Mevastatin-Compactin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMevastatinCat. No.: HY-17408CAS No.: 73573-88-3Synonyms: Compactin; ML236B分式: CHO分量: 390.51作靶点: HMG-CoA Reductase (HMGCR); Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mon

2、ths-20C 1 month溶解性数据体外实验 DMSO : 25 mg/mL (64.02 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5608 mL 12.8038 mL 25.6075 mL5 mM 0.5122 mL 2.5608 mL 5.1215 mL10 mM 0.2561 mL 1.2804 mL 2.5608 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储

3、备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.40 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.40 mM); Clear solution3. 请依序添加每种溶

4、剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.40 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Mevastatin (Compactin; ML236B)抑制HMG-CoA还原酶（HMGCR），可抑制类异戊烯的物合成，阻断蛋的异戊烯化，降低浆胆 醇平。户使本产品发表的科研献 Eur Res J. March 20, 2018.See more customer validations on HYPERLI

5、NK / www.MedChemEREFERENCES1. Sugazaki M, Hirotani H, Echigo S, et al. Effects of mevastatin on grafted bone in MRL/MpJ mice. Connect Tissue Res. 2010Apr;51(2):105-12. doi: 10.3109/03008200903105098.2. Evangelopoulos ME, Weis J, Krttgen A. Mevastatin-induced neurite outgrowth of neuroblastoma cells

6、via activation of EGFR. JNeurosci Res. 2009 Jul;87(9):2138-44. doi: 10.1002/jnr.22025.3. W?chtersh?user A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in thecolorectal carcinoma cell line Caco-2. Carcinogenesis. 2001 Jul;22(7):1061-7.4.

7、 Amin-Hanjani S, Stagliano NE, Yamada M, et al. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulatesendothelial nitric oxide synthase in mice. Stroke. 2001 Apr;32(4):980-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use on