L P N Y G C T I P E K T S C S V Y GWG Y T G L I N Y D G L L R VD Y G G P L V C E Q H K M R M V L G V I V P G R G C A I P N R P G I F V R V A Y Y A K W I H K I I L T Y K V P Q SW S S M I P H E H S F L P S S Y R G K D L Q E N Y C R N P R G E E G

5、 G P W C F T Y R G N G K N Y MG N L S Q T R S G L T C S MWD K NM E D L H R H I F W E P DA S K L N E N Y C R N P D D D A H G P W C Y T G N P L I P W D Y C P I S R C E G R Y R N K H I C G G S L I K E S W V L T A R Q C F P S R D L K D Y E AW L G I HD V H G R G D E K C K Q V L N V S Q L V Y G P E G S D

6、L V L M K L A R P A V L DA H L Y I MG N E K C S Q H H R G K V T L N E S E I C A G A E K I G S G P C E GBiological Activity The ED50 is 1 105 units/mg.Appearance Lyophilized powder.Formulation Lyophilized after extensive dialysis against PBS.Endotoxin Level 0.2 EU/g, determined by LAL method.Reconsit

7、itution Reconstitute the lyophilized recombinant Human Hepatocyte Growth Factor (CHO-expressed) (rHuHGF) to 100g/mL using ddH2O or diluted with PBS.Storage & StabilityLyophilized recombinant Human Hepatocyte Growth Factor (CHO-expressed) (rHuHGF) is stored at -20C. AfterPage 1 of 2 www.MedChemErecon

8、stitution, it is stable at 4C for 1 weeks or -20C for longer. It is recommended to freeze aliquots at -20C or -80C for extended storage.Shipping Room temperature in continental US; may vary elsewhere.DESCRIPTIONBackground Hepatocyte growth factor (HGF) exhibits biological activities through the Met

9、tyrosine kinase receptor. HGF plays arole in the regeneration and protection from injury and pathology in various tissues. Genetic disruption of Met inrenal cells demonstrates that the HGF-Met pathway plays a role in the proliferation, morphogenesis, and survival ofrenal cells1.REFERENCES1. Adachi E, et al. Pharmacokinetics and pharmacodynamics following intravenous administration of recombinant human hepatocyte growth factor in ratswith renal injury. Pharmacology. 2014;94(3-4):190-7.McePdfHeightCaution: Product has not been fully validated for medical applica